FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005807722> ?p ?o ?g. }

• W2005807722 endingPage "79" @default.
• W2005807722 startingPage "71" @default.
• W2005807722 abstract "Ginsenoside metabolite compound K (CK; 20-<i>O</i>-d-glucopyranosyl-20(<i>S</i>)-protopanaxadiol), a novel ginsenoside metabolite, belongs to the dammarane-type triterpene saponins, according to its structure. The anti-inflammatory activity of CK has been identified in several studies. Our study demonstrated that CK exerted an anti-inflammatory effect in collagen-induced arthritis (CIA) and adjuvant-induced arthritis animal models, and this effect was due to inhibition of the abnormal activation and differentiation of T cells. However, the mechanism of CK in suppressing T-cell activation remains unclear. In this study, CK had a therapeutic effect in mice with CIA, decreased the percentage of activated T cells and dendritic cells (DCs), and increased the percentage of naive T cells in lymph nodes. The inhibitory effect on T-cell activation of CK was related to suppression of accumulation of DCs in lymph nodes. CK decreased CCL21 levels in lymph nodes and CCR7 expression in DCs and suppressed CCL21/CCR7-mediated migration of DCs, thus reducing accumulation of DCs in lymph nodes. In addition, signals for T-cell activation including major histocompatibility complex class II and costimulatory molecules, such as CD80 and CD86, were suppressed by CK, and the proliferation of T cells induced by DCs was inhibited by CK. In conclusion, this study demonstrated that CK downregulated DC priming of T-cell activation in CIA, and suppression of CCL21/CCR7-mediated DC migration and signaling between T cells and DCs might be the potential mechanism. These results provide an interesting, novel insight into the potential mechanism by which CK contributes to the anti-inflammatory effect in autoimmune conditions." @default.
• W2005807722 created "2016-06-24" @default.
• W2005807722 creator A5003799076 @default.
• W2005807722 creator A5006596488 @default.
• W2005807722 creator A5010856020 @default.
• W2005807722 creator A5013419645 @default.
• W2005807722 creator A5046880683 @default.
• W2005807722 creator A5072802017 @default.
• W2005807722 date "2015-01-28" @default.
• W2005807722 modified "2023-09-30" @default.
• W2005807722 title "Ginsenoside Metabolite Compound K Suppresses T-Cell Priming via Modulation of Dendritic Cell Trafficking and Costimulatory Signals, Resulting in Alleviation of Collagen-Induced Arthritis" @default.
• W2005807722 cites W1942291252 @default.
• W2005807722 cites W1972988154 @default.
• W2005807722 cites W1973722969 @default.
• W2005807722 cites W1982324049 @default.
• W2005807722 cites W1983000591 @default.
• W2005807722 cites W1986421860 @default.
• W2005807722 cites W1998481877 @default.
• W2005807722 cites W1998647423 @default.
• W2005807722 cites W2006123588 @default.
• W2005807722 cites W2007286155 @default.
• W2005807722 cites W2007511032 @default.
• W2005807722 cites W2011849870 @default.
• W2005807722 cites W2018932486 @default.
• W2005807722 cites W2019881908 @default.
• W2005807722 cites W2022131506 @default.
• W2005807722 cites W2024465345 @default.
• W2005807722 cites W2033986959 @default.
• W2005807722 cites W2036517776 @default.
• W2005807722 cites W2039730257 @default.
• W2005807722 cites W2040977790 @default.
• W2005807722 cites W2041587341 @default.
• W2005807722 cites W2043683714 @default.
• W2005807722 cites W2045046224 @default.
• W2005807722 cites W2048939676 @default.
• W2005807722 cites W2054407742 @default.
• W2005807722 cites W2057024357 @default.
• W2005807722 cites W2058726769 @default.
• W2005807722 cites W2062913054 @default.
• W2005807722 cites W2065029485 @default.
• W2005807722 cites W2074598924 @default.
• W2005807722 cites W2076021677 @default.
• W2005807722 cites W2080026792 @default.
• W2005807722 cites W2080712292 @default.
• W2005807722 cites W2087054392 @default.
• W2005807722 cites W2089162433 @default.
• W2005807722 cites W2101508686 @default.
• W2005807722 cites W2110413597 @default.
• W2005807722 cites W2110553629 @default.
• W2005807722 cites W2123728295 @default.
• W2005807722 cites W2148371571 @default.
• W2005807722 cites W2151601140 @default.
• W2005807722 cites W2165020893 @default.
• W2005807722 cites W2326490741 @default.
• W2005807722 cites W2330830480 @default.
• W2005807722 cites W62994122 @default.
• W2005807722 doi "https://doi.org/10.1124/jpet.114.220665" @default.
• W2005807722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25630466" @default.
• W2005807722 hasPublicationYear "2015" @default.
• W2005807722 type Work @default.
• W2005807722 sameAs 2005807722 @default.
• W2005807722 citedByCount "37" @default.
• W2005807722 countsByYear W20058077222015 @default.
• W2005807722 countsByYear W20058077222016 @default.
• W2005807722 countsByYear W20058077222018 @default.
• W2005807722 countsByYear W20058077222019 @default.
• W2005807722 countsByYear W20058077222020 @default.
• W2005807722 countsByYear W20058077222021 @default.
• W2005807722 countsByYear W20058077222022 @default.
• W2005807722 countsByYear W20058077222023 @default.
• W2005807722 crossrefType "journal-article" @default.
• W2005807722 hasAuthorship W2005807722A5003799076 @default.
• W2005807722 hasAuthorship W2005807722A5006596488 @default.
• W2005807722 hasAuthorship W2005807722A5010856020 @default.
• W2005807722 hasAuthorship W2005807722A5013419645 @default.
• W2005807722 hasAuthorship W2005807722A5046880683 @default.
• W2005807722 hasAuthorship W2005807722A5072802017 @default.
• W2005807722 hasBestOaLocation W20058077221 @default.
• W2005807722 hasConcept C100701293 @default.
• W2005807722 hasConcept C127801297 @default.
• W2005807722 hasConcept C12823836 @default.
• W2005807722 hasConcept C13373296 @default.
• W2005807722 hasConcept C154317977 @default.
• W2005807722 hasConcept C185592680 @default.
• W2005807722 hasConcept C202751555 @default.
• W2005807722 hasConcept C203014093 @default.
• W2005807722 hasConcept C2776090121 @default.
• W2005807722 hasConcept C2776914184 @default.
• W2005807722 hasConcept C2777077863 @default.
• W2005807722 hasConcept C2778170410 @default.
• W2005807722 hasConcept C2778297628 @default.
• W2005807722 hasConcept C2781101188 @default.
• W2005807722 hasConcept C39347974 @default.
• W2005807722 hasConcept C55493867 @default.
• W2005807722 hasConcept C59822182 @default.
• W2005807722 hasConcept C81444415 @default.
• W2005807722 hasConcept C86803240 @default.
• W2005807722 hasConcept C8891405 @default.

• next