Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005808540> ?p ?o ?g. }
- W2005808540 endingPage "1057" @default.
- W2005808540 startingPage "1047" @default.
- W2005808540 abstract "Matrix metalloproteinase-2 (MMP-2) is a key regulator in wound healing that orchestrates tissue remodeling. In the present study the spatial and temporal distribution of MMP-2 gene transcription, protein synthesis, and enzymatic activity were analyzed following polymeric mesh (polyglactin, polypropylene) implantation in transgenic reporter mice harboring MMP-2 regulatory sequences -1686/+423 or -1241/+423. Polymers induced MMP-2 promoter activity in macrophages within the foreign body granuloma via sequences -1686/+423 with concomitantly up-regulated protein synthesis and enzymatic activity. Macrophages distant from mesh filaments exhibited low MMP-2 expression levels. Fibroblasts surrounding mesh material displayed strong MMP-2 gene transcription independent of the included promoter sequences, whereas fibroblasts without close contact to mesh material had low MMP-2 synthesis rates due to silencing activity of sequences -1686/-1241. In vitro studies support a cellular crosstalk concept, as macrophages trans-repressed MMP-2 gene transcription in fibroblasts. The zonal and cell-specific regulation of MMP-2 gene transcription illuminates an intimate cellular crosstalk in foreign body reaction that may provide a new approach for mesh modification." @default.
- W2005808540 created "2016-06-24" @default.
- W2005808540 creator A5016687099 @default.
- W2005808540 creator A5026344930 @default.
- W2005808540 creator A5043052973 @default.
- W2005808540 creator A5044042697 @default.
- W2005808540 creator A5050024715 @default.
- W2005808540 creator A5058204085 @default.
- W2005808540 creator A5061315678 @default.
- W2005808540 creator A5072405170 @default.
- W2005808540 creator A5085791653 @default.
- W2005808540 creator A5071940311 @default.
- W2005808540 date "2007-01-10" @default.
- W2005808540 modified "2023-10-14" @default.
- W2005808540 title "Polymeric meshes induce zonal regulation of matrix metalloproteinase‐2 gene expression by macrophages and fibroblasts" @default.
- W2005808540 cites W1488829562 @default.
- W2005808540 cites W1525484196 @default.
- W2005808540 cites W1555610421 @default.
- W2005808540 cites W1600831053 @default.
- W2005808540 cites W166240207 @default.
- W2005808540 cites W1759279244 @default.
- W2005808540 cites W1846208898 @default.
- W2005808540 cites W1890561088 @default.
- W2005808540 cites W1968776283 @default.
- W2005808540 cites W1969375564 @default.
- W2005808540 cites W1975427965 @default.
- W2005808540 cites W1989331022 @default.
- W2005808540 cites W1998029054 @default.
- W2005808540 cites W2003782243 @default.
- W2005808540 cites W2005328558 @default.
- W2005808540 cites W2007849798 @default.
- W2005808540 cites W2013797466 @default.
- W2005808540 cites W2018725775 @default.
- W2005808540 cites W2025571426 @default.
- W2005808540 cites W2027636739 @default.
- W2005808540 cites W2027638853 @default.
- W2005808540 cites W2030281917 @default.
- W2005808540 cites W2031730932 @default.
- W2005808540 cites W2033341544 @default.
- W2005808540 cites W2034226927 @default.
- W2005808540 cites W2046821312 @default.
- W2005808540 cites W2048172586 @default.
- W2005808540 cites W2050737726 @default.
- W2005808540 cites W2052660171 @default.
- W2005808540 cites W2056501914 @default.
- W2005808540 cites W2057448298 @default.
- W2005808540 cites W2059919196 @default.
- W2005808540 cites W2061025835 @default.
- W2005808540 cites W2066783138 @default.
- W2005808540 cites W2085077495 @default.
- W2005808540 cites W2088050057 @default.
- W2005808540 cites W2088497174 @default.
- W2005808540 cites W2092377409 @default.
- W2005808540 cites W2092388342 @default.
- W2005808540 cites W2104790898 @default.
- W2005808540 cites W2114315030 @default.
- W2005808540 cites W2117360090 @default.
- W2005808540 cites W2120657790 @default.
- W2005808540 cites W2136115649 @default.
- W2005808540 cites W2146232095 @default.
- W2005808540 cites W2152487395 @default.
- W2005808540 cites W2344929644 @default.
- W2005808540 cites W4241912353 @default.
- W2005808540 doi "https://doi.org/10.1096/fj.06-6755com" @default.
- W2005808540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17215487" @default.
- W2005808540 hasPublicationYear "2007" @default.
- W2005808540 type Work @default.
- W2005808540 sameAs 2005808540 @default.
- W2005808540 citedByCount "25" @default.
- W2005808540 countsByYear W20058085402012 @default.
- W2005808540 countsByYear W20058085402013 @default.
- W2005808540 countsByYear W20058085402014 @default.
- W2005808540 countsByYear W20058085402015 @default.
- W2005808540 countsByYear W20058085402016 @default.
- W2005808540 countsByYear W20058085402018 @default.
- W2005808540 countsByYear W20058085402020 @default.
- W2005808540 countsByYear W20058085402021 @default.
- W2005808540 crossrefType "journal-article" @default.
- W2005808540 hasAuthorship W2005808540A5016687099 @default.
- W2005808540 hasAuthorship W2005808540A5026344930 @default.
- W2005808540 hasAuthorship W2005808540A5043052973 @default.
- W2005808540 hasAuthorship W2005808540A5044042697 @default.
- W2005808540 hasAuthorship W2005808540A5050024715 @default.
- W2005808540 hasAuthorship W2005808540A5058204085 @default.
- W2005808540 hasAuthorship W2005808540A5061315678 @default.
- W2005808540 hasAuthorship W2005808540A5071940311 @default.
- W2005808540 hasAuthorship W2005808540A5072405170 @default.
- W2005808540 hasAuthorship W2005808540A5085791653 @default.
- W2005808540 hasConcept C101762097 @default.
- W2005808540 hasConcept C102230213 @default.
- W2005808540 hasConcept C104317684 @default.
- W2005808540 hasConcept C109523444 @default.
- W2005808540 hasConcept C119056186 @default.
- W2005808540 hasConcept C120665830 @default.
- W2005808540 hasConcept C121332964 @default.
- W2005808540 hasConcept C138885662 @default.
- W2005808540 hasConcept C150194340 @default.
- W2005808540 hasConcept C153911025 @default.