Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005808552> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2005808552 endingPage "240" @default.
- W2005808552 startingPage "233" @default.
- W2005808552 abstract "N-Nitroso-2-methoxy-2,6-dimethylmorpholine (MeNDMM), a cyclic derivative of the proposed proximate pancreatic carcinogen N-nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP), is shown to have an almost selective cytotoxic effect on pancreatic β-cells when a single high dose is given to Syrian hamsters. Hence in this aspect its effect is comparable to that of streptozotocin, which has a glucose moiety similar to the MeNDMM structure. However, contrary to the effect of streptozotocin, low single (subdiabetogenic) doses of MeNDMM led to the development of pancreatic ductular and mixed ductular-insular neoplasms; only 1 animal also had islet cell adenoma. It therefore seems that MeNDMM possesses an affinity for both endocrine and exocrine pancreatic tissue. Other target tissues of MeNDMM were the forestomach, intra- and extrahepatic bile ducts, liver, kidneys and vagina. The tumors of these organs appeared in various incidences, partially in relation to dose and/or survival time. The possible mechanisms of the MeNDMM effect upon the endocrine and the exocrine pancreas is discussed." @default.
- W2005808552 created "2016-06-24" @default.
- W2005808552 creator A5002872975 @default.
- W2005808552 creator A5010130303 @default.
- W2005808552 creator A5042025121 @default.
- W2005808552 date "1981-08-01" @default.
- W2005808552 modified "2023-09-26" @default.
- W2005808552 title "The effect of N-nitroso-2-methoxy-2,6-dimethylmorpholine on endocrine and exocrine pancreas of Syrian hamsters" @default.
- W2005808552 cites W1594882065 @default.
- W2005808552 cites W1928216482 @default.
- W2005808552 cites W2000310424 @default.
- W2005808552 cites W2039569538 @default.
- W2005808552 cites W2044222811 @default.
- W2005808552 cites W2061480738 @default.
- W2005808552 cites W2083448941 @default.
- W2005808552 cites W2134022813 @default.
- W2005808552 cites W2335757080 @default.
- W2005808552 cites W2337048003 @default.
- W2005808552 cites W2406893693 @default.
- W2005808552 doi "https://doi.org/10.1016/0304-3835(81)90023-9" @default.
- W2005808552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6271393" @default.
- W2005808552 hasPublicationYear "1981" @default.
- W2005808552 type Work @default.
- W2005808552 sameAs 2005808552 @default.
- W2005808552 citedByCount "4" @default.
- W2005808552 crossrefType "journal-article" @default.
- W2005808552 hasAuthorship W2005808552A5002872975 @default.
- W2005808552 hasAuthorship W2005808552A5010130303 @default.
- W2005808552 hasAuthorship W2005808552A5042025121 @default.
- W2005808552 hasConcept C114246631 @default.
- W2005808552 hasConcept C126322002 @default.
- W2005808552 hasConcept C134018914 @default.
- W2005808552 hasConcept C185592680 @default.
- W2005808552 hasConcept C2778575167 @default.
- W2005808552 hasConcept C2778764654 @default.
- W2005808552 hasConcept C2779280383 @default.
- W2005808552 hasConcept C46699223 @default.
- W2005808552 hasConcept C55493867 @default.
- W2005808552 hasConcept C555293320 @default.
- W2005808552 hasConcept C71315377 @default.
- W2005808552 hasConcept C71924100 @default.
- W2005808552 hasConcept C86803240 @default.
- W2005808552 hasConceptScore W2005808552C114246631 @default.
- W2005808552 hasConceptScore W2005808552C126322002 @default.
- W2005808552 hasConceptScore W2005808552C134018914 @default.
- W2005808552 hasConceptScore W2005808552C185592680 @default.
- W2005808552 hasConceptScore W2005808552C2778575167 @default.
- W2005808552 hasConceptScore W2005808552C2778764654 @default.
- W2005808552 hasConceptScore W2005808552C2779280383 @default.
- W2005808552 hasConceptScore W2005808552C46699223 @default.
- W2005808552 hasConceptScore W2005808552C55493867 @default.
- W2005808552 hasConceptScore W2005808552C555293320 @default.
- W2005808552 hasConceptScore W2005808552C71315377 @default.
- W2005808552 hasConceptScore W2005808552C71924100 @default.
- W2005808552 hasConceptScore W2005808552C86803240 @default.
- W2005808552 hasIssue "3" @default.
- W2005808552 hasLocation W20058085521 @default.
- W2005808552 hasLocation W20058085522 @default.
- W2005808552 hasOpenAccess W2005808552 @default.
- W2005808552 hasPrimaryLocation W20058085521 @default.
- W2005808552 hasRelatedWork W125622540 @default.
- W2005808552 hasRelatedWork W1947645319 @default.
- W2005808552 hasRelatedWork W1982624223 @default.
- W2005808552 hasRelatedWork W1983765718 @default.
- W2005808552 hasRelatedWork W1995071802 @default.
- W2005808552 hasRelatedWork W2003034820 @default.
- W2005808552 hasRelatedWork W2017797235 @default.
- W2005808552 hasRelatedWork W2080520700 @default.
- W2005808552 hasRelatedWork W2084878141 @default.
- W2005808552 hasRelatedWork W2095127010 @default.
- W2005808552 hasVolume "13" @default.
- W2005808552 isParatext "false" @default.
- W2005808552 isRetracted "false" @default.
- W2005808552 magId "2005808552" @default.
- W2005808552 workType "article" @default.