Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005820711> ?p ?o ?g. }
- W2005820711 endingPage "2077" @default.
- W2005820711 startingPage "2067" @default.
- W2005820711 abstract "Systemic infection with Streptococcus pneumoniae is associated with a vigorous pro-inflammatory response to structurally complex cell wall fragments (PnCW) that are shed during cell growth and antibiotic-induced autolysis. Consistent with previous studies, inflammatory cytokine production induced by PnCW was dependent on TLR2 but independent of NOD2, a cytoplasmic NLR protein. However, in parallel with the pro-inflammatory response, we found that PnCW also induced prodigious secretion of anti-inflammatory IL-10 from macrophages. This response was dependent on TLR2, but also involved NOD2 as absence of NOD2-reduced IL-10 secretion in response to cell wall and translated into diminished downstream effects on IL-10-regulated target gene expression. PnCW-mediated production of IL-10 via TLR2 required RIPK2 a kinase required for NOD2 function, and MyD88 but differed from that known for zymosan in that ERK pathway activation was not detected. As mutations in NOD2 are linked to aberrant immune responses, the temporal and quantitative effects of activation of the TLR2-NOD2-RIPK2 pathway on IL-10 secretion may affect the balance between pro- and anti-inflammatory responses to Gram-positive bacteria." @default.
- W2005820711 created "2016-06-24" @default.
- W2005820711 creator A5019030969 @default.
- W2005820711 creator A5021272565 @default.
- W2005820711 creator A5028744677 @default.
- W2005820711 creator A5036791262 @default.
- W2005820711 creator A5040117830 @default.
- W2005820711 creator A5044929807 @default.
- W2005820711 creator A5056364356 @default.
- W2005820711 creator A5072425924 @default.
- W2005820711 creator A5080149508 @default.
- W2005820711 date "2008-10-01" @default.
- W2005820711 modified "2023-10-18" @default.
- W2005820711 title "The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls" @default.
- W2005820711 cites W1492715436 @default.
- W2005820711 cites W1514224413 @default.
- W2005820711 cites W1585170322 @default.
- W2005820711 cites W1824910897 @default.
- W2005820711 cites W1967263951 @default.
- W2005820711 cites W1967356976 @default.
- W2005820711 cites W1967818875 @default.
- W2005820711 cites W1970452315 @default.
- W2005820711 cites W1978102493 @default.
- W2005820711 cites W1981700333 @default.
- W2005820711 cites W1982664065 @default.
- W2005820711 cites W1991081070 @default.
- W2005820711 cites W1995629350 @default.
- W2005820711 cites W2005102860 @default.
- W2005820711 cites W2012272570 @default.
- W2005820711 cites W2012744652 @default.
- W2005820711 cites W2015449243 @default.
- W2005820711 cites W2029565975 @default.
- W2005820711 cites W2032246594 @default.
- W2005820711 cites W2037254336 @default.
- W2005820711 cites W2041170922 @default.
- W2005820711 cites W2041928346 @default.
- W2005820711 cites W2043667001 @default.
- W2005820711 cites W2064027072 @default.
- W2005820711 cites W2068977602 @default.
- W2005820711 cites W2073731887 @default.
- W2005820711 cites W2076483844 @default.
- W2005820711 cites W2078621117 @default.
- W2005820711 cites W2079936328 @default.
- W2005820711 cites W2090859543 @default.
- W2005820711 cites W2091151108 @default.
- W2005820711 cites W2094720153 @default.
- W2005820711 cites W2098142645 @default.
- W2005820711 cites W2104722369 @default.
- W2005820711 cites W2111717604 @default.
- W2005820711 cites W2113326101 @default.
- W2005820711 cites W2122093149 @default.
- W2005820711 cites W2126880379 @default.
- W2005820711 cites W2127136381 @default.
- W2005820711 cites W2127303484 @default.
- W2005820711 cites W2129958874 @default.
- W2005820711 cites W2131674777 @default.
- W2005820711 cites W2132482634 @default.
- W2005820711 cites W2136736147 @default.
- W2005820711 cites W2138067578 @default.
- W2005820711 cites W2140906887 @default.
- W2005820711 cites W2145025818 @default.
- W2005820711 cites W2159797569 @default.
- W2005820711 cites W2168203604 @default.
- W2005820711 cites W2169476570 @default.
- W2005820711 doi "https://doi.org/10.1111/j.1462-5822.2008.01189.x" @default.
- W2005820711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4966886" @default.
- W2005820711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18549453" @default.
- W2005820711 hasPublicationYear "2008" @default.
- W2005820711 type Work @default.
- W2005820711 sameAs 2005820711 @default.
- W2005820711 citedByCount "77" @default.
- W2005820711 countsByYear W20058207112012 @default.
- W2005820711 countsByYear W20058207112013 @default.
- W2005820711 countsByYear W20058207112014 @default.
- W2005820711 countsByYear W20058207112015 @default.
- W2005820711 countsByYear W20058207112016 @default.
- W2005820711 countsByYear W20058207112017 @default.
- W2005820711 countsByYear W20058207112018 @default.
- W2005820711 countsByYear W20058207112019 @default.
- W2005820711 countsByYear W20058207112020 @default.
- W2005820711 countsByYear W20058207112021 @default.
- W2005820711 countsByYear W20058207112022 @default.
- W2005820711 countsByYear W20058207112023 @default.
- W2005820711 crossrefType "journal-article" @default.
- W2005820711 hasAuthorship W2005820711A5019030969 @default.
- W2005820711 hasAuthorship W2005820711A5021272565 @default.
- W2005820711 hasAuthorship W2005820711A5028744677 @default.
- W2005820711 hasAuthorship W2005820711A5036791262 @default.
- W2005820711 hasAuthorship W2005820711A5040117830 @default.
- W2005820711 hasAuthorship W2005820711A5044929807 @default.
- W2005820711 hasAuthorship W2005820711A5056364356 @default.
- W2005820711 hasAuthorship W2005820711A5072425924 @default.
- W2005820711 hasAuthorship W2005820711A5080149508 @default.
- W2005820711 hasBestOaLocation W20058207111 @default.
- W2005820711 hasConcept C136449434 @default.
- W2005820711 hasConcept C164027704 @default.
- W2005820711 hasConcept C202751555 @default.
- W2005820711 hasConcept C203014093 @default.