FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005855950> ?p ?o ?g. }

• W2005855950 endingPage "361" @default.
• W2005855950 startingPage "355" @default.
• W2005855950 abstract "1 Pacemaker cells, known as interstitial cells of Cajal (ICC), generate electrical rhythmicity in the gastrointestinal tract. Pacemaker currents in ICC result from the activation of a voltage-independent, non-selective cation conductance, but the timing mechanism responsible for periodic activation of the pacemaker current is unknown. 2 Previous studies suggest that pacemaking in ICC is dependent upon metabolic activity 1y1yand1 Ca2+ release from intracellular stores. We tested the hypothesis that mitochondrial Ca2+ handling may underlie the dependence of gastrointestinal pacemaking on oxidative metabolism. 3 Pacemaker currents occurred spontaneously in cultured ICC and were associated with mitochondrial Ca2+ transients. 4 Inhibition of the electrochemical gradient across the inner mitochondrial membrane blocked Ca2+ uptake and pacemaker currents in cultured ICC and blocked slow wave activity in intact gastrointestinal muscles from mouse, dog and guinea-pig. 5 Pacemaker currents and rhythmic mitochondrial Ca2+ uptake in ICC were also blocked by inhibitors of IP3-dependent release of Ca2+ from the endoplasmic reticulum and by inhibitors of endoplasmic reticulum Ca2+ reuptake. 6 Our data suggest that integrated Ca2+ handling by endoplasmic reticulum and mitochondria is a prerequisite of electrical pacemaking in the gastrointestinal tract." @default.
• W2005855950 created "2016-06-24" @default.
• W2005855950 creator A5000504171 @default.
• W2005855950 creator A5013959962 @default.
• W2005855950 creator A5028080442 @default.
• W2005855950 creator A5031123252 @default.
• W2005855950 creator A5031664614 @default.
• W2005855950 creator A5037646851 @default.
• W2005855950 creator A5055296224 @default.
• W2005855950 creator A5086893409 @default.
• W2005855950 date "2000-06-01" @default.
• W2005855950 modified "2023-09-25" @default.
• W2005855950 title "Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria" @default.
• W2005855950 cites W1559795048 @default.
• W2005855950 cites W1581232786 @default.
• W2005855950 cites W1604805265 @default.
• W2005855950 cites W1935060748 @default.
• W2005855950 cites W1968789295 @default.
• W2005855950 cites W1977150932 @default.
• W2005855950 cites W1980166477 @default.
• W2005855950 cites W1988530903 @default.
• W2005855950 cites W1991175004 @default.
• W2005855950 cites W2014797523 @default.
• W2005855950 cites W2027636000 @default.
• W2005855950 cites W2029547669 @default.
• W2005855950 cites W2046353863 @default.
• W2005855950 cites W2048142140 @default.
• W2005855950 cites W2049314578 @default.
• W2005855950 cites W2056614650 @default.
• W2005855950 cites W2066938884 @default.
• W2005855950 cites W2070664966 @default.
• W2005855950 cites W2073706613 @default.
• W2005855950 cites W2086040128 @default.
• W2005855950 cites W2090509794 @default.
• W2005855950 cites W2092109656 @default.
• W2005855950 cites W2094649746 @default.
• W2005855950 cites W2103105379 @default.
• W2005855950 cites W2114228694 @default.
• W2005855950 cites W2128497087 @default.
• W2005855950 cites W2163529058 @default.
• W2005855950 cites W2164872793 @default.
• W2005855950 cites W2253283819 @default.
• W2005855950 cites W2886058976 @default.
• W2005855950 doi "https://doi.org/10.1111/j.1469-7793.2000.t01-1-00355.x" @default.
• W2005855950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269944" @default.
• W2005855950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10835039" @default.
• W2005855950 hasPublicationYear "2000" @default.
• W2005855950 type Work @default.
• W2005855950 sameAs 2005855950 @default.
• W2005855950 citedByCount "284" @default.
• W2005855950 countsByYear W20058559502012 @default.
• W2005855950 countsByYear W20058559502013 @default.
• W2005855950 countsByYear W20058559502014 @default.
• W2005855950 countsByYear W20058559502015 @default.
• W2005855950 countsByYear W20058559502016 @default.
• W2005855950 countsByYear W20058559502017 @default.
• W2005855950 countsByYear W20058559502018 @default.
• W2005855950 countsByYear W20058559502019 @default.
• W2005855950 countsByYear W20058559502020 @default.
• W2005855950 countsByYear W20058559502021 @default.
• W2005855950 countsByYear W20058559502022 @default.
• W2005855950 countsByYear W20058559502023 @default.
• W2005855950 crossrefType "journal-article" @default.
• W2005855950 hasAuthorship W2005855950A5000504171 @default.
• W2005855950 hasAuthorship W2005855950A5013959962 @default.
• W2005855950 hasAuthorship W2005855950A5028080442 @default.
• W2005855950 hasAuthorship W2005855950A5031123252 @default.
• W2005855950 hasAuthorship W2005855950A5031664614 @default.
• W2005855950 hasAuthorship W2005855950A5037646851 @default.
• W2005855950 hasAuthorship W2005855950A5055296224 @default.
• W2005855950 hasAuthorship W2005855950A5086893409 @default.
• W2005855950 hasBestOaLocation W20058559501 @default.
• W2005855950 hasConcept C12554922 @default.
• W2005855950 hasConcept C126322002 @default.
• W2005855950 hasConcept C134018914 @default.
• W2005855950 hasConcept C142579037 @default.
• W2005855950 hasConcept C158617107 @default.
• W2005855950 hasConcept C177832589 @default.
• W2005855950 hasConcept C181911157 @default.
• W2005855950 hasConcept C185592680 @default.
• W2005855950 hasConcept C201539569 @default.
• W2005855950 hasConcept C28859421 @default.
• W2005855950 hasConcept C2992686903 @default.
• W2005855950 hasConcept C519063684 @default.
• W2005855950 hasConcept C71924100 @default.
• W2005855950 hasConcept C79879829 @default.
• W2005855950 hasConcept C86803240 @default.
• W2005855950 hasConcept C95444343 @default.
• W2005855950 hasConceptScore W2005855950C12554922 @default.
• W2005855950 hasConceptScore W2005855950C126322002 @default.
• W2005855950 hasConceptScore W2005855950C134018914 @default.
• W2005855950 hasConceptScore W2005855950C142579037 @default.
• W2005855950 hasConceptScore W2005855950C158617107 @default.
• W2005855950 hasConceptScore W2005855950C177832589 @default.
• W2005855950 hasConceptScore W2005855950C181911157 @default.
• W2005855950 hasConceptScore W2005855950C185592680 @default.
• W2005855950 hasConceptScore W2005855950C201539569 @default.
• W2005855950 hasConceptScore W2005855950C28859421 @default.

• next