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• W2005861566 abstract "Autophagy is a tightly controlled degradation process involved in various developmental aspects of eukaryotes. However, its involvement in developmental processes of multicellular filamentous ascomycetes is largely unknown. Here, we analyzed the impact of the autophagic proteins SmATG8 and SmATG4 on the sexual and vegetative development of the filamentous ascomycete Sordaria macrospora. A Saccharomyces cerevisiae complementation assay demonstrated that the S. macrospora Smatg8 and Smatg4 genes can functionally replace the yeast homologs. By generating homokaryotic deletion mutants, we showed that the S. macrospora SmATG8 and SmATG4 orthologs were associated with autophagy-dependent processes. Smatg8 and Smatg4 deletions abolished fruiting-body formation and impaired vegetative growth and ascospore germination, but not hyphal fusion. We demonstrated that SmATG4 was capable of processing the SmATG8 precursor. SmATG8 was localized to autophagosomes, whereas SmATG4 was distributed throughout the cytoplasm of S. macrospora. Furthermore, we could show that Smatg8 and Smatg4 are not only required for nonselective macroautophagy, but for selective macropexophagy as well. Taken together, our results suggest that in S. macrospora, autophagy seems to be an essential and constitutively active process to sustain high energy levels for filamentous growth and multicellular development even under nonstarvation conditions." @default.
• W2005861566 created "2016-06-24" @default.
• W2005861566 creator A5077011423 @default.
• W2005861566 creator A5085994956 @default.
• W2005861566 date "2013-01-09" @default.
• W2005861566 modified "2023-10-12" @default.
• W2005861566 title "Autophagy genes<i><i>Smatg8</i></i>and<i><i>Smatg4</i></i>are required for fruiting-body development, vegetative growth and ascospore germination in the filamentous ascomycete<i><i>Sordaria macrospora</i></i>" @default.
• W2005861566 cites W1487820517 @default.
• W2005861566 cites W1502170122 @default.
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• W2005861566 cites W1555054913 @default.
• W2005861566 cites W1585976221 @default.
• W2005861566 cites W1587475803 @default.
• W2005861566 cites W1594399374 @default.
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• W2005861566 cites W1917272836 @default.
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• W2005861566 cites W1978730497 @default.
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• W2005861566 cites W2072133622 @default.
• W2005861566 cites W2073059521 @default.
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• W2005861566 doi "https://doi.org/10.4161/auto.22398" @default.
• W2005861566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3542216" @default.
• W2005861566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23064313" @default.
• W2005861566 hasPublicationYear "2013" @default.
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