FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005862004> ?p ?o ?g. }

• W2005862004 endingPage "43" @default.
• W2005862004 startingPage "35" @default.
• W2005862004 abstract "Autosomal dominant cerebellar ataxias (ADCAs) are a complex group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. The spinocerebellar ataxia type 7 (SCA7) is associated with pigmentary macular dystrophy and retinal degeneration leading to blindness caused by a CAG/polyglutamine (polyGln) expansion in the coding region of the SCA7 gene/protein. The SCA7 gene codes for ataxin-7, a protein of unknown function. To investigate its cellular and subcellular localization, we have developed a sequence-specific polyclonal antibody against the N-terminal part of the protein. Immunohistochemical analysis indicated that ataxin-7 accumulates as single nuclear inclusion (NI) in the cells of the brain and retina of a SCA7 patient but not of controls. The 1C2 antibody, directed against expanded polyGln, confirmed the aggregation of mutant ataxin-7 in these NIs. Furthermore, ubiquitin was found in these aggregates, suggesting that mutant ataxin-7 is a target for ubiquitin-dependent proteolysis, but resistant to removal. Electron microscopic studies using immunogold labeling showed that ataxin-7 immunoreactive NIs appear as dense aggregates containing a mixture of granular and filamentary structures. Together, these data confirm the presence of NIs in brain and retina of a SCA7 patient, a common characteristic of disorders caused by expanded CAG/polyGln repeats." @default.
• W2005862004 created "2016-06-24" @default.
• W2005862004 creator A5012454874 @default.
• W2005862004 creator A5024899502 @default.
• W2005862004 creator A5039639102 @default.
• W2005862004 creator A5040603856 @default.
• W2005862004 creator A5053536269 @default.
• W2005862004 creator A5067125302 @default.
• W2005862004 date "1999-12-01" @default.
• W2005862004 modified "2023-10-12" @default.
• W2005862004 title "Identification and localization of ataxin-7 in brain and retina of a patient with cerebellar ataxia type II using anti-peptide antibody" @default.
• W2005862004 cites W1622884348 @default.
• W2005862004 cites W1971047357 @default.
• W2005862004 cites W1975483166 @default.
• W2005862004 cites W1985474993 @default.
• W2005862004 cites W1989619236 @default.
• W2005862004 cites W2012442320 @default.
• W2005862004 cites W2012481532 @default.
• W2005862004 cites W2013029120 @default.
• W2005862004 cites W2019855110 @default.
• W2005862004 cites W2021549542 @default.
• W2005862004 cites W2039376206 @default.
• W2005862004 cites W2042716629 @default.
• W2005862004 cites W2052883021 @default.
• W2005862004 cites W2056807785 @default.
• W2005862004 cites W2058543711 @default.
• W2005862004 cites W2064551580 @default.
• W2005862004 cites W2073012734 @default.
• W2005862004 cites W2078913984 @default.
• W2005862004 cites W2079813087 @default.
• W2005862004 cites W2099562440 @default.
• W2005862004 cites W2101411281 @default.
• W2005862004 cites W2107632226 @default.
• W2005862004 cites W2113333419 @default.
• W2005862004 cites W2115155228 @default.
• W2005862004 cites W2117120482 @default.
• W2005862004 cites W2121642311 @default.
• W2005862004 cites W2136299983 @default.
• W2005862004 cites W2140112946 @default.
• W2005862004 cites W2150889831 @default.
• W2005862004 cites W2155961722 @default.
• W2005862004 cites W2157513658 @default.
• W2005862004 cites W2168302341 @default.
• W2005862004 cites W2255469197 @default.
• W2005862004 cites W4252368281 @default.
• W2005862004 doi "https://doi.org/10.1016/s0169-328x(99)00256-9" @default.
• W2005862004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10640674" @default.
• W2005862004 hasPublicationYear "1999" @default.
• W2005862004 type Work @default.
• W2005862004 sameAs 2005862004 @default.
• W2005862004 citedByCount "48" @default.
• W2005862004 countsByYear W20058620042012 @default.
• W2005862004 countsByYear W20058620042013 @default.
• W2005862004 countsByYear W20058620042015 @default.
• W2005862004 countsByYear W20058620042018 @default.
• W2005862004 countsByYear W20058620042019 @default.
• W2005862004 countsByYear W20058620042021 @default.
• W2005862004 countsByYear W20058620042022 @default.
• W2005862004 countsByYear W20058620042023 @default.
• W2005862004 crossrefType "journal-article" @default.
• W2005862004 hasAuthorship W2005862004A5012454874 @default.
• W2005862004 hasAuthorship W2005862004A5024899502 @default.
• W2005862004 hasAuthorship W2005862004A5039639102 @default.
• W2005862004 hasAuthorship W2005862004A5040603856 @default.
• W2005862004 hasAuthorship W2005862004A5053536269 @default.
• W2005862004 hasAuthorship W2005862004A5067125302 @default.
• W2005862004 hasConcept C142724271 @default.
• W2005862004 hasConcept C153911025 @default.
• W2005862004 hasConcept C169760540 @default.
• W2005862004 hasConcept C2777093970 @default.
• W2005862004 hasConcept C2779500118 @default.
• W2005862004 hasConcept C2779652256 @default.
• W2005862004 hasConcept C2780148635 @default.
• W2005862004 hasConcept C2780906641 @default.
• W2005862004 hasConcept C2781040256 @default.
• W2005862004 hasConcept C71924100 @default.
• W2005862004 hasConcept C86803240 @default.
• W2005862004 hasConcept C95444343 @default.
• W2005862004 hasConceptScore W2005862004C142724271 @default.
• W2005862004 hasConceptScore W2005862004C153911025 @default.
• W2005862004 hasConceptScore W2005862004C169760540 @default.
• W2005862004 hasConceptScore W2005862004C2777093970 @default.
• W2005862004 hasConceptScore W2005862004C2779500118 @default.
• W2005862004 hasConceptScore W2005862004C2779652256 @default.
• W2005862004 hasConceptScore W2005862004C2780148635 @default.
• W2005862004 hasConceptScore W2005862004C2780906641 @default.
• W2005862004 hasConceptScore W2005862004C2781040256 @default.
• W2005862004 hasConceptScore W2005862004C71924100 @default.
• W2005862004 hasConceptScore W2005862004C86803240 @default.
• W2005862004 hasConceptScore W2005862004C95444343 @default.
• W2005862004 hasIssue "1-2" @default.
• W2005862004 hasLocation W20058620041 @default.
• W2005862004 hasLocation W20058620042 @default.
• W2005862004 hasOpenAccess W2005862004 @default.
• W2005862004 hasPrimaryLocation W20058620041 @default.
• W2005862004 hasRelatedWork W2019983375 @default.
• W2005862004 hasRelatedWork W2033545352 @default.
• W2005862004 hasRelatedWork W2088525571 @default.

• next