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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005876409> ?p ?o ?g. }

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• W2005876409 abstract "The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor which requires heterodimerization with the Ah receptor nuclear translocator (Arnt) for function. Arnt is also a dimerization partner of the hypoxia inducible factor 1alpha (HIF-1alpha) for the hypoxia signaling. Additionally, Arnt is found to be a potent coactivator of the estrogen receptor (ER) signaling. Thus we examined whether the presence of an increased amount of AhR may suppress both the HIF-1alpha and ER signaling pathways by sequestering Arnt. We tested our hypothesis using a human AhR construct C Delta553 which is capable of heterodimerizing with Arnt in the absence of a ligand. Transient transfection studies using a corresponding luciferase reporter plasmid in MCF-7 cells showed that C Delta553 effectively suppressed the AhR, HIF-1alpha, and ER signaling pathways. Reverse transcription/real-time QPCR data showed that C Delta553 blocked the up-regulation of the target genes controlled by AhR (CYP1A1), HIF-1alpha (VEGF, aldolase C, and LDH-A), and ER (GREB1, pS2, and c-myc) in MCF-7 cells. Since both HIF-1alpha and ER are highly active in the ER-positive breast cancer, C Delta553 has the potential to be developed as a protein drug to treat breast cancer by blocking these two signaling pathways." @default.
• W2005876409 created "2016-06-24" @default.
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• W2005876409 date "2006-11-08" @default.
• W2005876409 modified "2023-09-26" @default.
• W2005876409 title "A Truncated Ah Receptor Blocks the Hypoxia and Estrogen Receptor Signaling Pathways: A Viable Approach for Breast Cancer Treatment" @default.
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• W2005876409 doi "https://doi.org/10.1021/mp0600438" @default.
• W2005876409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2761706" @default.
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