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- W2005883632 abstract "Adult intact, or castrated testosterone propionate (TP, 150 μg/kg) treated male rats, were tested for masculine sexual behavior after having been injected with 5,7-dihydroxytryptamine (5,7-DHT, 4 μg/4 ml) intracerebrally either alone or in combination with systemic treatment with protriptyline, a noradrenaline (NA) re-uptake blocking agent. No changes were found in the sexual behavior of intact rats although the brain 5-HT levels were reduced to about one-third of their normal value. By contrast, there was a marked increase in the proportion of rats showing ejaculation patterns in the castrate + TP group after 5,7-DHT lesion than in the vehicle-injected group. Compared to the control group, the 5,7-DHT group showed a reduced uptake of [3H]5-HT and [3H]NA in the hypothalamus. Also the uptake of [3H]amines in the cerebral cortex was lowered although the difference did not attain statistical significance. A statistically significant relationship was found between the behavioral changes and the reduction of [3H]5-HT uptake in the hypothalamus while no such relationship was found between the NA uptake and the behavioral changes. Tistochemical analysis of the site of the 5,7-DHT injections showed that the unspecific damage (nerve cell loss, glial cell infiltration) involved a somewhat larger area in the 5,7-DHT group than in the controls. These unspecific lesions were, however, located outside the region of the large medial 5-HT bundle. The results support the hypothesis that 5-HT serves as a transmitter in the neural processes underlying masculine sexual behavior and, further, points to one component of the ascending 5-HT projections which innervates inter alia the hypothalamus as being of particular importance in this context." @default.
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- W2005883632 date "1978-02-01" @default.
- W2005883632 modified "2023-09-26" @default.
- W2005883632 title "Sexual behavior in male rats after intracerebral injection of 5,7-dihydroxytryptamine" @default.
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- W2005883632 doi "https://doi.org/10.1016/0006-8993(78)90199-3" @default.
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