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- W2005909548 abstract "Host pattern recognition receptors (PRRs) recognize invading viral pathogens and initiate a series of signaling cascades that lead to the expression of type I interferons (IFNs) and inflammatory cytokines. During the past decade, significant progresses have been made to characterize PRRs such as Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) and elucidate the molecular mechanisms of TLR- and RLR-mediated signaling. To avoid excessive and harmful immune effects caused by over-activation of these signaling pathways, host cells adopt a number of strategies to regulate them. In addition, invading viruses also employ a variety of mechanisms to inhibit the production of type I IFNs, thereby evading the supervision and clearance by the host. In this review, we briefly summarize the TLR- and RLR-mediated type I IFN signaling and then focus on the mechanisms by which host cellular and viral components regulate the expression of type I IFNs." @default.
- W2005909548 created "2016-06-24" @default.
- W2005909548 creator A5000618507 @default.
- W2005909548 creator A5077483225 @default.
- W2005909548 creator A5079030954 @default.
- W2005909548 date "2010-02-01" @default.
- W2005909548 modified "2023-09-26" @default.
- W2005909548 title "Regulation of virus-triggered type I interferon signaling by cellular and viral proteins" @default.
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