FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005917830> ?p ?o ?g. }

• W2005917830 endingPage "176" @default.
• W2005917830 startingPage "173" @default.
• W2005917830 abstract "The Mycobacterium simiae complex bacteria can cause opportunistic infections in humans. In the case of definite disease, there are no evidence-based treatment regimens and outcomes are very disappointing. To increase the evidence base underpinning treatment regimens for M. simiae complex disease, drug susceptibility patterns and rifampicin/ethambutol synergy were assessed retrospectively in 69 clinical M. simiae complex isolates from 60 patients (22 patients with M. simiae, 24 with Mycobacterium lentiflavum, 8 with Mycobacterium triplex, 5 with Mycobacterium parascrofulaceum and 1 with Mycobacterium stomatepiae) submitted to the mycobacteriology laboratory at National Jewish Health (Denver, CO). Quantitative drug susceptibility testing (DST) was performed using the radiometric BacTec 460 macrodilution method. Results were related to pharmacokinetic (PK) measurements, where available. All M. simiae complex species proved susceptible to clarithromycin and, to a lesser extent, rifabutin, clofazimine, streptomycin and moxifloxacin. Synergy or additive action between rifampicin and ethambutol was observed for all species except M. simiae. Mycobacterium simiae is poorly susceptible in vitro to rifampicin and ethambutol alone as well as in combination; PK measurements support the limited efficacy of these drugs against M. simiae. The triple-drug regimen of a rifamycin, ethambutol and a macrolide may be advised to treat disease caused by M. lentiflavum, M. triplex, M. parascrofulaceum and M. stomatepiae; for M. simiae, this regimen appears less active. These findings may partly explain the limited treatment results in M. simiae disease. A treatment regimen including a macrolide, moxifloxacin and one or two additional drugs based on DST results may be advisable; clofazimine and amikacin or streptomycin are potential candidates." @default.
• W2005917830 created "2016-06-24" @default.
• W2005917830 creator A5006121849 @default.
• W2005917830 creator A5009819640 @default.
• W2005917830 creator A5010141975 @default.
• W2005917830 creator A5043545283 @default.
• W2005917830 creator A5080158752 @default.
• W2005917830 date "2012-02-01" @default.
• W2005917830 modified "2023-10-06" @default.
• W2005917830 title "Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease" @default.
• W2005917830 cites W1741355380 @default.
• W2005917830 cites W1955005444 @default.
• W2005917830 cites W1993911058 @default.
• W2005917830 cites W2029134494 @default.
• W2005917830 cites W2113350593 @default.
• W2005917830 cites W2113560142 @default.
• W2005917830 cites W2127699521 @default.
• W2005917830 cites W2128067448 @default.
• W2005917830 cites W2129086230 @default.
• W2005917830 cites W2130317722 @default.
• W2005917830 cites W2142447693 @default.
• W2005917830 cites W2144366236 @default.
• W2005917830 cites W2146832771 @default.
• W2005917830 cites W2147213334 @default.
• W2005917830 cites W2169333662 @default.
• W2005917830 doi "https://doi.org/10.1016/j.ijantimicag.2011.09.019" @default.
• W2005917830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22099521" @default.
• W2005917830 hasPublicationYear "2012" @default.
• W2005917830 type Work @default.
• W2005917830 sameAs 2005917830 @default.
• W2005917830 citedByCount "63" @default.
• W2005917830 countsByYear W20059178302012 @default.
• W2005917830 countsByYear W20059178302013 @default.
• W2005917830 countsByYear W20059178302014 @default.
• W2005917830 countsByYear W20059178302015 @default.
• W2005917830 countsByYear W20059178302016 @default.
• W2005917830 countsByYear W20059178302017 @default.
• W2005917830 countsByYear W20059178302018 @default.
• W2005917830 countsByYear W20059178302019 @default.
• W2005917830 countsByYear W20059178302020 @default.
• W2005917830 countsByYear W20059178302021 @default.
• W2005917830 countsByYear W20059178302022 @default.
• W2005917830 countsByYear W20059178302023 @default.
• W2005917830 crossrefType "journal-article" @default.
• W2005917830 hasAuthorship W2005917830A5006121849 @default.
• W2005917830 hasAuthorship W2005917830A5009819640 @default.
• W2005917830 hasAuthorship W2005917830A5010141975 @default.
• W2005917830 hasAuthorship W2005917830A5043545283 @default.
• W2005917830 hasAuthorship W2005917830A5080158752 @default.
• W2005917830 hasConcept C126322002 @default.
• W2005917830 hasConcept C203014093 @default.
• W2005917830 hasConcept C2775843808 @default.
• W2005917830 hasConcept C2776228421 @default.
• W2005917830 hasConcept C2776297342 @default.
• W2005917830 hasConcept C2776962512 @default.
• W2005917830 hasConcept C2778607973 @default.
• W2005917830 hasConcept C2778836808 @default.
• W2005917830 hasConcept C2780695269 @default.
• W2005917830 hasConcept C2780867798 @default.
• W2005917830 hasConcept C2781413609 @default.
• W2005917830 hasConcept C3019249092 @default.
• W2005917830 hasConcept C501593827 @default.
• W2005917830 hasConcept C71924100 @default.
• W2005917830 hasConcept C86803240 @default.
• W2005917830 hasConcept C89423630 @default.
• W2005917830 hasConceptScore W2005917830C126322002 @default.
• W2005917830 hasConceptScore W2005917830C203014093 @default.
• W2005917830 hasConceptScore W2005917830C2775843808 @default.
• W2005917830 hasConceptScore W2005917830C2776228421 @default.
• W2005917830 hasConceptScore W2005917830C2776297342 @default.
• W2005917830 hasConceptScore W2005917830C2776962512 @default.
• W2005917830 hasConceptScore W2005917830C2778607973 @default.
• W2005917830 hasConceptScore W2005917830C2778836808 @default.
• W2005917830 hasConceptScore W2005917830C2780695269 @default.
• W2005917830 hasConceptScore W2005917830C2780867798 @default.
• W2005917830 hasConceptScore W2005917830C2781413609 @default.
• W2005917830 hasConceptScore W2005917830C3019249092 @default.
• W2005917830 hasConceptScore W2005917830C501593827 @default.
• W2005917830 hasConceptScore W2005917830C71924100 @default.
• W2005917830 hasConceptScore W2005917830C86803240 @default.
• W2005917830 hasConceptScore W2005917830C89423630 @default.
• W2005917830 hasIssue "2" @default.
• W2005917830 hasLocation W20059178301 @default.
• W2005917830 hasLocation W20059178302 @default.
• W2005917830 hasOpenAccess W2005917830 @default.
• W2005917830 hasPrimaryLocation W20059178301 @default.
• W2005917830 hasRelatedWork W1970767855 @default.
• W2005917830 hasRelatedWork W2005917830 @default.
• W2005917830 hasRelatedWork W2102173040 @default.
• W2005917830 hasRelatedWork W2132212980 @default.
• W2005917830 hasRelatedWork W2161872750 @default.
• W2005917830 hasRelatedWork W2399813431 @default.
• W2005917830 hasRelatedWork W2408821081 @default.
• W2005917830 hasRelatedWork W2415329991 @default.
• W2005917830 hasRelatedWork W3208747835 @default.
• W2005917830 hasRelatedWork W425774368 @default.
• W2005917830 hasVolume "39" @default.
• W2005917830 isParatext "false" @default.

• next