Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005946076> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2005946076 endingPage "55" @default.
- W2005946076 startingPage "49" @default.
- W2005946076 abstract "AE37F, a new aminotetrahydrofuranic derivative, exhibited, at 10-30 mg/Kg (po) or 1-10 mg/Kg (ip), antagonism of tonic convulsions, induced by pentetrazole (130 mg/Kg, ip), and of forced swin immobility, in mice. At these doses AE37F induced a considerable (100-250%) increase of serotonin (5-HT) and its main metabolite, 5-hydroxyindolacetic acid (5-HIAA), in the rat nucleus reticularis pontis oralis (NRPO), antagonized by amantadine, which also increased 5-HT and 5-HIAA levels in the NRPO. It is suggested: a) that the anti-immobility effect of AE37F is related to its antimuscarinic properties, b) that the rate of 5-HT release in the NRPO, calculated here by a new approach (from the 5-HT and 5-HIAA brain levels) is increased by AE37F and decreased by amantadine, in the NRPO, c) that the anti-convulsant action, observed with AE37F, could be related to a NMDA-sigma mediated stimulation of serotoninergic, GABAergic and glycinergic brain neurones, antagonized by the NMDA-sigma inhibition induced by amantadine." @default.
- W2005946076 created "2016-06-24" @default.
- W2005946076 creator A5005477580 @default.
- W2005946076 creator A5062188933 @default.
- W2005946076 creator A5074814128 @default.
- W2005946076 date "2004-01-01" @default.
- W2005946076 modified "2023-10-16" @default.
- W2005946076 title "Mécanisme d’action des effets anticonvulsivant et anti-immobilité (nage forcée) de la 3’, 4’-dihydro-N, N-diméthylspiro [9H-fluorène-9, 2’ (5’H)- furane] - 3’-méthanamine (AE37F)" @default.
- W2005946076 cites W108475068 @default.
- W2005946076 cites W133999375 @default.
- W2005946076 cites W1970292931 @default.
- W2005946076 cites W1970503530 @default.
- W2005946076 cites W1979742154 @default.
- W2005946076 cites W1981102082 @default.
- W2005946076 cites W1981199626 @default.
- W2005946076 cites W1982786179 @default.
- W2005946076 cites W1992818207 @default.
- W2005946076 cites W2005593490 @default.
- W2005946076 cites W2006748961 @default.
- W2005946076 cites W2013164642 @default.
- W2005946076 cites W2013947104 @default.
- W2005946076 cites W2014956929 @default.
- W2005946076 cites W2018691353 @default.
- W2005946076 cites W2021604187 @default.
- W2005946076 cites W2026083845 @default.
- W2005946076 cites W2031242571 @default.
- W2005946076 cites W2050620515 @default.
- W2005946076 cites W2052202091 @default.
- W2005946076 cites W2052376597 @default.
- W2005946076 cites W2062703583 @default.
- W2005946076 cites W2080718222 @default.
- W2005946076 cites W2086322786 @default.
- W2005946076 cites W2090271222 @default.
- W2005946076 cites W2093695516 @default.
- W2005946076 cites W2093755310 @default.
- W2005946076 cites W2100757379 @default.
- W2005946076 cites W2121413985 @default.
- W2005946076 cites W2337352312 @default.
- W2005946076 cites W2411205951 @default.
- W2005946076 cites W2411319299 @default.
- W2005946076 cites W2412429876 @default.
- W2005946076 cites W2432665379 @default.
- W2005946076 cites W2466278180 @default.
- W2005946076 cites W2949130857 @default.
- W2005946076 cites W2464731771 @default.
- W2005946076 doi "https://doi.org/10.1016/s0003-4509(04)94281-2" @default.
- W2005946076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14747773" @default.
- W2005946076 hasPublicationYear "2004" @default.
- W2005946076 type Work @default.
- W2005946076 sameAs 2005946076 @default.
- W2005946076 citedByCount "2" @default.
- W2005946076 crossrefType "journal-article" @default.
- W2005946076 hasAuthorship W2005946076A5005477580 @default.
- W2005946076 hasAuthorship W2005946076A5062188933 @default.
- W2005946076 hasAuthorship W2005946076A5074814128 @default.
- W2005946076 hasConcept C170493617 @default.
- W2005946076 hasConcept C185592680 @default.
- W2005946076 hasConcept C2775864247 @default.
- W2005946076 hasConcept C37000724 @default.
- W2005946076 hasConcept C55493867 @default.
- W2005946076 hasConcept C86803240 @default.
- W2005946076 hasConcept C98274493 @default.
- W2005946076 hasConceptScore W2005946076C170493617 @default.
- W2005946076 hasConceptScore W2005946076C185592680 @default.
- W2005946076 hasConceptScore W2005946076C2775864247 @default.
- W2005946076 hasConceptScore W2005946076C37000724 @default.
- W2005946076 hasConceptScore W2005946076C55493867 @default.
- W2005946076 hasConceptScore W2005946076C86803240 @default.
- W2005946076 hasConceptScore W2005946076C98274493 @default.
- W2005946076 hasIssue "1" @default.
- W2005946076 hasLocation W20059460761 @default.
- W2005946076 hasLocation W20059460762 @default.
- W2005946076 hasOpenAccess W2005946076 @default.
- W2005946076 hasPrimaryLocation W20059460761 @default.
- W2005946076 hasRelatedWork W1998148889 @default.
- W2005946076 hasRelatedWork W2002025099 @default.
- W2005946076 hasRelatedWork W2014541695 @default.
- W2005946076 hasRelatedWork W2027364088 @default.
- W2005946076 hasRelatedWork W2068430322 @default.
- W2005946076 hasRelatedWork W2072185657 @default.
- W2005946076 hasRelatedWork W2081701126 @default.
- W2005946076 hasRelatedWork W2806574399 @default.
- W2005946076 hasRelatedWork W4281957879 @default.
- W2005946076 hasRelatedWork W80859649 @default.
- W2005946076 hasVolume "62" @default.
- W2005946076 isParatext "false" @default.
- W2005946076 isRetracted "false" @default.
- W2005946076 magId "2005946076" @default.
- W2005946076 workType "article" @default.