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- W2005949594 abstract "Members of the galectin family of endogenous lectins are involved in tumor growth regulation and in establishing characteristics of the malignant phenotype via protein-carbohydrate and protein-protein interactions. To identify peptide ligands with the potential to modulate these tumor-relevant interactions beneficially, complementary screening methods were employed, that is, both phage-display and a combinatorial pentapeptide library with the key YXY tripeptide core. Three representative prototype galectins were selected. The search for high-affinity ligands among phage-displayed random heptamers yielded enrichment after five selection cycles of the nonglycomimetic CQSPSARSC peptide in the case of the chicken homologue of galectin-1 but not the human protein, an indication for specificity. The most active glycomimetic from the combinatorial library of 5832 pentamers was WYKYW. Identification of peptide ligands for galectins with and without glycomimetic properties is thus possible. Our study documents the potential to combine the two library-based approaches for structural optimization of lead peptides." @default.
- W2005949594 created "2016-06-24" @default.
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- W2005949594 date "2005-01-01" @default.
- W2005949594 modified "2023-09-25" @default.
- W2005949594 title "Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries" @default.
- W2005949594 cites W117529435 @default.
- W2005949594 cites W1503857509 @default.
- W2005949594 cites W1591942886 @default.
- W2005949594 cites W1742680248 @default.
- W2005949594 cites W1963590611 @default.
- W2005949594 cites W1964992965 @default.
- W2005949594 cites W1965197287 @default.
- W2005949594 cites W1973202607 @default.
- W2005949594 cites W1973322293 @default.
- W2005949594 cites W1974580327 @default.
- W2005949594 cites W1978057604 @default.
- W2005949594 cites W198100803 @default.
- W2005949594 cites W1981213011 @default.
- W2005949594 cites W1983861347 @default.
- W2005949594 cites W1987817801 @default.
- W2005949594 cites W1988184759 @default.
- W2005949594 cites W1996418151 @default.
- W2005949594 cites W1998493826 @default.
- W2005949594 cites W2002355793 @default.
- W2005949594 cites W2004610998 @default.
- W2005949594 cites W2006319694 @default.
- W2005949594 cites W2006446936 @default.
- W2005949594 cites W2007378422 @default.
- W2005949594 cites W2007479564 @default.
- W2005949594 cites W2015898437 @default.
- W2005949594 cites W2016181996 @default.
- W2005949594 cites W2017337119 @default.
- W2005949594 cites W2017636598 @default.
- W2005949594 cites W2021514097 @default.
- W2005949594 cites W2021947685 @default.
- W2005949594 cites W2022710791 @default.
- W2005949594 cites W2032806769 @default.
- W2005949594 cites W2034759328 @default.
- W2005949594 cites W2036938579 @default.
- W2005949594 cites W2037011184 @default.
- W2005949594 cites W2040608320 @default.
- W2005949594 cites W2046057817 @default.
- W2005949594 cites W2046847478 @default.
- W2005949594 cites W2047658919 @default.
- W2005949594 cites W2048827022 @default.
- W2005949594 cites W2057134325 @default.
- W2005949594 cites W2059275298 @default.
- W2005949594 cites W2059984219 @default.
- W2005949594 cites W2060486111 @default.
- W2005949594 cites W2061386062 @default.
- W2005949594 cites W2062531547 @default.
- W2005949594 cites W2065870143 @default.
- W2005949594 cites W2066251525 @default.
- W2005949594 cites W2066975319 @default.
- W2005949594 cites W2068896180 @default.
- W2005949594 cites W2078108847 @default.
- W2005949594 cites W2079844004 @default.
- W2005949594 cites W2080921967 @default.
- W2005949594 cites W2086868992 @default.
- W2005949594 cites W2088026556 @default.
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- W2005949594 cites W2104467744 @default.
- W2005949594 cites W2112998064 @default.
- W2005949594 cites W2127826425 @default.
- W2005949594 cites W2136180478 @default.
- W2005949594 cites W2142800104 @default.
- W2005949594 cites W2143698601 @default.
- W2005949594 cites W2146565585 @default.
- W2005949594 cites W2150926065 @default.
- W2005949594 cites W2151227852 @default.
- W2005949594 cites W2157903759 @default.
- W2005949594 cites W2170032865 @default.
- W2005949594 cites W2317651936 @default.
- W2005949594 cites W2323664264 @default.
- W2005949594 cites W232368323 @default.
- W2005949594 cites W2950238768 @default.
- W2005949594 cites W4211068266 @default.
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- W2005949594 doi "https://doi.org/10.1016/j.bmc.2004.09.053" @default.
- W2005949594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15598577" @default.
- W2005949594 hasPublicationYear "2005" @default.
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