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- W2005955487 abstract "<b><i>Aims:</i></b> This study aimed to evaluate the different abilities of various <i>Phellinus igniarius</i> strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. <b><i>Methods:</i></b> The bioactive metabolites produced by <i>P. igniarius</i> cultures were tested for their abilities to inhibit QS-regulated behavior. All <i>P. igniarius</i> strains were cultured in potato-dextrose medium by large-scale submerged fermentation. The culture supernatant was condensed into 0.2-fold volumes by freeze drying. The condensed supernatant was sterilized by filtration through a 0.22-µm membrane filter and added to <i>Chromobacterium violaceum</i> CV026 cultures, which were used to monitor QS inhibition. Inhibitory activity was measured by quantifying violacein production using a microplate reader. <b><i>Results:</i></b> The bioactive metabolites produced by 10 <i>P. igniarius</i> strains could inhibit violacein production, a QS-regulated behavior in <i>C. violaceum</i>. Furthermore, these strains could be roughly categorized into three groups on the basis of their inhibitory activities. <b><i>Conclusions:</i></b><i>P. igniarius</i> strains can produce QS-inhibitory compounds and have different abilities to inhibit QS." @default.
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- W2005955487 date "2012-01-01" @default.
- W2005955487 modified "2023-09-30" @default.
- W2005955487 title "Evaluation of Anti-Quorum-Sensing Activity of Fermentation Metabolites from Different Strains of a Medicinal Mushroom, Phellinus igniarius" @default.
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- W2005955487 doi "https://doi.org/10.1159/000338383" @default.
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