Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005959013> ?p ?o ?g. }
- W2005959013 endingPage "135" @default.
- W2005959013 startingPage "129" @default.
- W2005959013 abstract "Genetics and diet interact to cause type 2 diabetes mellitus and obesity. PCK1 has been implicated as one of many genes associated with type 2 diabetes mellitus. The common assumption is that mutations in PCK1 lead to excessive glucose production through hepatic gluconeogenesis. However, there is an alternative explanation, wherein mutations at the PCK1 locus could selectively affect PCK1 expression in adipose tissue. The result would be changes in glyceroneogenesis that would affect the storage and release of fatty acids. Here, we present the novel hypothesis that a variety of phenotypes could arise from mutations of the various tissue-specific control elements of PCK1. We also suggest specific quantitative metabolic traits that would accompany mutations that selectively affect PCK1 expression in adipose tissue." @default.
- W2005959013 created "2016-06-24" @default.
- W2005959013 creator A5018144156 @default.
- W2005959013 creator A5044891277 @default.
- W2005959013 creator A5069274010 @default.
- W2005959013 creator A5077645715 @default.
- W2005959013 date "2004-04-01" @default.
- W2005959013 modified "2023-10-14" @default.
- W2005959013 title "Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene" @default.
- W2005959013 cites W1508641641 @default.
- W2005959013 cites W1515515318 @default.
- W2005959013 cites W1516091922 @default.
- W2005959013 cites W1583122397 @default.
- W2005959013 cites W1834811765 @default.
- W2005959013 cites W1969366784 @default.
- W2005959013 cites W1981100453 @default.
- W2005959013 cites W1983704964 @default.
- W2005959013 cites W1996166472 @default.
- W2005959013 cites W2006674727 @default.
- W2005959013 cites W2009411683 @default.
- W2005959013 cites W2010827268 @default.
- W2005959013 cites W2010920103 @default.
- W2005959013 cites W2013980940 @default.
- W2005959013 cites W2017688661 @default.
- W2005959013 cites W2018901358 @default.
- W2005959013 cites W2020050382 @default.
- W2005959013 cites W2025247302 @default.
- W2005959013 cites W2028219210 @default.
- W2005959013 cites W2032919742 @default.
- W2005959013 cites W2036344921 @default.
- W2005959013 cites W2044312952 @default.
- W2005959013 cites W2051827443 @default.
- W2005959013 cites W2059511498 @default.
- W2005959013 cites W2070359751 @default.
- W2005959013 cites W2075227013 @default.
- W2005959013 cites W2076330933 @default.
- W2005959013 cites W2077581706 @default.
- W2005959013 cites W2089788793 @default.
- W2005959013 cites W2091992445 @default.
- W2005959013 cites W2092966600 @default.
- W2005959013 cites W2106242976 @default.
- W2005959013 cites W2119472422 @default.
- W2005959013 cites W2120432009 @default.
- W2005959013 cites W2124697228 @default.
- W2005959013 cites W2125344994 @default.
- W2005959013 cites W2133208346 @default.
- W2005959013 cites W2134294998 @default.
- W2005959013 cites W2140633499 @default.
- W2005959013 cites W2156853294 @default.
- W2005959013 cites W2171952619 @default.
- W2005959013 cites W2196535922 @default.
- W2005959013 cites W2430143578 @default.
- W2005959013 doi "https://doi.org/10.1016/j.tem.2004.02.006" @default.
- W2005959013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15046742" @default.
- W2005959013 hasPublicationYear "2004" @default.
- W2005959013 type Work @default.
- W2005959013 sameAs 2005959013 @default.
- W2005959013 citedByCount "113" @default.
- W2005959013 countsByYear W20059590132012 @default.
- W2005959013 countsByYear W20059590132013 @default.
- W2005959013 countsByYear W20059590132014 @default.
- W2005959013 countsByYear W20059590132015 @default.
- W2005959013 countsByYear W20059590132016 @default.
- W2005959013 countsByYear W20059590132017 @default.
- W2005959013 countsByYear W20059590132018 @default.
- W2005959013 countsByYear W20059590132019 @default.
- W2005959013 countsByYear W20059590132020 @default.
- W2005959013 countsByYear W20059590132021 @default.
- W2005959013 countsByYear W20059590132022 @default.
- W2005959013 countsByYear W20059590132023 @default.
- W2005959013 crossrefType "journal-article" @default.
- W2005959013 hasAuthorship W2005959013A5018144156 @default.
- W2005959013 hasAuthorship W2005959013A5044891277 @default.
- W2005959013 hasAuthorship W2005959013A5069274010 @default.
- W2005959013 hasAuthorship W2005959013A5077645715 @default.
- W2005959013 hasConcept C104317684 @default.
- W2005959013 hasConcept C127716648 @default.
- W2005959013 hasConcept C134018914 @default.
- W2005959013 hasConcept C171089720 @default.
- W2005959013 hasConcept C2777180221 @default.
- W2005959013 hasConcept C2910068830 @default.
- W2005959013 hasConcept C511355011 @default.
- W2005959013 hasConcept C54355233 @default.
- W2005959013 hasConcept C555293320 @default.
- W2005959013 hasConcept C86803240 @default.
- W2005959013 hasConceptScore W2005959013C104317684 @default.
- W2005959013 hasConceptScore W2005959013C127716648 @default.
- W2005959013 hasConceptScore W2005959013C134018914 @default.
- W2005959013 hasConceptScore W2005959013C171089720 @default.
- W2005959013 hasConceptScore W2005959013C2777180221 @default.
- W2005959013 hasConceptScore W2005959013C2910068830 @default.
- W2005959013 hasConceptScore W2005959013C511355011 @default.
- W2005959013 hasConceptScore W2005959013C54355233 @default.
- W2005959013 hasConceptScore W2005959013C555293320 @default.
- W2005959013 hasConceptScore W2005959013C86803240 @default.
- W2005959013 hasIssue "3" @default.
- W2005959013 hasLocation W20059590131 @default.
- W2005959013 hasLocation W20059590132 @default.