Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005959147> ?p ?o ?g. }
- W2005959147 endingPage "143" @default.
- W2005959147 startingPage "135" @default.
- W2005959147 abstract "ABSTRACT Many of the effects of dioxins, which are potent environmental pollutants and teratogens, are mediated through the aryl hydrocarbon receptor, also known as the dioxin receptor. The purpose of the present study was to characterize dioxin‐responsive genes in a comprehensive manner using two complementary approaches: bioinformatic analysis and microarray analysis. First, we characterized the overall distribution of the cis ‐regulatory element for the dioxin‐responsive element sequence (DRE) ‘gcgtg’ within putative promoter regions. We assembled the upstream sequences 10 kb from the transcription start site and evaluated their location and frequency in the human and mouse genomes. Second, we characterized the expression profile of mouse embryonic day 12 fetal brain exposed to 2,3,7,8‐tetrarchlorodibenzo‐p‐dioxin. The distributions of 26 680 DREs among 2843 human genes and 98 711 DREs among 18 541 mouse genes were examined. In both species, the DREs tended to be located close to the transcription start site. Forty genes exhibited significant induction or repression following dioxin exposure in fetal mice. The set of genes exhibited a strong functional coherence, with statistically significant enrichment in organogenesis and the DNA‐dependent regulation of transcription, according to Gene Ontology annotations. In both humans and mice, DREs were preferentially distributed close to transcription start sites. Evolutionary conservation of this unique DRE distribution pattern suggests that DREs may be involved in transcriptional regulation. In mice, prenatal dioxin exposure altered the expression of 10 transcription factors, many of which have been documented to play a role in organogenesis. These genes may represent potential mediators of dioxin’s effects in fetal tissues." @default.
- W2005959147 created "2016-06-24" @default.
- W2005959147 creator A5015575713 @default.
- W2005959147 creator A5026657616 @default.
- W2005959147 creator A5031252181 @default.
- W2005959147 creator A5063839512 @default.
- W2005959147 creator A5069941157 @default.
- W2005959147 creator A5076940881 @default.
- W2005959147 creator A5081771204 @default.
- W2005959147 creator A5087204284 @default.
- W2005959147 creator A5088798513 @default.
- W2005959147 date "2006-08-18" @default.
- W2005959147 modified "2023-10-18" @default.
- W2005959147 title "Genome‐wide screening of dioxin‐responsive genes in fetal brain: bioinformatic and experimental approaches" @default.
- W2005959147 cites W1527927437 @default.
- W2005959147 cites W1600605923 @default.
- W2005959147 cites W1858268805 @default.
- W2005959147 cites W1898862743 @default.
- W2005959147 cites W1953341270 @default.
- W2005959147 cites W1986234964 @default.
- W2005959147 cites W1987237342 @default.
- W2005959147 cites W1991612212 @default.
- W2005959147 cites W1994712659 @default.
- W2005959147 cites W1995551499 @default.
- W2005959147 cites W1995614751 @default.
- W2005959147 cites W1996423252 @default.
- W2005959147 cites W1998364073 @default.
- W2005959147 cites W1998413580 @default.
- W2005959147 cites W2004151275 @default.
- W2005959147 cites W2008083733 @default.
- W2005959147 cites W2009896818 @default.
- W2005959147 cites W2017997169 @default.
- W2005959147 cites W2021582762 @default.
- W2005959147 cites W2021818481 @default.
- W2005959147 cites W2022986290 @default.
- W2005959147 cites W2024584876 @default.
- W2005959147 cites W2033198979 @default.
- W2005959147 cites W2033284246 @default.
- W2005959147 cites W2034831859 @default.
- W2005959147 cites W2036904490 @default.
- W2005959147 cites W2045931107 @default.
- W2005959147 cites W2059382320 @default.
- W2005959147 cites W2073783949 @default.
- W2005959147 cites W2075006146 @default.
- W2005959147 cites W2075757290 @default.
- W2005959147 cites W2076569763 @default.
- W2005959147 cites W2079598692 @default.
- W2005959147 cites W2080862336 @default.
- W2005959147 cites W2083848894 @default.
- W2005959147 cites W2084748297 @default.
- W2005959147 cites W2090939833 @default.
- W2005959147 cites W2103017472 @default.
- W2005959147 cites W2120920194 @default.
- W2005959147 cites W2125507233 @default.
- W2005959147 cites W2131548572 @default.
- W2005959147 cites W2136145671 @default.
- W2005959147 cites W2137365670 @default.
- W2005959147 cites W2137986897 @default.
- W2005959147 cites W2139703939 @default.
- W2005959147 cites W2152273843 @default.
- W2005959147 cites W2160619422 @default.
- W2005959147 cites W2160697532 @default.
- W2005959147 cites W2163212976 @default.
- W2005959147 cites W2168717927 @default.
- W2005959147 cites W2168783124 @default.
- W2005959147 cites W2170989872 @default.
- W2005959147 cites W4229880569 @default.
- W2005959147 cites W4237781946 @default.
- W2005959147 doi "https://doi.org/10.1111/j.1741-4520.2006.00116.x" @default.
- W2005959147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16922920" @default.
- W2005959147 hasPublicationYear "2006" @default.
- W2005959147 type Work @default.
- W2005959147 sameAs 2005959147 @default.
- W2005959147 citedByCount "10" @default.
- W2005959147 countsByYear W20059591472014 @default.
- W2005959147 countsByYear W20059591472016 @default.
- W2005959147 countsByYear W20059591472017 @default.
- W2005959147 countsByYear W20059591472020 @default.
- W2005959147 countsByYear W20059591472022 @default.
- W2005959147 crossrefType "journal-article" @default.
- W2005959147 hasAuthorship W2005959147A5015575713 @default.
- W2005959147 hasAuthorship W2005959147A5026657616 @default.
- W2005959147 hasAuthorship W2005959147A5031252181 @default.
- W2005959147 hasAuthorship W2005959147A5063839512 @default.
- W2005959147 hasAuthorship W2005959147A5069941157 @default.
- W2005959147 hasAuthorship W2005959147A5076940881 @default.
- W2005959147 hasAuthorship W2005959147A5081771204 @default.
- W2005959147 hasAuthorship W2005959147A5087204284 @default.
- W2005959147 hasAuthorship W2005959147A5088798513 @default.
- W2005959147 hasConcept C101762097 @default.
- W2005959147 hasConcept C104317684 @default.
- W2005959147 hasConcept C132376346 @default.
- W2005959147 hasConcept C138885662 @default.
- W2005959147 hasConcept C141231307 @default.
- W2005959147 hasConcept C150194340 @default.
- W2005959147 hasConcept C179926584 @default.
- W2005959147 hasConcept C186836561 @default.
- W2005959147 hasConcept C30503417 @default.