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• W2005962017 abstract "Rationale: Identification of the subpopulation especially susceptible to the adverse effects of second-hand smoke exposure (SHS) would be useful for preventive actions and interventions.Objectives: To investigate whether asthmatic heredity indicates susceptibility to the effects of SHS on the risk of adult-onset asthma.Methods: A population-based incident case–control study of clinically defined adult-onset asthma and randomly drawn control subjects (adults 21–63 yr old) from a geographically defined area in South Finland. After excluding current and ex-smokers there were 226 cases and 450 disease-free control subjects.Measurements and Main Results: Our outcome measure was new adult-onset asthma. Parental asthma and recent SHS had a synergistic effect on the risk of asthma, the adjusted odds ratio being 1.97 (95% confidence interval, 1.12–3.45) for SHS; 2.64 (1.65–4.24) for parental asthma; and 12.69 (3.44–46.91) for their joint effect (relative excess risk due interaction, 9.08 [−0.22 to 43.18]). Synergistic effect followed a dose-dependent pattern with both recent and cumulative SHS exposures, with relative excess risk due interaction for parental asthma and over 100 SHS cigarette-years of 6.17 (0.57–19.16).Conclusions: This is the first study showing that individuals with asthmatic heredity have a considerably increased risk of adult-onset asthma when exposed to SHS. SHS exposure has dose-dependent synergism with family history of asthma, the joint effect being stronger with higher exposure levels. Avoiding SHS could be an important preventive measure for reducing the risk of adult-onset asthma among those with asthmatic heredity. Asking about family history of asthma is a useful tool for identifying these susceptible individuals in clinical and preventive settings." @default.
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• W2005962017 date "2013-10-01" @default.
• W2005962017 modified "2023-09-30" @default.
• W2005962017 title "The Synergistic Effect of Heredity and Exposure to Second-Hand Smoke on Adult-Onset Asthma" @default.
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• W2005962017 doi "https://doi.org/10.1164/rccm.201304-0773oc" @default.
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