FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005962512> ?p ?o ?g. }

• W2005962512 endingPage "676" @default.
• W2005962512 startingPage "670" @default.
• W2005962512 abstract "Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphism for the effects of omeprazole on intragastric pH and plasma gastrin concentrations has been investigated.Twenty-five white patients were genotyped for CYP2C19 by allele-specific polymerase chain reaction amplification, and their Helicobacter pylori status was assessed by serology and with immunoblot analysis. Intragastric pH was monitored over 24 hours, and meal-stimulated plasma gastrin concentration was measured over 4 hours (AUC 4h) before (day 0) and during (day 8) treatment with 20 mg omeprazole once daily.Eleven patients were homozygous for the wild-type allele (wt/wt), 12 were heterozygous EMs (wt/mut), and 2 were PMs (mut/mut). Median (95% confidence interval) 24-hour intragastric pH in the heterozygous EM group was 5.5 (range, 5.1-5. 9) compared with 3.1 (range, 2.7-3.6) in homozygous EMs (P < 0.0001) at day 8. The percentage of time with intragastric pH > 4 at day 8 was significantly higher in the wt/mut than wt/wt group (72.4% vs. 37.1%; P < 0.0001). H. pylori status had less influence than CYP2C19 on intragastric acidity. Omeprazole treatment increased meal-stimulated plasma gastrin concentrations from day 0 to day 8 in the homozygous EMs and heterozygous EMs by 16% (NS) and 157% (P = 0. 002), respectively. In heterozygous EMs, the gastrin increase was more pronounced in the H. pylori-positive group (226%) than H. pylori-negative group (80%; P = 0.02).The effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism in patients with acid-related disorders." @default.
• W2005962512 created "2016-06-24" @default.
• W2005962512 creator A5001100678 @default.
• W2005962512 creator A5013627969 @default.
• W2005962512 creator A5031338295 @default.
• W2005962512 creator A5038555087 @default.
• W2005962512 creator A5081937972 @default.
• W2005962512 date "2000-09-01" @default.
• W2005962512 modified "2023-10-18" @default.
• W2005962512 title "Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism" @default.
• W2005962512 cites W1550666015 @default.
• W2005962512 cites W1881509706 @default.
• W2005962512 cites W1970636233 @default.
• W2005962512 cites W1971221969 @default.
• W2005962512 cites W1973313159 @default.
• W2005962512 cites W1973615600 @default.
• W2005962512 cites W1979392961 @default.
• W2005962512 cites W1981202966 @default.
• W2005962512 cites W1982805851 @default.
• W2005962512 cites W1983300063 @default.
• W2005962512 cites W1991626196 @default.
• W2005962512 cites W1995037065 @default.
• W2005962512 cites W1997675866 @default.
• W2005962512 cites W2005670414 @default.
• W2005962512 cites W2007711753 @default.
• W2005962512 cites W2020075696 @default.
• W2005962512 cites W2023875720 @default.
• W2005962512 cites W2027507003 @default.
• W2005962512 cites W2028912886 @default.
• W2005962512 cites W2049377642 @default.
• W2005962512 cites W2050282552 @default.
• W2005962512 cites W2069444177 @default.
• W2005962512 cites W2074165913 @default.
• W2005962512 cites W2076694998 @default.
• W2005962512 cites W2086422928 @default.
• W2005962512 cites W2087437997 @default.
• W2005962512 cites W2093678250 @default.
• W2005962512 cites W2094212245 @default.
• W2005962512 cites W2103671496 @default.
• W2005962512 cites W2111073764 @default.
• W2005962512 cites W2118548680 @default.
• W2005962512 cites W2121761101 @default.
• W2005962512 cites W2146200920 @default.
• W2005962512 cites W2168234648 @default.
• W2005962512 cites W2170709016 @default.
• W2005962512 cites W2415409947 @default.
• W2005962512 cites W74755816 @default.
• W2005962512 doi "https://doi.org/10.1053/gast.2000.16515" @default.
• W2005962512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10982760" @default.
• W2005962512 hasPublicationYear "2000" @default.
• W2005962512 type Work @default.
• W2005962512 sameAs 2005962512 @default.
• W2005962512 citedByCount "68" @default.
• W2005962512 countsByYear W20059625122014 @default.
• W2005962512 countsByYear W20059625122015 @default.
• W2005962512 countsByYear W20059625122016 @default.
• W2005962512 countsByYear W20059625122017 @default.
• W2005962512 countsByYear W20059625122018 @default.
• W2005962512 countsByYear W20059625122019 @default.
• W2005962512 countsByYear W20059625122020 @default.
• W2005962512 countsByYear W20059625122021 @default.
• W2005962512 countsByYear W20059625122023 @default.
• W2005962512 crossrefType "journal-article" @default.
• W2005962512 hasAuthorship W2005962512A5001100678 @default.
• W2005962512 hasAuthorship W2005962512A5013627969 @default.
• W2005962512 hasAuthorship W2005962512A5031338295 @default.
• W2005962512 hasAuthorship W2005962512A5038555087 @default.
• W2005962512 hasAuthorship W2005962512A5081937972 @default.
• W2005962512 hasConcept C104317684 @default.
• W2005962512 hasConcept C126322002 @default.
• W2005962512 hasConcept C134018914 @default.
• W2005962512 hasConcept C140840227 @default.
• W2005962512 hasConcept C180754005 @default.
• W2005962512 hasConcept C185592680 @default.
• W2005962512 hasConcept C2776409635 @default.
• W2005962512 hasConcept C2776986829 @default.
• W2005962512 hasConcept C2777498785 @default.
• W2005962512 hasConcept C2778345441 @default.
• W2005962512 hasConcept C49039625 @default.
• W2005962512 hasConcept C526171541 @default.
• W2005962512 hasConcept C55493867 @default.
• W2005962512 hasConcept C62231903 @default.
• W2005962512 hasConcept C71924100 @default.
• W2005962512 hasConceptScore W2005962512C104317684 @default.
• W2005962512 hasConceptScore W2005962512C126322002 @default.
• W2005962512 hasConceptScore W2005962512C134018914 @default.
• W2005962512 hasConceptScore W2005962512C140840227 @default.
• W2005962512 hasConceptScore W2005962512C180754005 @default.
• W2005962512 hasConceptScore W2005962512C185592680 @default.
• W2005962512 hasConceptScore W2005962512C2776409635 @default.
• W2005962512 hasConceptScore W2005962512C2776986829 @default.
• W2005962512 hasConceptScore W2005962512C2777498785 @default.
• W2005962512 hasConceptScore W2005962512C2778345441 @default.
• W2005962512 hasConceptScore W2005962512C49039625 @default.
• W2005962512 hasConceptScore W2005962512C526171541 @default.
• W2005962512 hasConceptScore W2005962512C55493867 @default.
• W2005962512 hasConceptScore W2005962512C62231903 @default.
• W2005962512 hasConceptScore W2005962512C71924100 @default.

• next