FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005962936> ?p ?o ?g. }

• W2005962936 endingPage "594" @default.
• W2005962936 startingPage "591" @default.
• W2005962936 abstract "Gulf War syndrome (GWS) is a perplexing multi-symptom condition comprising a constellation of signs and symptoms consistently described in the literature. These include muscle fatigue and tiredness, malaise, myalgia, impaired cognition, ataxia, diarrhoea, bladder dysfunction, sweating disturbances, headaches, fever, arthralgia, skin rashes, and gastrointestinal and sleep disturbances. Excessive chemical sensitivity and odour intolerance is reported. Epidemiological analysis suggests association with pyridostigmine bromide (PB) use as nerve gas prophylaxis, insect repellent, certain vaccination regimes, a variety of possible chemical exposures and physical and psychological stress. Pituitary adenylate cyclase-activating polypeptide (PACAP), calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) are potent vasoactive (vasodilatory) neuropeptides (VNs) having pleiotropic functions as immunomodulators, neuroregulators and hormones. VNs also have neurotrophic and anti-apoptotic roles. VNs act on G protein-coupled receptors (GPCRs) to activate adenylate cyclase, an important step in cyclic AMP metabolism. Autoimmune dysfunction of these VNs or their receptors is postulated to give rise to fatigue-related conditions such as chronic fatigue syndrome (CFS). Complex mechanisms involving heat shock proteins (hsps) and cytosine-guanine dinucleotide (CpG) DNA fragments may also be associated with autoimmunity to VNs or their GPCRs in contributing to fatigue-related conditions. Dysfunction of certain VNs may be the missing link in explaining the nebulous nexus between PB and GWS. This paper explores a possible link between exposures to PB and other chemical, physical and psychological stressors in producing a fatigue-related illness possibly related to autoimmune dysfunction of certain VNs. Treatment options involving restoration of VN function are considered in the context of analogues with other neurotransmitter fatigue-related conditions such as myasthenia gravis (MG). While evidence associating these conditions is thin, vasoactive neuropeptide neurotransmitters of the VIP/PACAP family have acetylcholine co-transmission functions via specific GPCRs. Autoimmune reactions to these receptors may have parallels with muscarinic (e.g., Sjogren’s syndrome) and nicotinic (e.g., MG) acetylcholine neurotransmission. Hence theoretically, treatment options such as thymectomy, corticosteroids, plasma exchange, anti-idiotype antibodies and receptor genomic expression reactivation/suppression may be considered. Paradoxically pyridostigmine may prove to have a role in therapy although VN treatment/replacement may be associated with tachyphylaxis." @default.
• W2005962936 created "2016-06-24" @default.
• W2005962936 creator A5049783398 @default.
• W2005962936 date "2005-01-01" @default.
• W2005962936 modified "2023-10-15" @default.
• W2005962936 title "Do vasoactive neuropeptide autoimmune disorders explain pyridostigmine’s association with Gulf War syndrome?" @default.
• W2005962936 cites W1511707790 @default.
• W2005962936 cites W1548770619 @default.
• W2005962936 cites W1964065006 @default.
• W2005962936 cites W1973100947 @default.
• W2005962936 cites W1974311764 @default.
• W2005962936 cites W1974616331 @default.
• W2005962936 cites W1974954925 @default.
• W2005962936 cites W1993926163 @default.
• W2005962936 cites W1993961583 @default.
• W2005962936 cites W2002955404 @default.
• W2005962936 cites W2003817165 @default.
• W2005962936 cites W2011200122 @default.
• W2005962936 cites W2022858836 @default.
• W2005962936 cites W2036167046 @default.
• W2005962936 cites W2073680414 @default.
• W2005962936 cites W2076990291 @default.
• W2005962936 cites W2084517994 @default.
• W2005962936 cites W2103853299 @default.
• W2005962936 cites W2121789999 @default.
• W2005962936 cites W2131888178 @default.
• W2005962936 cites W2136512980 @default.
• W2005962936 cites W2167115215 @default.
• W2005962936 cites W2342054781 @default.
• W2005962936 cites W4230000569 @default.
• W2005962936 cites W4242692261 @default.
• W2005962936 doi "https://doi.org/10.1016/j.mehy.2005.02.036" @default.
• W2005962936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16004938" @default.
• W2005962936 hasPublicationYear "2005" @default.
• W2005962936 type Work @default.
• W2005962936 sameAs 2005962936 @default.
• W2005962936 citedByCount "7" @default.
• W2005962936 countsByYear W20059629362012 @default.
• W2005962936 countsByYear W20059629362013 @default.
• W2005962936 countsByYear W20059629362014 @default.
• W2005962936 crossrefType "journal-article" @default.
• W2005962936 hasAuthorship W2005962936A5049783398 @default.
• W2005962936 hasConcept C118303440 @default.
• W2005962936 hasConcept C126322002 @default.
• W2005962936 hasConcept C134018914 @default.
• W2005962936 hasConcept C170493617 @default.
• W2005962936 hasConcept C203014093 @default.
• W2005962936 hasConcept C2778105408 @default.
• W2005962936 hasConcept C2779680196 @default.
• W2005962936 hasConcept C2779901103 @default.
• W2005962936 hasConcept C2780130043 @default.
• W2005962936 hasConcept C71924100 @default.
• W2005962936 hasConcept C8330315 @default.
• W2005962936 hasConcept C8891405 @default.
• W2005962936 hasConceptScore W2005962936C118303440 @default.
• W2005962936 hasConceptScore W2005962936C126322002 @default.
• W2005962936 hasConceptScore W2005962936C134018914 @default.
• W2005962936 hasConceptScore W2005962936C170493617 @default.
• W2005962936 hasConceptScore W2005962936C203014093 @default.
• W2005962936 hasConceptScore W2005962936C2778105408 @default.
• W2005962936 hasConceptScore W2005962936C2779680196 @default.
• W2005962936 hasConceptScore W2005962936C2779901103 @default.
• W2005962936 hasConceptScore W2005962936C2780130043 @default.
• W2005962936 hasConceptScore W2005962936C71924100 @default.
• W2005962936 hasConceptScore W2005962936C8330315 @default.
• W2005962936 hasConceptScore W2005962936C8891405 @default.
• W2005962936 hasIssue "3" @default.
• W2005962936 hasLocation W20059629361 @default.
• W2005962936 hasLocation W20059629362 @default.
• W2005962936 hasOpenAccess W2005962936 @default.
• W2005962936 hasPrimaryLocation W20059629361 @default.
• W2005962936 hasRelatedWork W1968961493 @default.
• W2005962936 hasRelatedWork W2009067699 @default.
• W2005962936 hasRelatedWork W2016220527 @default.
• W2005962936 hasRelatedWork W2037121844 @default.
• W2005962936 hasRelatedWork W2060793395 @default.
• W2005962936 hasRelatedWork W2074026543 @default.
• W2005962936 hasRelatedWork W2077005037 @default.
• W2005962936 hasRelatedWork W2143153962 @default.
• W2005962936 hasRelatedWork W2417279273 @default.
• W2005962936 hasRelatedWork W630204683 @default.
• W2005962936 hasVolume "65" @default.
• W2005962936 isParatext "false" @default.
• W2005962936 isRetracted "false" @default.
• W2005962936 magId "2005962936" @default.
• W2005962936 workType "article" @default.