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- W2005965887 abstract "The effect of the oral administration of saliva-parotin-A to rats was studied in comparing with that of subcutaneous injection of the substance. Sialoadenectomized and sham operated male rats of Donryu strain (28 days old) were orally administered with 0.6 and 3.0mg per 100g of body weight of saliva-parotin-A for 3 weeks and subcutaneously with 0.03mg per 100g of body weight. The morphologicaleffects upon tibial epiphysis and adrenal cortex were examined. The reduction of the width of cartilage plate and atrophic pattern of primary spongiosa were found in the tibial epiphysis in control non-injected rats 3 weeks after the sialoadenectomy. Subcutaneous injection of saliva-parotin-A retarded the subsequent involution to the sialoadenectomy, and the oral administration of salivaparotin-A also could retard the epiphyseal involution with the dose of 3mg per 100g of body weight, corresponding the 100 times dosage to the subcutaneous injection. No effect on the involution was recognized in rats with the oral administration of 0.6mg. In the adrenal cortex, a kind of stressful picture was observed after the sialoadenectomy or subcutaneous injection of saliva-parotin-A. In the rats received 3mg of saliva-parotin-A orally, however, such changes were neither observed in adrenal of the sialoadenectomized rats nor in the sham operated ones." @default.
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- W2005965887 date "1965-01-01" @default.
- W2005965887 modified "2023-10-02" @default.
- W2005965887 title "STUDIES ON THE ORAL ADMINISTRATION OF SALIVAPAROTIN-A II. EFFECTS ON THE EPIPHYSEAL GROWTH OF TIBIA IN RATS" @default.
- W2005965887 doi "https://doi.org/10.1507/endocrj1954.12.305" @default.
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