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• W2005966470 abstract "Phagocytosis through Fcγ receptor (FcγR) or complement receptor 3 (CR) requires Arp2/3 complex-mediated actin polymerization, although each receptor uses a distinct signaling pathway [1Kaplan G. Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages.Scand. J. Immunol. 1977; 6: 797-807Crossref PubMed Scopus (163) Google Scholar]. Rac and Cdc42 are required for actin and Arp2/3 complex recruitment during FcγR phagocytosis, while Rho controls actin assembly at CR phagosomes [2Caron E. Hall A. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases.Science. 1998; 282: 1717-1721Crossref PubMed Scopus (768) Google Scholar, 3May R.C. Caron E. Hall A. Machesky L.M. Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3.Nat. Cell Biol. 2000; 2: 246-248Crossref PubMed Scopus (255) Google Scholar]. To better understand the role of Rho in CR phagocytosis, we tested the idea that a known target of Rho, Rho-kinase (ROK), might control phagocytic cup formation and/or engulfment of particles. Inhibitors of ROK (dominant-negative ROK and Y-27632) and of the downstream target of ROK, myosin-II (ML7, BDM, and dominant-negative myosin-II), were used to test this idea. We found that inhibition of the Rho → ROK → myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment. FcγR-mediated phagocytosis, in contrast, was independent of Rho or ROK activity and was only dependent on myosin-II for particle internalization, not for actin cup formation. While myosins have been previously implicated in FcγR phagocytosis [4Swanson J.A. Johnson M.T. Beningo K. Post P. Mooseker M. Araki N. A contractile activity that closes phagosomes in macrophages.J. Cell Sci. 1999; 112: 307-316Crossref PubMed Google Scholar, 5Mansfield P.J. Shayman J.A. Boxer L.A. Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase.Blood. 2000; 95: 2407-2412Crossref PubMed Google Scholar, 6Diakonova M. Bokoch G. Swanson J.A. Dynamics of cytoskeletal proteins during Fcγ receptor-mediated phagocytosis in macrophages.Mol. Biol. Cell. 2002; 13: 402-411Crossref PubMed Scopus (118) Google Scholar], to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis." @default.
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• W2005966470 date "2002-08-01" @default.
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• W2005966470 title "Rho-Kinase and Myosin-II Control Phagocytic Cup Formation during CR, but Not FcγR, Phagocytosis" @default.
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• W2005966470 doi "https://doi.org/10.1016/s0960-9822(02)01069-2" @default.
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