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- W2005977280 abstract "RATIONALE: Individuals with increased birth order have a smaller risk of allergy (birth order effect). However, the significance of the effect may differ by allergic disease. The purpose of the study was to compare the significance of the birth order effect on the prevalence of specific allergic diseases (bronchial asthma (BA), atopic dermatitis (AD), allergic rhinitis (AR), allergic conjunctivitis (AC), and food allergy (FA)) among school children. METHODS: A questionnaire survey dealing with the prevalence of allergic diseases was administered to the parents of more than 13,000 schoolchildren aged 7 to 15 years. Based on the data, the prevalence of each allergic disease was compared according to birth order (1st, 2nd, and later). Multiple regression analysis was performed to test the significance of the differences. RESULTS: There was no significant difference in the prevalence of BA or AD according to birth order. The prevalence of AR, AC, and FA decreased significantly as birth order increased. The prevalence of FA among those with 1st, 2nd and later birth order was 4.0%, 3.5% and 2.6%, respectively (p=0.01). With respect to symptoms in infancy, the prevalence of wheeze increased significantly and of food allergy decreased significantly as birth order increased. CONCLUSIONS: We observed the disease specificity of the birth order effect on allergy among schoolchildren. The present data are the first to show a birth order effect on food allergy. The fact that the effect was also observed for food allergy in infancy suggests its prenatal origin." @default.
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- W2005977280 date "2011-02-01" @default.
- W2005977280 modified "2023-10-16" @default.
- W2005977280 title "Birth Order Effect on the Prevalence of Childhood Allergy: Comparisons among Different Allergic Diseases" @default.
- W2005977280 doi "https://doi.org/10.1016/j.jaci.2010.12.552" @default.
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