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• W2005980016 abstract "Synaptic vesicles isolated from the caudate nucleus of the pig were incubated with labelled (±)-, (−)-noradrenaline, dopamine, tyramine, (±)-octopamine, (+)-amphetamine or β-phenylethyl-amine in the presence or in the absence of ATP-Mg2+. After incubation the vesicles were separated by filtration through membrane filters. In the absence of ATP-Mg2+ the phenethylamines used were taken up at different rates showing direct proportionality to the amine concentration in the incubation medium. The rate of uptake of the undissociated amines (at pH 7.4) depended on their lipophilic character. ATP-Mg2+ enhanced the uptake of (±)-, (−)-noradrenaline, dopamine, tyramine and (±)-octopamine; the uptake of amphetamine and β-phenylethylamine was not influenced. The ATP-Mg2+ dependent uptake was saturable and obeyed Michaelis-Menten kinetics. ATP-Mg2+ enhanced the uptake of compounds, which possessed at least one OH-group at the benzene ring. Amines with one OH-group in para-position or an additional one to that of the benzene ring and no OH-group in the side-chain showed similar affinities. OH-substitution in β-position of the side-chain decreased the affinity. The affinity to the transport system increased with increasing lipophilic character of the amine." @default.
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• W2005980016 date "1981-07-01" @default.
• W2005980016 modified "2023-09-23" @default.
• W2005980016 title "Physico-chemical properties of phenethylamines and their uptake into synaptic vesicles of the caudate nucleus" @default.
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• W2005980016 doi "https://doi.org/10.1016/0006-2952(81)90006-x" @default.
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