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• W2005986108 abstract "The aim of this study was to use flow cytometry to analyze the expression of cell cycle-regulating elementswith low and high proliferative signatures in patients with malignant diseases.Cyclin D, E, A, and B, and cyclin-dependent kinase inhibitor (CDKI) p16 and p21 levels weremeasured via flow cytometry in patients with chronic myeloid leukemia (CML) (n = 16) and multiple myeloma (MM)(n = 13), and in controls (n = 15).The distributions of the cell cycle S phase were 10, 63%, 6, 72% and 3, 59%; for CML, MM and controlpatients, respectively. Among all the cyclins expressed during the S phase, cyclin D expression was the lowest in the CMLpatients. Distribution of cyclins and CDKIs during the G2/M phase was similar in the MM and control groups, whereascyclin expression was similar during all 3 phases in the MM and CML groups.Elevated cyclin expression during cell cycle phases in the CML and MM patients was not associatedwith elevated CDKI expression. This finding may increase our understanding of the mechanisms involved in theetiopathogenesis of hematological malignancy.Amaç: Bu çalışmanın amacı, yüksek ve düşük proliferasyon hızına sahip malign hastalıklarda, hücre siklusunu düzenleyen faktörlerin flow sitometrik olarak analiz edilmesidir. Gereç ve Yöntemler: Kronik miyelositer lösemi (KML) (n=16), Multipl Miyelom (MM) (n=13) ve kontrol (n=15) olgularında siklin D, E, A, B ve siklin bağımlı kinaz inhibitörü (SBKİ) p16, p21 düzeyleri akımsitometrik yöntemle ölçülmüş ve değerlendirilmiştir. Bulgular: KML, MM ve kontrol olgularındaki S evresi dağılımı sırasıyla % 10, 63; % 6, 72 ve % 3, 59 olarak saptanmıştır. KML grubunda siklin D ekspresyonu, S evresindeki diğer siklinlere göre en düşük düzeyde bulunmuştur. G2/M evresinde, MM ve kontrol gruplarındaki siklin ve SBKİ düzeyleri birbirleriyle benzer saptanırken, MM ve KML gruplarının her üç evresindeki siklin ekspresyonları ise paralel bulunmuştur.Sonuç: Kontrol grubuyla karşılaştırıldığında hasta gruplarında, siklin ekspresyonlarının artışına SBKİ düzeylerinin artışının eşlik etmediği saptanmıştır. Bu bulgu, belki de hematolojik malign hastalıkların etyopatogenezinin açıklanmasına katkıda bulunabilecektir." @default.
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• W2005986108 date "2012-01-01" @default.
• W2005986108 modified "2023-10-11" @default.
• W2005986108 title "Flowcytometric evaluation of cell cycle regulators (cyclins and cyclin dependent kinase inhibitors) expressed on bone marrow cells of patients with chronic myelogenous leukemia and multiple myeloma" @default.
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• W2005986108 doi "https://doi.org/10.5505/tjh.2012.33602" @default.
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