Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005987432> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2005987432 endingPage "63" @default.
- W2005987432 startingPage "62" @default.
- W2005987432 abstract "Novel lipophilic platinum(II) complexes (LSPt-1–3), containing 3,5-diisopropylsalicylate (DIPS) as a leaving group and 2NH3 or 1R,2R-diaminocyclohexane or (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane as the carrier, have been synthesized, characterized and evaluated in vitro and in vivo. The octanol/water distribution coefficient of the complexes has also been measured. The results showed that the complexes achieved a typical square planar and the octanol/water distribution coefficient log P was 4.27, 4.37 and 4.31. The complexes were tested by SRB method to be more cytotoxic than Carboplatin, Oxaliplatin and Eptaplatin against 3AO, A549, NCI-H460 and SGC-7901 human cancer cell lines. Among complexes, LSPt-2 was much more effective than Carboplatin and Oxaliplatin in treating the NCI-H460 non-small-cell lung tumor-bearing mice. Its optimal activity was 38.8% (T/C) at a dose of 30 mg/kg following i.p. administration. LD50 for the complex was found to be 230.9 mg/kg. LSPt-2 exhibited great anticancer activity, good lipophilic ability and low toxicity and therefore, it is a promising candidate for effective and stable pharmaceutical liposomal platinum anticancer drug." @default.
- W2005987432 created "2016-06-24" @default.
- W2005987432 creator A5000467161 @default.
- W2005987432 creator A5001577724 @default.
- W2005987432 creator A5002125393 @default.
- W2005987432 creator A5016945305 @default.
- W2005987432 creator A5050786207 @default.
- W2005987432 creator A5065416842 @default.
- W2005987432 creator A5083041938 @default.
- W2005987432 date "2010-06-01" @default.
- W2005987432 modified "2023-10-12" @default.
- W2005987432 title "238 The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin" @default.
- W2005987432 doi "https://doi.org/10.1016/s1359-6349(10)71045-4" @default.
- W2005987432 hasPublicationYear "2010" @default.
- W2005987432 type Work @default.
- W2005987432 sameAs 2005987432 @default.
- W2005987432 citedByCount "1" @default.
- W2005987432 countsByYear W20059874322015 @default.
- W2005987432 crossrefType "journal-article" @default.
- W2005987432 hasAuthorship W2005987432A5000467161 @default.
- W2005987432 hasAuthorship W2005987432A5001577724 @default.
- W2005987432 hasAuthorship W2005987432A5002125393 @default.
- W2005987432 hasAuthorship W2005987432A5016945305 @default.
- W2005987432 hasAuthorship W2005987432A5050786207 @default.
- W2005987432 hasAuthorship W2005987432A5065416842 @default.
- W2005987432 hasAuthorship W2005987432A5083041938 @default.
- W2005987432 hasConcept C109316439 @default.
- W2005987432 hasConcept C121608353 @default.
- W2005987432 hasConcept C126322002 @default.
- W2005987432 hasConcept C150903083 @default.
- W2005987432 hasConcept C178790620 @default.
- W2005987432 hasConcept C185592680 @default.
- W2005987432 hasConcept C202751555 @default.
- W2005987432 hasConcept C207001950 @default.
- W2005987432 hasConcept C2776694085 @default.
- W2005987432 hasConcept C2777752497 @default.
- W2005987432 hasConcept C2778239845 @default.
- W2005987432 hasConcept C2780962732 @default.
- W2005987432 hasConcept C2781303535 @default.
- W2005987432 hasConcept C2781451048 @default.
- W2005987432 hasConcept C29730261 @default.
- W2005987432 hasConcept C526805850 @default.
- W2005987432 hasConcept C55493867 @default.
- W2005987432 hasConcept C71240020 @default.
- W2005987432 hasConcept C71924100 @default.
- W2005987432 hasConcept C86803240 @default.
- W2005987432 hasConcept C98274493 @default.
- W2005987432 hasConceptScore W2005987432C109316439 @default.
- W2005987432 hasConceptScore W2005987432C121608353 @default.
- W2005987432 hasConceptScore W2005987432C126322002 @default.
- W2005987432 hasConceptScore W2005987432C150903083 @default.
- W2005987432 hasConceptScore W2005987432C178790620 @default.
- W2005987432 hasConceptScore W2005987432C185592680 @default.
- W2005987432 hasConceptScore W2005987432C202751555 @default.
- W2005987432 hasConceptScore W2005987432C207001950 @default.
- W2005987432 hasConceptScore W2005987432C2776694085 @default.
- W2005987432 hasConceptScore W2005987432C2777752497 @default.
- W2005987432 hasConceptScore W2005987432C2778239845 @default.
- W2005987432 hasConceptScore W2005987432C2780962732 @default.
- W2005987432 hasConceptScore W2005987432C2781303535 @default.
- W2005987432 hasConceptScore W2005987432C2781451048 @default.
- W2005987432 hasConceptScore W2005987432C29730261 @default.
- W2005987432 hasConceptScore W2005987432C526805850 @default.
- W2005987432 hasConceptScore W2005987432C55493867 @default.
- W2005987432 hasConceptScore W2005987432C71240020 @default.
- W2005987432 hasConceptScore W2005987432C71924100 @default.
- W2005987432 hasConceptScore W2005987432C86803240 @default.
- W2005987432 hasConceptScore W2005987432C98274493 @default.
- W2005987432 hasIssue "5" @default.
- W2005987432 hasLocation W20059874321 @default.
- W2005987432 hasOpenAccess W2005987432 @default.
- W2005987432 hasPrimaryLocation W20059874321 @default.
- W2005987432 hasRelatedWork W1885021629 @default.
- W2005987432 hasRelatedWork W1982610991 @default.
- W2005987432 hasRelatedWork W1989809643 @default.
- W2005987432 hasRelatedWork W2122023026 @default.
- W2005987432 hasRelatedWork W2374639958 @default.
- W2005987432 hasRelatedWork W2416964709 @default.
- W2005987432 hasRelatedWork W2525456170 @default.
- W2005987432 hasRelatedWork W3000011530 @default.
- W2005987432 hasRelatedWork W4361254497 @default.
- W2005987432 hasRelatedWork W4361254623 @default.
- W2005987432 hasVolume "8" @default.
- W2005987432 isParatext "false" @default.
- W2005987432 isRetracted "false" @default.
- W2005987432 magId "2005987432" @default.
- W2005987432 workType "article" @default.