FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005989788> ?p ?o ?g. }

• W2005989788 endingPage "506" @default.
• W2005989788 startingPage "506" @default.
• W2005989788 abstract "To compare the effectiveness of immunization with naked DNA corresponding to the genes encoding five HSV-1 glycoproteins, gB, gC, gD, gE, and gI (5gP DNA), with immunization with the five glycoproteins (5gP protein). Also, to compare immunization of 5gP protein in Montanide ISA 720 (SEPPIC, Paris, France), an adjuvant recently approved for use in humans, with immunization of 5gP protein in Freund's adjuvant.BALB/c mice were vaccinated with 5gP DNA or 5gP protein emulsified in ISA 720 or Freund's adjuvant. Neutralizing antibody titers were determined by plaque-reduction assays. IL-2, -4, and -12 and IFN-gamma levels were determined by ELISA after in vitro stimulation of spleen cells. After ocular challenge with 2 x 10(5) plaque-forming units [pfu] per eye of HSV-1 strain McKrae, virus replication in the eye, survival, blepharitis, corneal scarring, and latency were determined.Neutralizing antibody titers (approximately 1:800-1:1200), corneal scarring (trace) and survival (100%) were similar for all vaccine groups, including 5gP DNA. Compared with the other vaccine groups, the 5gP DNA group had less ocular virus replication, as judged both by maximum virus titer and time of viral clearance. ISA 720 appeared more effective than Freund's against ocular virus replication and eye disease. The 5gP DNA-vaccinated mice had less blepharitis and latency than any other group and had the highest levels of IL-12 and IFN-gamma. All vaccine groups had similar levels of IL-2.The 5gP DNA vaccine appeared to be more effective than the corresponding protein subunit vaccine, regardless of adjuvant. Emulsification of the 5gP protein in ISA 720 appeared to be more effective than emulsification in Freund's adjuvant." @default.
• W2005989788 created "2016-06-24" @default.
• W2005989788 creator A5038418623 @default.
• W2005989788 creator A5075884461 @default.
• W2005989788 creator A5089793053 @default.
• W2005989788 date "2004-02-01" @default.
• W2005989788 modified "2023-10-16" @default.
• W2005989788 title "Improved Protection from Primary Ocular HSV-1 Infection and Establishment of Latency Using Multigenic DNA Vaccines" @default.
• W2005989788 cites W146784447 @default.
• W2005989788 cites W1494955552 @default.
• W2005989788 cites W1540321365 @default.
• W2005989788 cites W154082721 @default.
• W2005989788 cites W1576313851 @default.
• W2005989788 cites W1601925808 @default.
• W2005989788 cites W1616749824 @default.
• W2005989788 cites W1675081787 @default.
• W2005989788 cites W173792208 @default.
• W2005989788 cites W1850794279 @default.
• W2005989788 cites W1966083353 @default.
• W2005989788 cites W1968809427 @default.
• W2005989788 cites W1969352328 @default.
• W2005989788 cites W197115685 @default.
• W2005989788 cites W1972832676 @default.
• W2005989788 cites W1977437107 @default.
• W2005989788 cites W1979514172 @default.
• W2005989788 cites W1979657237 @default.
• W2005989788 cites W1983364533 @default.
• W2005989788 cites W1983806918 @default.
• W2005989788 cites W1991464867 @default.
• W2005989788 cites W2004829503 @default.
• W2005989788 cites W2005132226 @default.
• W2005989788 cites W2005220504 @default.
• W2005989788 cites W2005770386 @default.
• W2005989788 cites W2010197375 @default.
• W2005989788 cites W2011072884 @default.
• W2005989788 cites W2019840235 @default.
• W2005989788 cites W2020356232 @default.
• W2005989788 cites W2021840830 @default.
• W2005989788 cites W2024056354 @default.
• W2005989788 cites W2025896394 @default.
• W2005989788 cites W2027765075 @default.
• W2005989788 cites W2029811971 @default.
• W2005989788 cites W2029836713 @default.
• W2005989788 cites W2031156476 @default.
• W2005989788 cites W2034736009 @default.
• W2005989788 cites W2037118263 @default.
• W2005989788 cites W2040457358 @default.
• W2005989788 cites W2041323254 @default.
• W2005989788 cites W2044194032 @default.
• W2005989788 cites W2044955470 @default.
• W2005989788 cites W2053801470 @default.
• W2005989788 cites W2056650797 @default.
• W2005989788 cites W2058444999 @default.
• W2005989788 cites W2061854007 @default.
• W2005989788 cites W2062520454 @default.
• W2005989788 cites W2069128835 @default.
• W2005989788 cites W2076026828 @default.
• W2005989788 cites W2080667413 @default.
• W2005989788 cites W2081488264 @default.
• W2005989788 cites W2084882265 @default.
• W2005989788 cites W2085540113 @default.
• W2005989788 cites W2087296395 @default.
• W2005989788 cites W2088198208 @default.
• W2005989788 cites W2090018727 @default.
• W2005989788 cites W2094383761 @default.
• W2005989788 cites W2095261470 @default.
• W2005989788 cites W2097755672 @default.
• W2005989788 cites W2098216175 @default.
• W2005989788 cites W2104439753 @default.
• W2005989788 cites W2106001308 @default.
• W2005989788 cites W2106538501 @default.
• W2005989788 cites W2110745776 @default.
• W2005989788 cites W2120024102 @default.
• W2005989788 cites W2125575601 @default.
• W2005989788 cites W2126559394 @default.
• W2005989788 cites W2131071261 @default.
• W2005989788 cites W2137681090 @default.
• W2005989788 cites W2143400181 @default.
• W2005989788 cites W2146011419 @default.
• W2005989788 cites W2151174052 @default.
• W2005989788 cites W2152510078 @default.
• W2005989788 cites W2153774223 @default.
• W2005989788 cites W2155851157 @default.
• W2005989788 cites W2156555210 @default.
• W2005989788 cites W2166941685 @default.
• W2005989788 cites W2172466148 @default.
• W2005989788 cites W2331858372 @default.
• W2005989788 cites W2410451629 @default.
• W2005989788 cites W2582398023 @default.
• W2005989788 cites W5786138 @default.
• W2005989788 doi "https://doi.org/10.1167/iovs.03-0828" @default.
• W2005989788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14744892" @default.
• W2005989788 hasPublicationYear "2004" @default.
• W2005989788 type Work @default.
• W2005989788 sameAs 2005989788 @default.
• W2005989788 citedByCount "35" @default.
• W2005989788 countsByYear W20059897882012 @default.
• W2005989788 countsByYear W20059897882013 @default.

• next