FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005992918> ?p ?o ?g. }

• W2005992918 endingPage "196" @default.
• W2005992918 startingPage "187" @default.
• W2005992918 abstract "Taste receptor cells are replaced throughout life, accompanied by continuing synaptogenesis between newly formed taste cells and first-order gustatory fibers. The neural cell adhesion molecule (NCAM) is expressed by a subset of taste cells in adult rodents and appears on gustatory nerve fibers during development prior to differentiation of the taste buds. We employed antibodies against the extracellular domain of the NCAM polypeptide (mAb 3F4) and against polysialic acid (PSA) residues found on embryonic forms of NCAM (mAb 5A5) to investigate the relationship between the expression of these molecules and the innervation of taste buds in adult rats. In unoperated rats, anti-NCAM recognized a subset of cells within the vallate taste buds and also the fibers of the glossopharyngeal (IXth) nerve, including those innervating the gustatory epithelium. Taste bud cells did not express PSA but mAb 5A5 immunoreactivity was observed on some fibers of the IXth nerve, including a few that entered the taste buds. Bilateral crush of the IXth nerve resulted in the loss of NCAM expression from the gustatory epithelium within 8 days. As IXth nerve fibers reinnervated the epithelium, NCAM expression was seen first in the nerve, followed by increased expression in the epithelium as the taste cells differentiated from their precursors. PSA expression by fibers of the IXth nerve did not return to normal until well after the regeneration of the vallate taste buds. The present results demonstrate that taste cell expression of NCAM is dependent upon innervation by the IXth nerve and that NCAM expression appears in the nerve prior to its expression in the differentiating epithelium during regeneration. The occurrence of a similar temporal sequence in the developing taste system suggests that NCAM could play a role in cell-cell interactions that are important for the differentiation of the taste epithelium. Ongoing taste cell turnover and synaptogenesis between IXth nerve fibers and newly differentiating taste cells also requires recognition and adhesion, in which NCAM could play a role. © 1994 Wiley-Liss, Inc." @default.
• W2005992918 created "2016-06-24" @default.
• W2005992918 creator A5011022093 @default.
• W2005992918 creator A5032815396 @default.
• W2005992918 creator A5070030457 @default.
• W2005992918 creator A5090747573 @default.
• W2005992918 date "1994-09-08" @default.
• W2005992918 modified "2023-10-14" @default.
• W2005992918 title "Expression of the neural cell adhesion molecule (NCAM) and polysialic acid during taste bud degeneration and regeneration" @default.
• W2005992918 cites W1529295572 @default.
• W2005992918 cites W1541874566 @default.
• W2005992918 cites W1669628027 @default.
• W2005992918 cites W1757424920 @default.
• W2005992918 cites W1951533980 @default.
• W2005992918 cites W1965822810 @default.
• W2005992918 cites W1975741118 @default.
• W2005992918 cites W1979204241 @default.
• W2005992918 cites W1983794951 @default.
• W2005992918 cites W1987361669 @default.
• W2005992918 cites W1991451815 @default.
• W2005992918 cites W1995665862 @default.
• W2005992918 cites W2001657620 @default.
• W2005992918 cites W2003870531 @default.
• W2005992918 cites W2009566320 @default.
• W2005992918 cites W2011574427 @default.
• W2005992918 cites W2015472200 @default.
• W2005992918 cites W2015491187 @default.
• W2005992918 cites W2022988920 @default.
• W2005992918 cites W2032258193 @default.
• W2005992918 cites W2034780781 @default.
• W2005992918 cites W2036039321 @default.
• W2005992918 cites W2037230002 @default.
• W2005992918 cites W2044908499 @default.
• W2005992918 cites W2045871106 @default.
• W2005992918 cites W2046378363 @default.
• W2005992918 cites W2046793076 @default.
• W2005992918 cites W2050211473 @default.
• W2005992918 cites W2055906566 @default.
• W2005992918 cites W2056237490 @default.
• W2005992918 cites W2058301850 @default.
• W2005992918 cites W2063318786 @default.
• W2005992918 cites W2068439398 @default.
• W2005992918 cites W2070966930 @default.
• W2005992918 cites W2071792512 @default.
• W2005992918 cites W2090058363 @default.
• W2005992918 cites W2093513559 @default.
• W2005992918 cites W2125619554 @default.
• W2005992918 cites W2153144663 @default.
• W2005992918 cites W2162511272 @default.
• W2005992918 cites W2177077947 @default.
• W2005992918 cites W2179543029 @default.
• W2005992918 cites W85310861 @default.
• W2005992918 doi "https://doi.org/10.1002/cne.903470204" @default.
• W2005992918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7814663" @default.
• W2005992918 hasPublicationYear "1994" @default.
• W2005992918 type Work @default.
• W2005992918 sameAs 2005992918 @default.
• W2005992918 citedByCount "49" @default.
• W2005992918 countsByYear W20059929182015 @default.
• W2005992918 countsByYear W20059929182017 @default.
• W2005992918 countsByYear W20059929182019 @default.
• W2005992918 countsByYear W20059929182020 @default.
• W2005992918 crossrefType "journal-article" @default.
• W2005992918 hasAuthorship W2005992918A5011022093 @default.
• W2005992918 hasAuthorship W2005992918A5032815396 @default.
• W2005992918 hasAuthorship W2005992918A5070030457 @default.
• W2005992918 hasAuthorship W2005992918A5090747573 @default.
• W2005992918 hasConcept C122871604 @default.
• W2005992918 hasConcept C1491633281 @default.
• W2005992918 hasConcept C169760540 @default.
• W2005992918 hasConcept C171056886 @default.
• W2005992918 hasConcept C178006227 @default.
• W2005992918 hasConcept C2777687625 @default.
• W2005992918 hasConcept C2778993516 @default.
• W2005992918 hasConcept C529295009 @default.
• W2005992918 hasConcept C54355233 @default.
• W2005992918 hasConcept C55493867 @default.
• W2005992918 hasConcept C64375194 @default.
• W2005992918 hasConcept C85789140 @default.
• W2005992918 hasConcept C86803240 @default.
• W2005992918 hasConcept C8868529 @default.
• W2005992918 hasConcept C95444343 @default.
• W2005992918 hasConceptScore W2005992918C122871604 @default.
• W2005992918 hasConceptScore W2005992918C1491633281 @default.
• W2005992918 hasConceptScore W2005992918C169760540 @default.
• W2005992918 hasConceptScore W2005992918C171056886 @default.
• W2005992918 hasConceptScore W2005992918C178006227 @default.
• W2005992918 hasConceptScore W2005992918C2777687625 @default.
• W2005992918 hasConceptScore W2005992918C2778993516 @default.
• W2005992918 hasConceptScore W2005992918C529295009 @default.
• W2005992918 hasConceptScore W2005992918C54355233 @default.
• W2005992918 hasConceptScore W2005992918C55493867 @default.
• W2005992918 hasConceptScore W2005992918C64375194 @default.
• W2005992918 hasConceptScore W2005992918C85789140 @default.
• W2005992918 hasConceptScore W2005992918C86803240 @default.
• W2005992918 hasConceptScore W2005992918C8868529 @default.
• W2005992918 hasConceptScore W2005992918C95444343 @default.
• W2005992918 hasIssue "2" @default.

• next