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• W2005993464 abstract "ObjectiveThe aim of our study is to compare the ICSI outcome of coasted and non-coasted hyperresponder cycles.DesignRetrospective case-control studyMaterials and methodsFifty-two consecutive coasted and 86 non-coasted hyperresponder ICSI cycles were enrolled retrospectively via our computerized IVF database system from January 2001 to January 2004. All patients in coasted and non-coasted groups underwent controlled ovarian hyperstimulation consisting of luteal-long leuprolide acetate (Lucrin; Abbott, Cedex, Istanbul) with oral contraceptive pre-treatment (Lo-ovral; Wyeth, Istanbul) and recombinant FSH (Gonal-F; Serono, Istanbul) using the step-down protocol. Hyperresponse was considered when the serum E2 level >4,500 pg/mL with/without the hCG criteria (>3 follicles ≥17 mm in diameter). Two strategies were employed for hyperresponders: 1) coasting (n=52 cycles) and 2) immediate administration of hCG (10,000 IU) without coasting (n=86 cycles). Non-coasted patients were informed about the possible adverse affect of non-coasting including OHSS before the administration of hCG and were all chose the immediate administration of hCG. In coasted group, gonadotropin injections were withdrawn while the GnRH agonist was continued. Daily E2 was measured until serum levels dropped below 4500 pg/mL. Then, administration of hCG (10,000 IU, Profasi, Serono, Istanbul) was employed. The Chi-square and Fisher’s Exact test were used to analyze nominal variables in the form of frequency tables. Normally distributed (Kolmogorov-Smirnov test) parametric variables were tested by independent sample t test. Non-normally distributed metric variables were analyzed by Mann-Whitney U-test. Values were expressed as mean ±SD, unless stated otherwise.ResultsTabled 1Tabled 1ConclusionCoasting may be a viable option in hyperresponder cycles undergoing ICSI. There appears to be no detrimental effect on embryo quality and pregnancy rates are highly acceptable. Although, the numbers are limited, coasting does not eliminate totally the risk of severe OHSS necessitating hospitalization. ObjectiveThe aim of our study is to compare the ICSI outcome of coasted and non-coasted hyperresponder cycles. The aim of our study is to compare the ICSI outcome of coasted and non-coasted hyperresponder cycles. DesignRetrospective case-control study Retrospective case-control study Materials and methodsFifty-two consecutive coasted and 86 non-coasted hyperresponder ICSI cycles were enrolled retrospectively via our computerized IVF database system from January 2001 to January 2004. All patients in coasted and non-coasted groups underwent controlled ovarian hyperstimulation consisting of luteal-long leuprolide acetate (Lucrin; Abbott, Cedex, Istanbul) with oral contraceptive pre-treatment (Lo-ovral; Wyeth, Istanbul) and recombinant FSH (Gonal-F; Serono, Istanbul) using the step-down protocol. Hyperresponse was considered when the serum E2 level >4,500 pg/mL with/without the hCG criteria (>3 follicles ≥17 mm in diameter). Two strategies were employed for hyperresponders: 1) coasting (n=52 cycles) and 2) immediate administration of hCG (10,000 IU) without coasting (n=86 cycles). Non-coasted patients were informed about the possible adverse affect of non-coasting including OHSS before the administration of hCG and were all chose the immediate administration of hCG. In coasted group, gonadotropin injections were withdrawn while the GnRH agonist was continued. Daily E2 was measured until serum levels dropped below 4500 pg/mL. Then, administration of hCG (10,000 IU, Profasi, Serono, Istanbul) was employed. The Chi-square and Fisher’s Exact test were used to analyze nominal variables in the form of frequency tables. Normally distributed (Kolmogorov-Smirnov test) parametric variables were tested by independent sample t test. Non-normally distributed metric variables were analyzed by Mann-Whitney U-test. Values were expressed as mean ±SD, unless stated otherwise. Fifty-two consecutive coasted and 86 non-coasted hyperresponder ICSI cycles were enrolled retrospectively via our computerized IVF database system from January 2001 to January 2004. All patients in coasted and non-coasted groups underwent controlled ovarian hyperstimulation consisting of luteal-long leuprolide acetate (Lucrin; Abbott, Cedex, Istanbul) with oral contraceptive pre-treatment (Lo-ovral; Wyeth, Istanbul) and recombinant FSH (Gonal-F; Serono, Istanbul) using the step-down protocol. Hyperresponse was considered when the serum E2 level >4,500 pg/mL with/without the hCG criteria (>3 follicles ≥17 mm in diameter). Two strategies were employed for hyperresponders: 1) coasting (n=52 cycles) and 2) immediate administration of hCG (10,000 IU) without coasting (n=86 cycles). Non-coasted patients were informed about the possible adverse affect of non-coasting including OHSS before the administration of hCG and were all chose the immediate administration of hCG. In coasted group, gonadotropin injections were withdrawn while the GnRH agonist was continued. Daily E2 was measured until serum levels dropped below 4500 pg/mL. Then, administration of hCG (10,000 IU, Profasi, Serono, Istanbul) was employed. The Chi-square and Fisher’s Exact test were used to analyze nominal variables in the form of frequency tables. Normally distributed (Kolmogorov-Smirnov test) parametric variables were tested by independent sample t test. Non-normally distributed metric variables were analyzed by Mann-Whitney U-test. Values were expressed as mean ±SD, unless stated otherwise. ResultsTabled 1Tabled 1 ConclusionCoasting may be a viable option in hyperresponder cycles undergoing ICSI. There appears to be no detrimental effect on embryo quality and pregnancy rates are highly acceptable. Although, the numbers are limited, coasting does not eliminate totally the risk of severe OHSS necessitating hospitalization. Coasting may be a viable option in hyperresponder cycles undergoing ICSI. There appears to be no detrimental effect on embryo quality and pregnancy rates are highly acceptable. Although, the numbers are limited, coasting does not eliminate totally the risk of severe OHSS necessitating hospitalization." @default.
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• W2005993464 title "How to Deal Hyperresponders in ICSI? Coasting Versus Non-Coasting" @default.
• W2005993464 doi "https://doi.org/10.1016/j.fertnstert.2005.07.720" @default.
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