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• W2005994936 abstract "Chromatographic parameter assessments for RP-HPLC-UV method development for the simultaneous analysis of artemether and azithromycin for the pharmaceutical analysis of a rectal coformulation currently under development for the treatment of malaria infected children. Using methanol based mobile phase for the analysis of both artemether and azithromycin provided a more robust method in terms of resolution and peak symmetry. The method validated for suppository used 80% methanol and 20% phosphate buffer 15 mM at pH 9. The UV detection was at 210 nm. The accuracy profiles indicated a method validation between 80–120% for both active pharmaceutical ingredients. The preparation process of the suppository was validated based on theoretical values of artemether and azithromycin present in the formulation; active pharmaceutical ingredients were homogenously distributed within the suppository." @default.
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• W2005994936 date "2011-11-01" @default.
• W2005994936 modified "2023-09-26" @default.
• W2005994936 title "Simultaneous Determination of Artemether and Azithromycin in Suppositories by Reversed Phase HPLC" @default.
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• W2005994936 doi "https://doi.org/10.1080/00032719.2011.553014" @default.
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