FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006000827> ?p ?o ?g. }

• W2006000827 endingPage "366" @default.
• W2006000827 startingPage "351" @default.
• W2006000827 abstract "Although it is established that the fetus can successfully withstand a single, acute hypoxaemic challenge during gestation, little is known about what effects prevailing adverse intrauterine conditions might have on the fetal response to acute hypoxaemia. The aims of this study were therefore: (1) to characterise the effects of prevailing and sustained hypoxaemia, acidaemia or hypoglycaemia on the fetal cardiovascular responses to an episode of acute hypoxaemia; and (2) to determine the effects of these adverse intrauterine conditions on mechanisms mediating these cardiovascular responses. Thirty‐three Welsh Mountain sheep fetuses were chronically instrumented (1–2 % halothane) between 117 and 125 days of gestation (term is ca 145 days) with amniotic and vascular catheters and with a transit‐time flow probe around a femoral artery. The animals were divided retrospectively into four groups based upon post‐surgical, sustained, basal blood oxygen (chronically hypoxaemic; P a,O2 , 17.3 ± 0.5 mmHg; n = 8 ), glucose (chronically hypoglycaemic; blood glucose, 0.49 ± 0.03 mmol l −1 ; n = 6 ) and acid‐base (chronically acidaemic; pH a , 7.25 ± 0.01; n = 5 ) status. Values for compromised fetuses were −2 s.d. from a group of control ( n = 14 ) fetuses. At 130 ± 4 days, a 1 h episode of acute, isocapnic hypoxaemia (9 % O 2 in N 2 , to reduce carotid P a,O2 to 12 ± 1 mmHg) was induced in all fetuses by reducing the maternal inspired O 2 fraction ( F I,O2 ). Fetal cardiovascular variables were recorded at 1 s intervals throughout the experimental protocol and arterial blood samples taken at appropriate intervals for biophysical (blood gases, glucose, lactate) and endocrine (catecholamines, vasopressin, cortisol, ACTH) measures. During acute hypoxaemia all fetuses elicited hypertension, bradycardia and femoral vasoconstriction. However, prevailing fetal compromise altered the cardiovascular and endocrine responses to a further episode of acute hypoxaemia, including: (1) enhanced pressor and femoral vasoconstriction; (2) greater increments in plasma noradrenaline and vasopressin during hypoxaemia; and (3) basal upward resetting of hypothalamic‐pituitary‐adrenal axis function. Only chronically hypoxaemic fetuses had significantly elevated basal concentrations of noradrenaline and enhanced chemoreflex function during acute hypoxaemia. These data show that prevailing adverse intrauterine conditions alter the capacity of the fetus to respond to a subsequent episode of acute hypoxaemia; however, the partial contributions of hypoxaemia, acidaemia or hypoglycaemia to mediating these responses can vary." @default.
• W2006000827 created "2016-06-24" @default.
• W2006000827 creator A5009837161 @default.
• W2006000827 creator A5027105472 @default.
• W2006000827 creator A5032448804 @default.
• W2006000827 creator A5050299817 @default.
• W2006000827 creator A5065050579 @default.
• W2006000827 date "2002-04-01" @default.
• W2006000827 modified "2023-10-17" @default.
• W2006000827 title "Effects of prevailing hypoxaemia, acidaemia or hypoglycaemia upon the cardiovascular, endocrine and metabolic responses to acute hypoxaemia in the ovine fetus" @default.
• W2006000827 cites W1899805309 @default.
• W2006000827 cites W1968413151 @default.
• W2006000827 cites W1968486324 @default.
• W2006000827 cites W1973054301 @default.
• W2006000827 cites W1976885178 @default.
• W2006000827 cites W1992541271 @default.
• W2006000827 cites W1993384893 @default.
• W2006000827 cites W2000609745 @default.
• W2006000827 cites W2010371327 @default.
• W2006000827 cites W2011638545 @default.
• W2006000827 cites W2018593756 @default.
• W2006000827 cites W2021597987 @default.
• W2006000827 cites W2023154624 @default.
• W2006000827 cites W2028067695 @default.
• W2006000827 cites W2037743269 @default.
• W2006000827 cites W2042115152 @default.
• W2006000827 cites W2042786631 @default.
• W2006000827 cites W2049590346 @default.
• W2006000827 cites W2050956158 @default.
• W2006000827 cites W2060919866 @default.
• W2006000827 cites W2066848274 @default.
• W2006000827 cites W2070935687 @default.
• W2006000827 cites W2074079870 @default.
• W2006000827 cites W2077726441 @default.
• W2006000827 cites W2080605278 @default.
• W2006000827 cites W2084310196 @default.
• W2006000827 cites W2084744251 @default.
• W2006000827 cites W2087198940 @default.
• W2006000827 cites W2091474098 @default.
• W2006000827 cites W2094051830 @default.
• W2006000827 cites W2096193424 @default.
• W2006000827 cites W2100390170 @default.
• W2006000827 cites W2101972863 @default.
• W2006000827 cites W2115513517 @default.
• W2006000827 cites W2133081660 @default.
• W2006000827 cites W2148528339 @default.
• W2006000827 cites W2155168448 @default.
• W2006000827 cites W2157204902 @default.
• W2006000827 cites W2160929524 @default.
• W2006000827 cites W2162185423 @default.
• W2006000827 cites W2169983651 @default.
• W2006000827 cites W2170285625 @default.
• W2006000827 cites W2175047124 @default.
• W2006000827 cites W2202191889 @default.
• W2006000827 cites W2230733682 @default.
• W2006000827 cites W2232823122 @default.
• W2006000827 cites W2260129756 @default.
• W2006000827 cites W2278056160 @default.
• W2006000827 cites W2310914985 @default.
• W2006000827 cites W231534841 @default.
• W2006000827 cites W2337993986 @default.
• W2006000827 cites W2397756238 @default.
• W2006000827 cites W2400622616 @default.
• W2006000827 cites W2409113711 @default.
• W2006000827 cites W2410690230 @default.
• W2006000827 cites W2411528943 @default.
• W2006000827 cites W2414964796 @default.
• W2006000827 cites W2418135358 @default.
• W2006000827 cites W2418374707 @default.
• W2006000827 cites W2460475276 @default.
• W2006000827 cites W2461934576 @default.
• W2006000827 cites W2462066760 @default.
• W2006000827 cites W4237037958 @default.
• W2006000827 cites W4238432839 @default.
• W2006000827 cites W4289966260 @default.
• W2006000827 cites W4290360234 @default.
• W2006000827 cites W2403922417 @default.
• W2006000827 doi "https://doi.org/10.1113/jphysiol.2001.013434" @default.
• W2006000827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2290226" @default.
• W2006000827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11927692" @default.
• W2006000827 hasPublicationYear "2002" @default.
• W2006000827 type Work @default.
• W2006000827 sameAs 2006000827 @default.
• W2006000827 citedByCount "94" @default.
• W2006000827 countsByYear W20060008272012 @default.
• W2006000827 countsByYear W20060008272013 @default.
• W2006000827 countsByYear W20060008272015 @default.
• W2006000827 countsByYear W20060008272016 @default.
• W2006000827 countsByYear W20060008272017 @default.
• W2006000827 countsByYear W20060008272018 @default.
• W2006000827 countsByYear W20060008272019 @default.
• W2006000827 countsByYear W20060008272020 @default.
• W2006000827 countsByYear W20060008272021 @default.
• W2006000827 countsByYear W20060008272022 @default.
• W2006000827 countsByYear W20060008272023 @default.
• W2006000827 crossrefType "journal-article" @default.
• W2006000827 hasAuthorship W2006000827A5009837161 @default.
• W2006000827 hasAuthorship W2006000827A5027105472 @default.

• next