Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006005525> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2006005525 endingPage "265" @default.
- W2006005525 startingPage "259" @default.
- W2006005525 abstract "1. The multiple-dose kinetics of dapsone (DDS), its major metabolite monoacetyldapsone (MADDS) and pyrimethamine (PYR) were studied in six healthy adult male volunteers following weekly administration of Maloprim (100 mg DDS plus 12.5 mg PYR). 2. After the last maintenance dose of Maloprim, the following kinetic parameters (mean values) were determined for DDS and PYR, respectively: maximum plasma concentration (Cmax) = 1,134 and 116 ng ml-1; elimination half-life (t1/2) = 23 and 105 h; plasma clearance (CL) = 37.6 and 15.9 ml h-1 kg-1 and apparent volume of distribution (Vss) = 1.20 and 2.29 l kg-1. The mean t1/2 of MADDS was 22 h. 3. The mean whole blood to plasma (B/P) and erythrocyte to plasma (E/P) concentration ratios for DDS were 1.04 and 1.09, respectively. MADDS had a B/P ratio of 0.69 and an E/P ratio of 0.33. The B/P and E/P ratios for PYR were 0.98 and 0.54, respectively. 4. The drug combination was assessed in vitro by measuring inhibition of re-invasion of two Plasmodium falciparum isolates grown in the presence of volunteers' sera. The chloroquine (CQ)- and PYR-sensitive FC-27 isolate was completely inhibited by the sera but the drug combination was ineffective against the CQ- and PYR-resistant K1 strain. The in vitro findings suggest that Maloprim may not be effective against strains of P. falciparum with a high level of resistance to pyrimethamine." @default.
- W2006005525 created "2016-06-24" @default.
- W2006005525 creator A5003204240 @default.
- W2006005525 creator A5016014972 @default.
- W2006005525 creator A5072638559 @default.
- W2006005525 date "1990-08-01" @default.
- W2006005525 modified "2023-10-14" @default.
- W2006005525 title "Multiple-dose pharmacokinetics and in vitro antimalarial activity of dapsone plus pyrimethamine (Maloprim) in man." @default.
- W2006005525 cites W1964268338 @default.
- W2006005525 cites W197180234 @default.
- W2006005525 cites W1972926651 @default.
- W2006005525 cites W1973570197 @default.
- W2006005525 cites W1980565017 @default.
- W2006005525 cites W1981681516 @default.
- W2006005525 cites W1996808488 @default.
- W2006005525 cites W1998357893 @default.
- W2006005525 cites W203044230 @default.
- W2006005525 cites W2050297248 @default.
- W2006005525 cites W2054102092 @default.
- W2006005525 cites W2056454960 @default.
- W2006005525 cites W2078515066 @default.
- W2006005525 cites W2094805343 @default.
- W2006005525 cites W2095458479 @default.
- W2006005525 cites W2124291955 @default.
- W2006005525 cites W2157257600 @default.
- W2006005525 cites W2415838317 @default.
- W2006005525 cites W32365366 @default.
- W2006005525 cites W4301453911 @default.
- W2006005525 doi "https://doi.org/10.1111/j.1365-2125.1990.tb03773.x" @default.
- W2006005525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1368226" @default.
- W2006005525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2206787" @default.
- W2006005525 hasPublicationYear "1990" @default.
- W2006005525 type Work @default.
- W2006005525 sameAs 2006005525 @default.
- W2006005525 citedByCount "23" @default.
- W2006005525 countsByYear W20060055252012 @default.
- W2006005525 countsByYear W20060055252020 @default.
- W2006005525 crossrefType "journal-article" @default.
- W2006005525 hasAuthorship W2006005525A5003204240 @default.
- W2006005525 hasAuthorship W2006005525A5016014972 @default.
- W2006005525 hasAuthorship W2006005525A5072638559 @default.
- W2006005525 hasBestOaLocation W20060055252 @default.
- W2006005525 hasConcept C112705442 @default.
- W2006005525 hasConcept C139254425 @default.
- W2006005525 hasConcept C185592680 @default.
- W2006005525 hasConcept C202751555 @default.
- W2006005525 hasConcept C203014093 @default.
- W2006005525 hasConcept C22979827 @default.
- W2006005525 hasConcept C2777035104 @default.
- W2006005525 hasConcept C2777425658 @default.
- W2006005525 hasConcept C2777477808 @default.
- W2006005525 hasConcept C2777640609 @default.
- W2006005525 hasConcept C2778048844 @default.
- W2006005525 hasConcept C2778371730 @default.
- W2006005525 hasConcept C2779056493 @default.
- W2006005525 hasConcept C55493867 @default.
- W2006005525 hasConcept C71924100 @default.
- W2006005525 hasConcept C98274493 @default.
- W2006005525 hasConceptScore W2006005525C112705442 @default.
- W2006005525 hasConceptScore W2006005525C139254425 @default.
- W2006005525 hasConceptScore W2006005525C185592680 @default.
- W2006005525 hasConceptScore W2006005525C202751555 @default.
- W2006005525 hasConceptScore W2006005525C203014093 @default.
- W2006005525 hasConceptScore W2006005525C22979827 @default.
- W2006005525 hasConceptScore W2006005525C2777035104 @default.
- W2006005525 hasConceptScore W2006005525C2777425658 @default.
- W2006005525 hasConceptScore W2006005525C2777477808 @default.
- W2006005525 hasConceptScore W2006005525C2777640609 @default.
- W2006005525 hasConceptScore W2006005525C2778048844 @default.
- W2006005525 hasConceptScore W2006005525C2778371730 @default.
- W2006005525 hasConceptScore W2006005525C2779056493 @default.
- W2006005525 hasConceptScore W2006005525C55493867 @default.
- W2006005525 hasConceptScore W2006005525C71924100 @default.
- W2006005525 hasConceptScore W2006005525C98274493 @default.
- W2006005525 hasIssue "2" @default.
- W2006005525 hasLocation W20060055251 @default.
- W2006005525 hasLocation W20060055252 @default.
- W2006005525 hasLocation W20060055253 @default.
- W2006005525 hasLocation W20060055254 @default.
- W2006005525 hasOpenAccess W2006005525 @default.
- W2006005525 hasPrimaryLocation W20060055251 @default.
- W2006005525 hasRelatedWork W1487682541 @default.
- W2006005525 hasRelatedWork W1903390813 @default.
- W2006005525 hasRelatedWork W1970702698 @default.
- W2006005525 hasRelatedWork W1989295039 @default.
- W2006005525 hasRelatedWork W2006005525 @default.
- W2006005525 hasRelatedWork W2009510136 @default.
- W2006005525 hasRelatedWork W2056938528 @default.
- W2006005525 hasRelatedWork W2125585793 @default.
- W2006005525 hasRelatedWork W2463067141 @default.
- W2006005525 hasRelatedWork W3003535682 @default.
- W2006005525 hasVolume "30" @default.
- W2006005525 isParatext "false" @default.
- W2006005525 isRetracted "false" @default.
- W2006005525 magId "2006005525" @default.
- W2006005525 workType "article" @default.