FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006009764> ?p ?o ?g. }

• W2006009764 abstract "Hearing loss affects children with biotinidase deficiency, an inherited metabolic disorder in the recycling of biotin. The deficit appears shortly after birth during development of the auditory system. Using a mouse model, we sought to discover where and when biotinidase is expressed in the normal development of the cochlea and cochlear nucleus. In the process, we reconstructed the normal morphogenetic sequences of the constituent cells. Immunolabeling for biotinidase was localized to neurons and other cells of the adult and immature mouse, including the embryonic precursors of these regions dating from the stage of the otocyst. Its distribution was compared to the particular morphological changes occurring at each developmental stage. Biotinidase was localized in cells and their processes at the critical stages in their proliferation, migration, structural differentiation, and innervation, covering the entire span of their development. The prevalence of immunostaining peaked in the adult animal, including hair cells and ganglion cells of the cochlea and neurons of the cochlear nucleus. The findings suggest that biotinidase plays a role in the normal development of the auditory system. Besides the pattern of localization of biotinidase, this study provides the first systematic account of each developmental stage in a mammalian auditory system." @default.
• W2006009764 created "2016-06-24" @default.
• W2006009764 creator A5011283569 @default.
• W2006009764 creator A5020215478 @default.
• W2006009764 creator A5029002412 @default.
• W2006009764 creator A5036814559 @default.
• W2006009764 date "2005-11-01" @default.
• W2006009764 modified "2023-09-23" @default.
• W2006009764 title "Biotinidase reveals the morphogenetic sequence in cochlea and cochlear nucleus of mice" @default.
• W2006009764 cites W1409013807 @default.
• W2006009764 cites W1570232037 @default.
• W2006009764 cites W1753910563 @default.
• W2006009764 cites W1897638015 @default.
• W2006009764 cites W1972559506 @default.
• W2006009764 cites W1977014886 @default.
• W2006009764 cites W1977862446 @default.
• W2006009764 cites W1985416862 @default.
• W2006009764 cites W1997529183 @default.
• W2006009764 cites W2005558197 @default.
• W2006009764 cites W2010840768 @default.
• W2006009764 cites W2014183776 @default.
• W2006009764 cites W2030755571 @default.
• W2006009764 cites W2033010198 @default.
• W2006009764 cites W2033927122 @default.
• W2006009764 cites W2039834050 @default.
• W2006009764 cites W2040965251 @default.
• W2006009764 cites W2041675066 @default.
• W2006009764 cites W2046342066 @default.
• W2006009764 cites W2050117643 @default.
• W2006009764 cites W2057372009 @default.
• W2006009764 cites W2080120438 @default.
• W2006009764 cites W2081008600 @default.
• W2006009764 cites W2084538948 @default.
• W2006009764 cites W2114309709 @default.
• W2006009764 cites W2136159111 @default.
• W2006009764 cites W2160538256 @default.
• W2006009764 cites W2168944480 @default.
• W2006009764 cites W2317840819 @default.
• W2006009764 doi "https://doi.org/10.1016/j.heares.2005.06.013" @default.
• W2006009764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16107307" @default.
• W2006009764 hasPublicationYear "2005" @default.
• W2006009764 type Work @default.
• W2006009764 sameAs 2006009764 @default.
• W2006009764 citedByCount "7" @default.
• W2006009764 countsByYear W20060097642016 @default.
• W2006009764 countsByYear W20060097642017 @default.
• W2006009764 countsByYear W20060097642020 @default.
• W2006009764 crossrefType "journal-article" @default.
• W2006009764 hasAuthorship W2006009764A5011283569 @default.
• W2006009764 hasAuthorship W2006009764A5020215478 @default.
• W2006009764 hasAuthorship W2006009764A5029002412 @default.
• W2006009764 hasAuthorship W2006009764A5036814559 @default.
• W2006009764 hasConcept C105702510 @default.
• W2006009764 hasConcept C169760540 @default.
• W2006009764 hasConcept C203014093 @default.
• W2006009764 hasConcept C204232928 @default.
• W2006009764 hasConcept C2777443451 @default.
• W2006009764 hasConcept C2777662796 @default.
• W2006009764 hasConcept C2777877921 @default.
• W2006009764 hasConcept C2778038050 @default.
• W2006009764 hasConcept C2778204606 @default.
• W2006009764 hasConcept C2778415016 @default.
• W2006009764 hasConcept C2778500370 @default.
• W2006009764 hasConcept C2779152698 @default.
• W2006009764 hasConcept C2780130748 @default.
• W2006009764 hasConcept C2780723820 @default.
• W2006009764 hasConcept C4224716 @default.
• W2006009764 hasConcept C529278444 @default.
• W2006009764 hasConcept C54355233 @default.
• W2006009764 hasConcept C86803240 @default.
• W2006009764 hasConcept C95444343 @default.
• W2006009764 hasConceptScore W2006009764C105702510 @default.
• W2006009764 hasConceptScore W2006009764C169760540 @default.
• W2006009764 hasConceptScore W2006009764C203014093 @default.
• W2006009764 hasConceptScore W2006009764C204232928 @default.
• W2006009764 hasConceptScore W2006009764C2777443451 @default.
• W2006009764 hasConceptScore W2006009764C2777662796 @default.
• W2006009764 hasConceptScore W2006009764C2777877921 @default.
• W2006009764 hasConceptScore W2006009764C2778038050 @default.
• W2006009764 hasConceptScore W2006009764C2778204606 @default.
• W2006009764 hasConceptScore W2006009764C2778415016 @default.
• W2006009764 hasConceptScore W2006009764C2778500370 @default.
• W2006009764 hasConceptScore W2006009764C2779152698 @default.
• W2006009764 hasConceptScore W2006009764C2780130748 @default.
• W2006009764 hasConceptScore W2006009764C2780723820 @default.
• W2006009764 hasConceptScore W2006009764C4224716 @default.
• W2006009764 hasConceptScore W2006009764C529278444 @default.
• W2006009764 hasConceptScore W2006009764C54355233 @default.
• W2006009764 hasConceptScore W2006009764C86803240 @default.
• W2006009764 hasConceptScore W2006009764C95444343 @default.
• W2006009764 hasLocation W20060097641 @default.
• W2006009764 hasLocation W20060097642 @default.
• W2006009764 hasOpenAccess W2006009764 @default.
• W2006009764 hasPrimaryLocation W20060097641 @default.
• W2006009764 hasRelatedWork W1993879972 @default.
• W2006009764 hasRelatedWork W2006009764 @default.
• W2006009764 hasRelatedWork W2052424440 @default.
• W2006009764 hasRelatedWork W2056407069 @default.
• W2006009764 hasRelatedWork W2071641360 @default.
• W2006009764 hasRelatedWork W2077359511 @default.

• next