FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006010807> ?p ?o ?g. }

• W2006010807 endingPage "234" @default.
• W2006010807 startingPage "224" @default.
• W2006010807 abstract "Vascular endothelial growth factor (VEGF), a potent angiogenic molecule specific for vascular endothelial cells, is overexpressed in most tumors and closely associated with tumor growth and metastasis. It has been shown that a soluble fragment of VEGF receptor Flt-1 (sFlt-1) has anti-angiogenic properties by way of its antagonist activity against VEGF. In the present study, we demonstrated that the stable expression of sFlt-1 by endothelial cell targeted non-viral gene delivery inhibited the angiogenesis of endothelial cells. A targeted polymeric gene delivery system, PEI-g-PEG-RGD, was developed by incorporating the ανβ3/ανβ5 integrin-binding RGD peptide, ACDCRGDCFC (single-letter amino acid code), into the cationic polymer, polyethylenimine (PEI) via a hydrophilic polyethylene glycol (PEG) spacer. The functional analysis of therapeutic gene encoding sFlt-1/carrier complex was performed with an endothelial cell proliferation assay. The complex of sFlt-1 gene with PEI-g-PEG-RGD conjugate efficiently inhibited the proliferation of cultured endothelial cells, representing that expressed sFlt-1 predominantly bound to exogenous VEGF and blocked the binding of VEGF to the full-length Flt-1 receptor. These findings suggest that the combination of targeted gene carrier and sFlt-1 possesses the potential to be an efficient tool for the anti-angiogenic gene therapy to treat cancer." @default.
• W2006010807 created "2016-06-24" @default.
• W2006010807 creator A5003478304 @default.
• W2006010807 creator A5034805413 @default.
• W2006010807 creator A5056065669 @default.
• W2006010807 creator A5065006809 @default.
• W2006010807 creator A5078667650 @default.
• W2006010807 creator A5087335534 @default.
• W2006010807 date "2005-08-01" @default.
• W2006010807 modified "2023-10-11" @default.
• W2006010807 title "Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis" @default.
• W2006010807 cites W1621599087 @default.
• W2006010807 cites W1941829554 @default.
• W2006010807 cites W1981612052 @default.
• W2006010807 cites W1983763042 @default.
• W2006010807 cites W1986469266 @default.
• W2006010807 cites W1999647970 @default.
• W2006010807 cites W2001728487 @default.
• W2006010807 cites W2010655741 @default.
• W2006010807 cites W2024719999 @default.
• W2006010807 cites W2026038921 @default.
• W2006010807 cites W2029763523 @default.
• W2006010807 cites W2043297474 @default.
• W2006010807 cites W2043850275 @default.
• W2006010807 cites W2043863730 @default.
• W2006010807 cites W2048928172 @default.
• W2006010807 cites W2049972026 @default.
• W2006010807 cites W2050865455 @default.
• W2006010807 cites W2067055586 @default.
• W2006010807 cites W2072446438 @default.
• W2006010807 cites W2072928113 @default.
• W2006010807 cites W2075820020 @default.
• W2006010807 cites W2080688395 @default.
• W2006010807 cites W2084506573 @default.
• W2006010807 cites W2088272913 @default.
• W2006010807 cites W2114098415 @default.
• W2006010807 cites W2114286636 @default.
• W2006010807 cites W2116071714 @default.
• W2006010807 cites W2126630077 @default.
• W2006010807 cites W2131798870 @default.
• W2006010807 cites W4245635197 @default.
• W2006010807 cites W4250893695 @default.
• W2006010807 doi "https://doi.org/10.1016/j.jconrel.2005.04.016" @default.
• W2006010807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15970348" @default.
• W2006010807 hasPublicationYear "2005" @default.
• W2006010807 type Work @default.
• W2006010807 sameAs 2006010807 @default.
• W2006010807 citedByCount "120" @default.
• W2006010807 countsByYear W20060108072012 @default.
• W2006010807 countsByYear W20060108072013 @default.
• W2006010807 countsByYear W20060108072014 @default.
• W2006010807 countsByYear W20060108072015 @default.
• W2006010807 countsByYear W20060108072016 @default.
• W2006010807 countsByYear W20060108072017 @default.
• W2006010807 countsByYear W20060108072018 @default.
• W2006010807 countsByYear W20060108072019 @default.
• W2006010807 countsByYear W20060108072020 @default.
• W2006010807 countsByYear W20060108072021 @default.
• W2006010807 countsByYear W20060108072022 @default.
• W2006010807 crossrefType "journal-article" @default.
• W2006010807 hasAuthorship W2006010807A5003478304 @default.
• W2006010807 hasAuthorship W2006010807A5034805413 @default.
• W2006010807 hasAuthorship W2006010807A5056065669 @default.
• W2006010807 hasAuthorship W2006010807A5065006809 @default.
• W2006010807 hasAuthorship W2006010807A5078667650 @default.
• W2006010807 hasAuthorship W2006010807A5087335534 @default.
• W2006010807 hasConcept C104317684 @default.
• W2006010807 hasConcept C111599444 @default.
• W2006010807 hasConcept C123012128 @default.
• W2006010807 hasConcept C134306372 @default.
• W2006010807 hasConcept C135983454 @default.
• W2006010807 hasConcept C153911025 @default.
• W2006010807 hasConcept C167734588 @default.
• W2006010807 hasConcept C185592680 @default.
• W2006010807 hasConcept C197336794 @default.
• W2006010807 hasConcept C202751555 @default.
• W2006010807 hasConcept C2775925850 @default.
• W2006010807 hasConcept C2777025900 @default.
• W2006010807 hasConcept C2780394083 @default.
• W2006010807 hasConcept C33923547 @default.
• W2006010807 hasConcept C502942594 @default.
• W2006010807 hasConcept C54009773 @default.
• W2006010807 hasConcept C55493867 @default.
• W2006010807 hasConcept C86803240 @default.
• W2006010807 hasConcept C95444343 @default.
• W2006010807 hasConceptScore W2006010807C104317684 @default.
• W2006010807 hasConceptScore W2006010807C111599444 @default.
• W2006010807 hasConceptScore W2006010807C123012128 @default.
• W2006010807 hasConceptScore W2006010807C134306372 @default.
• W2006010807 hasConceptScore W2006010807C135983454 @default.
• W2006010807 hasConceptScore W2006010807C153911025 @default.
• W2006010807 hasConceptScore W2006010807C167734588 @default.
• W2006010807 hasConceptScore W2006010807C185592680 @default.
• W2006010807 hasConceptScore W2006010807C197336794 @default.
• W2006010807 hasConceptScore W2006010807C202751555 @default.
• W2006010807 hasConceptScore W2006010807C2775925850 @default.
• W2006010807 hasConceptScore W2006010807C2777025900 @default.
• W2006010807 hasConceptScore W2006010807C2780394083 @default.

• next