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- W2006016787 abstract "Significance Diabetes is the leading cause of nontraumatic amputations. There are no effective therapies to prevent diabetic ulcer formation and only modestly effective technologies to help with their healing. To enhance diabetic wound healing we designed a transdermal delivery system containing the FDA-approved small molecule deferoxamine, an iron chelator that increases defective hypoxia inducible factor-1 alpha transactivation in diabetes by preventing iron-catalyzed reactive oxygen stress. This system overcomes the challenge of delivering hydrophilic molecules through the normally impermeable stratum corneum and both prevents diabetic ulcer formation and improves the healing of existing diabetic wounds. This represents a prophylactic pharmacological agent to prevent ulcer formation that is rapidly translatable into the clinic and has the potential to ultimately transform the care and prevention of diabetic complications." @default.
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- W2006016787 date "2014-12-22" @default.
- W2006016787 modified "2023-10-10" @default.
- W2006016787 title "Transdermal deferoxamine prevents pressure-induced diabetic ulcers" @default.
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- W2006016787 doi "https://doi.org/10.1073/pnas.1413445112" @default.
- W2006016787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4291638" @default.
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- W2006016787 hasPublicationYear "2014" @default.
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