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• W2006020908 abstract "Utilizing mefloquine as a scaffold, a next generation quinoline methanol (NGQM) library was constructed to identify early lead compounds that possess biological properties consistent with the target product profile for malaria chemoprophylaxis while reducing permeability across the blood-brain barrier. The library of 200 analogs resulted in compounds that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. Herein we report selected chemotypes and the emerging structure-activity relationship for this library of quinoline methanols." @default.
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• W2006020908 date "2010-02-01" @default.
• W2006020908 modified "2023-10-14" @default.
• W2006020908 title "Structure–activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum" @default.
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• W2006020908 doi "https://doi.org/10.1016/j.bmcl.2010.01.001" @default.
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