FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006022966> ?p ?o ?g. }

• W2006022966 endingPage "e1002816" @default.
• W2006022966 startingPage "e1002816" @default.
• W2006022966 abstract "Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen, which is cross-resistant to virtually all β-lactam antibiotics. MRSA strains are defined by the presence of mecA gene. The transcription of mecA can be regulated by a sensor-inducer (MecR1) and a repressor (MecI), involving a unique series of proteolytic steps. The induction of mecA by MecR1 has been described as very inefficient and, as such, it is believed that optimal expression of β-lactam resistance by MRSA requires a non-functional MecR1-MecI system. However, in a recent study, no correlation was found between the presence of functional MecR1-MecI and the level of β-lactam resistance in a representative collection of epidemic MRSA strains. Here, we demonstrate that the mecA regulatory locus consists, in fact, of an unusual three-component arrangement containing, in addition to mecR1-mecI, the up to now unrecognized mecR2 gene coding for an anti-repressor. The MecR2 function is essential for the full induction of mecA expression, compensating for the inefficient induction of mecA by MecR1 and enabling optimal expression of β-lactam resistance in MRSA strains with functional mecR1-mecI regulatory genes. Our data shows that MecR2 interacts directly with MecI, destabilizing its binding to the mecA promoter, which results in the repressor inactivation by proteolytic cleavage, presumably mediated by native cytoplasmatic proteases. These observations point to a revision of the current model for the transcriptional control of mecA and open new avenues for the design of alternative therapeutic strategies for the treatment of MRSA infections. Moreover, these findings also provide important insights into the complex evolutionary pathways of antibiotic resistance and molecular mechanisms of transcriptional regulation in bacteria." @default.
• W2006022966 created "2016-06-24" @default.
• W2006022966 creator A5001795167 @default.
• W2006022966 creator A5004638611 @default.
• W2006022966 creator A5022859756 @default.
• W2006022966 creator A5076223619 @default.
• W2006022966 date "2012-07-26" @default.
• W2006022966 modified "2023-09-27" @default.
• W2006022966 title "The Anti-Repressor MecR2 Promotes the Proteolysis of the mecA Repressor and Enables Optimal Expression of β-lactam Resistance in MRSA" @default.
• W2006022966 cites W1544399693 @default.
• W2006022966 cites W1585468492 @default.
• W2006022966 cites W1586957091 @default.
• W2006022966 cites W1593572782 @default.
• W2006022966 cites W1678334574 @default.
• W2006022966 cites W1864055940 @default.
• W2006022966 cites W1877167201 @default.
• W2006022966 cites W1880415380 @default.
• W2006022966 cites W1910427409 @default.
• W2006022966 cites W1923228262 @default.
• W2006022966 cites W1980030331 @default.
• W2006022966 cites W1980659704 @default.
• W2006022966 cites W1983878906 @default.
• W2006022966 cites W1985377557 @default.
• W2006022966 cites W1988681379 @default.
• W2006022966 cites W1996396935 @default.
• W2006022966 cites W2001394772 @default.
• W2006022966 cites W2003757150 @default.
• W2006022966 cites W2005092009 @default.
• W2006022966 cites W2005695870 @default.
• W2006022966 cites W2011591718 @default.
• W2006022966 cites W2012952588 @default.
• W2006022966 cites W2017349971 @default.
• W2006022966 cites W2017618879 @default.
• W2006022966 cites W2020942122 @default.
• W2006022966 cites W2047670590 @default.
• W2006022966 cites W2050066382 @default.
• W2006022966 cites W2050460020 @default.
• W2006022966 cites W2051464239 @default.
• W2006022966 cites W2055046750 @default.
• W2006022966 cites W2081947485 @default.
• W2006022966 cites W2084760062 @default.
• W2006022966 cites W2088319417 @default.
• W2006022966 cites W2092643722 @default.
• W2006022966 cites W2100932565 @default.
• W2006022966 cites W2108643808 @default.
• W2006022966 cites W2110270806 @default.
• W2006022966 cites W2111241008 @default.
• W2006022966 cites W2116607488 @default.
• W2006022966 cites W211922450 @default.
• W2006022966 cites W2120593627 @default.
• W2006022966 cites W2120623776 @default.
• W2006022966 cites W2121867408 @default.
• W2006022966 cites W2122056326 @default.
• W2006022966 cites W2131796599 @default.
• W2006022966 cites W2136345186 @default.
• W2006022966 cites W2136394507 @default.
• W2006022966 cites W2136761329 @default.
• W2006022966 cites W2137367576 @default.
• W2006022966 cites W2144147504 @default.
• W2006022966 cites W2148663866 @default.
• W2006022966 cites W2151150074 @default.
• W2006022966 cites W2155417557 @default.
• W2006022966 cites W2159308620 @default.
• W2006022966 cites W2161582833 @default.
• W2006022966 cites W2168482920 @default.
• W2006022966 cites W2170205901 @default.
• W2006022966 cites W2287677122 @default.
• W2006022966 cites W2314649741 @default.
• W2006022966 cites W4240985978 @default.
• W2006022966 doi "https://doi.org/10.1371/journal.ppat.1002816" @default.
• W2006022966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3406092" @default.
• W2006022966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22911052" @default.
• W2006022966 hasPublicationYear "2012" @default.
• W2006022966 type Work @default.
• W2006022966 sameAs 2006022966 @default.
• W2006022966 citedByCount "40" @default.
• W2006022966 countsByYear W20060229662012 @default.
• W2006022966 countsByYear W20060229662013 @default.
• W2006022966 countsByYear W20060229662014 @default.
• W2006022966 countsByYear W20060229662015 @default.
• W2006022966 countsByYear W20060229662016 @default.
• W2006022966 countsByYear W20060229662017 @default.
• W2006022966 countsByYear W20060229662018 @default.
• W2006022966 countsByYear W20060229662019 @default.
• W2006022966 countsByYear W20060229662021 @default.
• W2006022966 countsByYear W20060229662022 @default.
• W2006022966 countsByYear W20060229662023 @default.
• W2006022966 crossrefType "journal-article" @default.
• W2006022966 hasAuthorship W2006022966A5001795167 @default.
• W2006022966 hasAuthorship W2006022966A5004638611 @default.
• W2006022966 hasAuthorship W2006022966A5022859756 @default.
• W2006022966 hasAuthorship W2006022966A5076223619 @default.
• W2006022966 hasBestOaLocation W20060229661 @default.
• W2006022966 hasConcept C104317684 @default.
• W2006022966 hasConcept C150194340 @default.
• W2006022966 hasConcept C158448853 @default.
• W2006022966 hasConcept C2225953 @default.
• W2006022966 hasConcept C2776653525 @default.

• next