FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006024698> ?p ?o ?g. }

• W2006024698 endingPage "238" @default.
• W2006024698 startingPage "229" @default.
• W2006024698 abstract "Annexins are a structurally related family of Ca2+ binding proteins of undertermined biological function. Annexin I (also called lipocortin 1) is a substrate for the EGF-stimulated tyrosine kinase and is postulated to be involved in mitogenic signal transduction. To investigate further the involvement of lipocortin 1 in cell proliferation, we measured lipocortin 1 levels in normal diploid human foreskin fibroblasts (HFF) to determine whether its expression changed as a function of growth status. For comparison, the expression of annexin V (also called endonexin II) was measured in HFF cells. Endonexin II is a protein with similar Ca2+ and phospholipid binding properties as lipocortin 1, but it is not a substrate for tyrosine kinases. Quiescent HFF cell cultures were induced to proliferate by either subculture to lower cell density, EGF stimulation, or serum stimulation. In all three protocols, proliferating HFF cells contained three- to fourfold higher levels of lipocortin 1 and three- to fourfold lower levels of endonexin II than quiescent HFF cells. In contrast, the expression of annexin II (also called calpactin I) and annexin IV (also called endonexin I) remained relatively unchanged in growing and quiescent HFF cells. Lipocortin 1 synthesis rate was eightfold higher and its turnover rate was 1.5-fold slower in proliferating compared to quiescent HFF cells. Endonexin II synthesis rate remained constant but its turnover rate was 2.2-fold faster in proliferating compared to quiescent HFF cells. In a separate set of experiments, annexin expression levels were measured in cultures of rat PC-12 cells, a pheochromocytoma that ceases proliferation and undergoes reversible differentiation into nondividing neuronlike cells in response to nerve growth factor (NGF). After NGF treatment, PC-12 cells expressed fivefold higher levels of endonexin II and 32-fold higher levels of calpactin 1. Lipocortin 1 and endonexin I were not expressed in PC-12 cells. In summary, lipocortin 1 expression exhibited a positive correlation with cell proliferation in HFF cells. The increased expression of endonexin II in quiescent HFF cells and differentiating PC-12 cells implies that this protein may play a more prominent role in nondividing cells." @default.
• W2006024698 created "2016-06-24" @default.
• W2006024698 creator A5047955169 @default.
• W2006024698 creator A5090973852 @default.
• W2006024698 date "1990-07-01" @default.
• W2006024698 modified "2023-09-25" @default.
• W2006024698 title "Expression of annexins as a function of cellular growth state." @default.
• W2006024698 cites W144955152 @default.
• W2006024698 cites W1500462989 @default.
• W2006024698 cites W1501977647 @default.
• W2006024698 cites W1510923466 @default.
• W2006024698 cites W1532866634 @default.
• W2006024698 cites W1554938621 @default.
• W2006024698 cites W1563946901 @default.
• W2006024698 cites W1582315378 @default.
• W2006024698 cites W1583855854 @default.
• W2006024698 cites W1586330982 @default.
• W2006024698 cites W1596621116 @default.
• W2006024698 cites W1600235198 @default.
• W2006024698 cites W1605429420 @default.
• W2006024698 cites W1616231937 @default.
• W2006024698 cites W1772688478 @default.
• W2006024698 cites W1959383367 @default.
• W2006024698 cites W1966219177 @default.
• W2006024698 cites W1969422658 @default.
• W2006024698 cites W1970587959 @default.
• W2006024698 cites W1977158442 @default.
• W2006024698 cites W1978628350 @default.
• W2006024698 cites W1988885639 @default.
• W2006024698 cites W1996683778 @default.
• W2006024698 cites W1996963674 @default.
• W2006024698 cites W2004744930 @default.
• W2006024698 cites W2018289835 @default.
• W2006024698 cites W2020977807 @default.
• W2006024698 cites W2034139292 @default.
• W2006024698 cites W2038415252 @default.
• W2006024698 cites W2041107578 @default.
• W2006024698 cites W2048375895 @default.
• W2006024698 cites W2052954947 @default.
• W2006024698 cites W2066359068 @default.
• W2006024698 cites W2079134774 @default.
• W2006024698 cites W2085292543 @default.
• W2006024698 cites W2086145897 @default.
• W2006024698 cites W2090979911 @default.
• W2006024698 cites W2091557564 @default.
• W2006024698 cites W2100837269 @default.
• W2006024698 cites W2101108802 @default.
• W2006024698 cites W2102686118 @default.
• W2006024698 cites W2113225489 @default.
• W2006024698 cites W2136536126 @default.
• W2006024698 cites W2143064177 @default.
• W2006024698 cites W2164864625 @default.
• W2006024698 cites W2315337158 @default.
• W2006024698 cites W309529471 @default.
• W2006024698 doi "https://doi.org/10.1083/jcb.111.1.229" @default.
• W2006024698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2116158" @default.
• W2006024698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2142163" @default.
• W2006024698 hasPublicationYear "1990" @default.
• W2006024698 type Work @default.
• W2006024698 sameAs 2006024698 @default.
• W2006024698 citedByCount "155" @default.
• W2006024698 countsByYear W20060246982012 @default.
• W2006024698 countsByYear W20060246982013 @default.
• W2006024698 countsByYear W20060246982014 @default.
• W2006024698 countsByYear W20060246982015 @default.
• W2006024698 countsByYear W20060246982017 @default.
• W2006024698 countsByYear W20060246982019 @default.
• W2006024698 countsByYear W20060246982020 @default.
• W2006024698 crossrefType "journal-article" @default.
• W2006024698 hasAuthorship W2006024698A5047955169 @default.
• W2006024698 hasAuthorship W2006024698A5090973852 @default.
• W2006024698 hasBestOaLocation W20060246981 @default.
• W2006024698 hasConcept C11960822 @default.
• W2006024698 hasConcept C126322002 @default.
• W2006024698 hasConcept C134018914 @default.
• W2006024698 hasConcept C153911025 @default.
• W2006024698 hasConcept C2776165026 @default.
• W2006024698 hasConcept C2777553839 @default.
• W2006024698 hasConcept C2780670749 @default.
• W2006024698 hasConcept C30345302 @default.
• W2006024698 hasConcept C42362537 @default.
• W2006024698 hasConcept C54355233 @default.
• W2006024698 hasConcept C553184892 @default.
• W2006024698 hasConcept C55493867 @default.
• W2006024698 hasConcept C62112901 @default.
• W2006024698 hasConcept C62478195 @default.
• W2006024698 hasConcept C68246026 @default.
• W2006024698 hasConcept C71924100 @default.
• W2006024698 hasConcept C81885089 @default.
• W2006024698 hasConcept C86803240 @default.
• W2006024698 hasConcept C88634738 @default.
• W2006024698 hasConcept C95444343 @default.
• W2006024698 hasConceptScore W2006024698C11960822 @default.
• W2006024698 hasConceptScore W2006024698C126322002 @default.
• W2006024698 hasConceptScore W2006024698C134018914 @default.
• W2006024698 hasConceptScore W2006024698C153911025 @default.
• W2006024698 hasConceptScore W2006024698C2776165026 @default.
• W2006024698 hasConceptScore W2006024698C2777553839 @default.

• next