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- W2006024998 abstract "Isotonic Design using Normalized Equivalent Toxicity Score (ID-NETS) is a novel Phase I design that integrates the novel toxicity scoring system originally proposed by Chen et al . [1] and the original Isotonic Design proposed by Leung et al . [2]. ID-NETS has substantially improved the accuracy of maximum tolerated dose (MTD) estimation and trial efficiency in the Phase I clinical trial setting by fully utilizing all toxicities experienced by each patient and treating toxicity response as a quasi-continuous variable instead of a binary indicator of dose limiting toxicity (DLT). To facilitate the incorporation of the ID-NETS method into the design and conduct of Phase I clinical trials, we have designed and developed a user-friendly software, ID-NETS ©TM , which has two functions: 1) Calculating the recommended dose for the subsequent patient cohort using available completed data; and 2) Performing simulations to obtain the operating characteristics of a trial designed with ID-NETS. Currently, ID-NETS ©TM v1.0 is available for free download at (http://winshipbbisr.emory.edu/IDNETS.html) ." @default.
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- W2006024998 date "2013-04-05" @default.
- W2006024998 modified "2023-09-26" @default.
- W2006024998 title "Interactive Software “Isotonic Design using Normalized Equivalent Toxicity Score (ID-NETS©TM)” for Cancer Phase I Clinical Trials" @default.
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- W2006024998 doi "https://doi.org/10.2174/1874431101307010008" @default.
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