FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006025086> ?p ?o ?g. }

• W2006025086 endingPage "19303" @default.
• W2006025086 startingPage "19298" @default.
• W2006025086 abstract "Tissue morphogenesis is the process in which coordinated movements and shape changes of large numbers of cells form tissues, organs, and the internal body structure. Understanding morphogenetic movements requires precise measurements of whole-cell shape changes over time. Tissue folding and invagination are thought to be facilitated by apical constriction, but the mechanism by which changes near the apical cell surface affect changes along the entire apical–basal axis of the cell remains elusive. Here, we developed Embryo Development Geometry Explorer, an approach for quantifying rapid whole-cell shape changes over time, and we combined it with deep-tissue time-lapse imaging based on fast two-photon microscopy to study Drosophila ventral furrow formation. We found that both the cell lengthening along the apical–basal axis and the movement of the nucleus to the basal side proceeded stepwise and were correlated with apical constriction. Moreover, cell volume lost apically due to constriction largely balanced the volume gained basally by cell lengthening. The volume above the nucleus was conserved during its basal movement. Both apical volume loss and cell lengthening were absent in mutants showing deficits in the contractile cytoskeleton underlying apical constriction. We conclude that a single mechanical mechanism involving volume conservation and apical constriction-induced basal movement of cytoplasm accounts quantitatively for the cell shape changes and the nucleus movement in Drosophila ventral furrow formation. Our study provides a comprehensive quantitative analysis of the fast dynamics of whole-cell shape changes during tissue folding and points to a simplified model for Drosophila gastrulation." @default.
• W2006025086 created "2016-06-24" @default.
• W2006025086 creator A5006975038 @default.
• W2006025086 creator A5023889128 @default.
• W2006025086 creator A5039902970 @default.
• W2006025086 creator A5066601492 @default.
• W2006025086 creator A5069521471 @default.
• W2006025086 creator A5083154783 @default.
• W2006025086 date "2012-11-07" @default.
• W2006025086 modified "2023-10-12" @default.
• W2006025086 title "Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis" @default.
• W2006025086 cites W1523685816 @default.
• W2006025086 cites W1600007595 @default.
• W2006025086 cites W1755300801 @default.
• W2006025086 cites W1866991157 @default.
• W2006025086 cites W1881600462 @default.
• W2006025086 cites W1969714257 @default.
• W2006025086 cites W1969967829 @default.
• W2006025086 cites W1977786555 @default.
• W2006025086 cites W1979366429 @default.
• W2006025086 cites W1980908755 @default.
• W2006025086 cites W1987817703 @default.
• W2006025086 cites W1990221937 @default.
• W2006025086 cites W1992260947 @default.
• W2006025086 cites W1994525772 @default.
• W2006025086 cites W1998888750 @default.
• W2006025086 cites W2004655327 @default.
• W2006025086 cites W2013843350 @default.
• W2006025086 cites W2015357416 @default.
• W2006025086 cites W2019427680 @default.
• W2006025086 cites W2027367584 @default.
• W2006025086 cites W2028154752 @default.
• W2006025086 cites W2057796254 @default.
• W2006025086 cites W2061464631 @default.
• W2006025086 cites W2073214979 @default.
• W2006025086 cites W2090817340 @default.
• W2006025086 cites W2107554012 @default.
• W2006025086 cites W2107973236 @default.
• W2006025086 cites W2110759931 @default.
• W2006025086 cites W2121071682 @default.
• W2006025086 cites W2121405186 @default.
• W2006025086 cites W2128339343 @default.
• W2006025086 cites W2130623599 @default.
• W2006025086 cites W2149141774 @default.
• W2006025086 cites W2167463357 @default.
• W2006025086 cites W2169338512 @default.
• W2006025086 cites W2254380769 @default.
• W2006025086 doi "https://doi.org/10.1073/pnas.1205258109" @default.
• W2006025086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3511084" @default.
• W2006025086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23134725" @default.
• W2006025086 hasPublicationYear "2012" @default.
• W2006025086 type Work @default.
• W2006025086 sameAs 2006025086 @default.
• W2006025086 citedByCount "111" @default.
• W2006025086 countsByYear W20060250862013 @default.
• W2006025086 countsByYear W20060250862014 @default.
• W2006025086 countsByYear W20060250862015 @default.
• W2006025086 countsByYear W20060250862016 @default.
• W2006025086 countsByYear W20060250862017 @default.
• W2006025086 countsByYear W20060250862018 @default.
• W2006025086 countsByYear W20060250862019 @default.
• W2006025086 countsByYear W20060250862020 @default.
• W2006025086 countsByYear W20060250862021 @default.
• W2006025086 countsByYear W20060250862022 @default.
• W2006025086 countsByYear W20060250862023 @default.
• W2006025086 crossrefType "journal-article" @default.
• W2006025086 hasAuthorship W2006025086A5006975038 @default.
• W2006025086 hasAuthorship W2006025086A5023889128 @default.
• W2006025086 hasAuthorship W2006025086A5039902970 @default.
• W2006025086 hasAuthorship W2006025086A5066601492 @default.
• W2006025086 hasAuthorship W2006025086A5069521471 @default.
• W2006025086 hasAuthorship W2006025086A5083154783 @default.
• W2006025086 hasBestOaLocation W20060250861 @default.
• W2006025086 hasConcept C104317684 @default.
• W2006025086 hasConcept C105702510 @default.
• W2006025086 hasConcept C129536746 @default.
• W2006025086 hasConcept C134018914 @default.
• W2006025086 hasConcept C134867827 @default.
• W2006025086 hasConcept C1491633281 @default.
• W2006025086 hasConcept C174940676 @default.
• W2006025086 hasConcept C176080148 @default.
• W2006025086 hasConcept C190062978 @default.
• W2006025086 hasConcept C196843134 @default.
• W2006025086 hasConcept C2780723820 @default.
• W2006025086 hasConcept C39579648 @default.
• W2006025086 hasConcept C40692019 @default.
• W2006025086 hasConcept C45472230 @default.
• W2006025086 hasConcept C54355233 @default.
• W2006025086 hasConcept C55493867 @default.
• W2006025086 hasConcept C85813293 @default.
• W2006025086 hasConcept C86803240 @default.
• W2006025086 hasConcept C87073359 @default.
• W2006025086 hasConcept C95444343 @default.
• W2006025086 hasConceptScore W2006025086C104317684 @default.
• W2006025086 hasConceptScore W2006025086C105702510 @default.
• W2006025086 hasConceptScore W2006025086C129536746 @default.
• W2006025086 hasConceptScore W2006025086C134018914 @default.
• W2006025086 hasConceptScore W2006025086C134867827 @default.

• next