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• W2006029648 abstract "Some new (2′–5′)oligoadenylate trimers, i.e., 22–28, containing the antiviral nucleoside ribavirin (= 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide; 7) and the synthetic cytokine 6-(benzylamino)purine riboside (= N6-benzyladenosine; 1) in different positions of the trimer, have been synthesized by the phosphotriester method. The selectively blocked nucleosides 2–6 and 8–11 and the 2′-phosphodiesters 13 and 14, used for the oligonucleotide syntheses, were synthesized from the corresponding unprotected ribonucleosides 1 and 7, and isolated by silica-gel column chromatography. The fully deblocked trimers 22–28 were purified by ion-exchange chromatography on DEAE-Senacell 23-SS. The newly synthesized compounds were characterized by physical means. The ability of synthesized trimers to inhibit HIV-1 replication and to improve RNase L activation were investigated. Some of the synthesized trimers showed also biological inhibition of HIV-1 reverse transcriptase and HIV-1-induced syncytia formation. It was shown that AdoBn-containing trimers inhibited HIV-1-induced syncytia formation > 1500-fold, independently of the position of the AdoBn residue in the oligomer chain." @default.
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• W2006029648 date "1997-06-30" @default.
• W2006029648 modified "2023-10-14" @default.
• W2006029648 title "Nucleotides. Part LII. Synthesis and biological activity of new base-modified (2?-5?)oligoadenylate trimers" @default.
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• W2006029648 doi "https://doi.org/10.1002/hlca.19970800404" @default.
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