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- W2006035488 abstract "Current influenza virus vaccines primarily elicit antibodies and can be rendered ineffective by antigenic drift and shift. Vaccines that elicit CD8+ T cell responses targeting less variable proteins may function as universal vaccines that have broad reactivity against different influenza virus strains. To generate such a universal vaccine, we encapsulated live influenza virus in a biopolymer and delivered it to mice subcutaneously. This vaccine was safe, induced potent CD8+ T cell immunity and protected mice against heterosubtypic lethal challenge. Safety of subcutaneous (SQ) vaccination was tested in Rag-/-γc-/- double knockout mice which we show cannot control intranasal infection. Biopolymer encapsulation of live influenza virus could be used to develop universal CD8+ T cell vaccines against heterosubtypic and pandemic strains." @default.
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- W2006035488 date "2010-12-01" @default.
- W2006035488 modified "2023-09-24" @default.
- W2006035488 title "Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus" @default.
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- W2006035488 doi "https://doi.org/10.1016/j.vaccine.2010.10.036" @default.
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