FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006036905> ?p ?o ?g. }

• W2006036905 endingPage "361" @default.
• W2006036905 startingPage "361" @default.
• W2006036905 abstract "To provide evidence that genetic factors contribute to the development of thoracic aortic aneurysms (TAA) by demonstrating familial patterns of the disease.Retrospective review.University hospital.We sought to identify familial patterns of TAA from a database of 598 patients evaluated or treated for TAA at the Yale Center for Thoracic Aortic Disease, New Haven, Conn, from January 1985 to August 1998. Of the 598 patients, 45 patients had a diagnosis of Marfan syndrome and 553 patients had no known history of any collagen vascular disorder. Of the 553 patients in the latter category, 398 patients had confirmed TAA, 66 had TAA with concomitant aortic dissections, and 89 had aortic dissections. From the group of 464 patients with TAA with or without concomitant aortic dissections, 2 interviewers attempted to contact 150 randomly selected patients for telephone screening to determine the presence of familial patterns of aortic disease. Fifteen of these patients were lost to follow-up. Complete medical and family histories of the remaining 135 patients (85 men, 50 women) were reviewed. Of the 135 individuals screened, 26 (18 men, 8 women) (19.3%) were found to belong to multiplex pedigrees. These 26 patients with familial nonsyndromic TAA were compared with the remaining 109 patients with sporadic TAA and the 45 patients with Marfan syndrome-associated TAA.Groups were examined for statistical differences in age and aortic size at the time of diagnosis, growth rates of TAA, and rates of concomitant diseases. Nonsyndromic family pedigrees were analyzed and potential modes of inheritance were determined.The mean age at presentation for patients with familial nonsyndromic TAA (56.8 years) was significantly younger than the mean age of presentation in sporadic cases (64.3 years, P< or =.03), and significantly older than that of patients with Marfan syndrome (24.8 years, P< or =.001). Patients with a family history of aortic aneurysms had faster growth rates (0.22 cm/y) compared with patients with sporadic TAA (0.03 cm/y) (P< or =.001) and patients with Marfan syndrome (0.10 cm/y) (P< or =.04). Familial nonsyndromic TAA in patients with a concomitant aortic dissection had a growth rate of 0.33 cm/y, which was greater than that of patients with sporadic TAA (0.10 cm/y) and patients with Marfan syndrome (0.08 cm/y) with associated aortic dissection. This growth of 0.33 cm/y was significantly faster than the overall growth rate estimate of aneurysms in patients with aortic dissection (0.14 cm/y) (P< or =.05). Ten pedigrees (38.5%) showed direct father to son transmission, consistent with an autosomal dominant mode of inheritance. Six family pedigrees (23.1%) suggested an autosomal dominant or X-linked mode of inheritance. Seven pedigrees (26.9%) suggested a recessive mode of inheritance; 2 an autosomal recessive mode, and 5 an X-linked recessive or autosomal recessive mode. The remaining 3 pedigrees displayed more complex modes of inheritance.This study supports the role of genetic factors influencing familial aggregation of TAA. Thoracic aortic aneurysms in association with multiplex pedigrees represent a new risk factor for aneurysm growth. Pedigree analysis suggests genetic heterogeneity. The primary mode of inheritance seems to be autosomal dominant, but X-linked dominant and recessive modes are also evident." @default.
• W2006036905 created "2016-06-24" @default.
• W2006036905 creator A5004636668 @default.
• W2006036905 creator A5012261237 @default.
• W2006036905 creator A5012409470 @default.
• W2006036905 creator A5029299733 @default.
• W2006036905 creator A5046456290 @default.
• W2006036905 creator A5073596474 @default.
• W2006036905 creator A5074188782 @default.
• W2006036905 creator A5078032674 @default.
• W2006036905 creator A5090408695 @default.
• W2006036905 date "1999-04-01" @default.
• W2006036905 modified "2023-10-17" @default.
• W2006036905 title "Familial Patterns of Thoracic Aortic Aneurysms" @default.
• W2006036905 cites W1572983895 @default.
• W2006036905 cites W1588853979 @default.
• W2006036905 cites W1814736312 @default.
• W2006036905 cites W1986393016 @default.
• W2006036905 cites W2011196754 @default.
• W2006036905 cites W2018879447 @default.
• W2006036905 cites W2020360951 @default.
• W2006036905 cites W2028229586 @default.
• W2006036905 cites W2031825736 @default.
• W2006036905 cites W2046687862 @default.
• W2006036905 cites W2047637083 @default.
• W2006036905 cites W2049699620 @default.
• W2006036905 cites W2051715752 @default.
• W2006036905 cites W2052730870 @default.
• W2006036905 cites W2091473852 @default.
• W2006036905 cites W2098447041 @default.
• W2006036905 cites W2121961335 @default.
• W2006036905 cites W2144963994 @default.
• W2006036905 cites W2146979392 @default.
• W2006036905 cites W2319330567 @default.
• W2006036905 cites W2322417031 @default.
• W2006036905 cites W2326494110 @default.
• W2006036905 cites W2410052093 @default.
• W2006036905 cites W3115207579 @default.
• W2006036905 doi "https://doi.org/10.1001/archsurg.134.4.361" @default.
• W2006036905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10199307" @default.
• W2006036905 hasPublicationYear "1999" @default.
• W2006036905 type Work @default.
• W2006036905 sameAs 2006036905 @default.
• W2006036905 citedByCount "301" @default.
• W2006036905 countsByYear W20060369052012 @default.
• W2006036905 countsByYear W20060369052013 @default.
• W2006036905 countsByYear W20060369052014 @default.
• W2006036905 countsByYear W20060369052015 @default.
• W2006036905 countsByYear W20060369052016 @default.
• W2006036905 countsByYear W20060369052017 @default.
• W2006036905 countsByYear W20060369052018 @default.
• W2006036905 countsByYear W20060369052019 @default.
• W2006036905 countsByYear W20060369052020 @default.
• W2006036905 countsByYear W20060369052021 @default.
• W2006036905 countsByYear W20060369052022 @default.
• W2006036905 countsByYear W20060369052023 @default.
• W2006036905 crossrefType "journal-article" @default.
• W2006036905 hasAuthorship W2006036905A5004636668 @default.
• W2006036905 hasAuthorship W2006036905A5012261237 @default.
• W2006036905 hasAuthorship W2006036905A5012409470 @default.
• W2006036905 hasAuthorship W2006036905A5029299733 @default.
• W2006036905 hasAuthorship W2006036905A5046456290 @default.
• W2006036905 hasAuthorship W2006036905A5073596474 @default.
• W2006036905 hasAuthorship W2006036905A5074188782 @default.
• W2006036905 hasAuthorship W2006036905A5078032674 @default.
• W2006036905 hasAuthorship W2006036905A5090408695 @default.
• W2006036905 hasConcept C104317684 @default.
• W2006036905 hasConcept C126322002 @default.
• W2006036905 hasConcept C141071460 @default.
• W2006036905 hasConcept C164705383 @default.
• W2006036905 hasConcept C185592680 @default.
• W2006036905 hasConcept C187212893 @default.
• W2006036905 hasConcept C22593422 @default.
• W2006036905 hasConcept C2776098176 @default.
• W2006036905 hasConcept C2777323849 @default.
• W2006036905 hasConcept C2779134260 @default.
• W2006036905 hasConcept C2779384505 @default.
• W2006036905 hasConcept C2779980429 @default.
• W2006036905 hasConcept C2779993142 @default.
• W2006036905 hasConcept C2780561598 @default.
• W2006036905 hasConcept C2780847584 @default.
• W2006036905 hasConcept C2781179581 @default.
• W2006036905 hasConcept C55493867 @default.
• W2006036905 hasConcept C71924100 @default.
• W2006036905 hasConceptScore W2006036905C104317684 @default.
• W2006036905 hasConceptScore W2006036905C126322002 @default.
• W2006036905 hasConceptScore W2006036905C141071460 @default.
• W2006036905 hasConceptScore W2006036905C164705383 @default.
• W2006036905 hasConceptScore W2006036905C185592680 @default.
• W2006036905 hasConceptScore W2006036905C187212893 @default.
• W2006036905 hasConceptScore W2006036905C22593422 @default.
• W2006036905 hasConceptScore W2006036905C2776098176 @default.
• W2006036905 hasConceptScore W2006036905C2777323849 @default.
• W2006036905 hasConceptScore W2006036905C2779134260 @default.
• W2006036905 hasConceptScore W2006036905C2779384505 @default.
• W2006036905 hasConceptScore W2006036905C2779980429 @default.
• W2006036905 hasConceptScore W2006036905C2779993142 @default.
• W2006036905 hasConceptScore W2006036905C2780561598 @default.

• next