Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006039063> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2006039063 endingPage "1191" @default.
- W2006039063 startingPage "1183" @default.
- W2006039063 abstract "The aim of this study was to elucidate the efficacy of combination therapy with irinotecan and amrubicin for lung cancer and the influence of administration schedule in a xenograft mouse model and human cancer cell culture. We investigated the antitumor activity of irinotecan and amrubicin on human small cell lung cancer cell line LX-1 inoculated in mice in vivo and the cytotoxic effect of SN-38 and amrubicinol on human lung cancer cell lines A549 and PC-6 in vitro. Combined administration of irinotecan and amrubicin in divided doses inhibited tumor growth by approximately 90%, with complete recovery observed in one case. Furthermore, combined administration in divided doses induced little loss of body weight. Combination index analysis revealed that the cell growth inhibitory effect of SN-38 combined with amrubicinol was additive, regardless of schedule or cell line. The effect of combination treatment with SN-38 and amrubicinol on cell cycle was investigated. Cell cycle showed arrest at both the S and G2/M phases. The results indicate that combination therapy with irinotecan and amrubicin can be expected to yield improved outcomes, including less toxicity, especially with divided administration." @default.
- W2006039063 created "2016-06-24" @default.
- W2006039063 creator A5001674992 @default.
- W2006039063 creator A5062998033 @default.
- W2006039063 creator A5075684248 @default.
- W2006039063 creator A5085332509 @default.
- W2006039063 creator A5085973452 @default.
- W2006039063 date "2010-01-01" @default.
- W2006039063 modified "2023-09-27" @default.
- W2006039063 title "Efficacy of Combination Treatment and Influence of Schedule with Irinotecan and Amrubicin in Human Lung Carcinoma Cells in Vivo and in Vitro" @default.
- W2006039063 cites W1579431026 @default.
- W2006039063 cites W1794341310 @default.
- W2006039063 cites W1905197404 @default.
- W2006039063 cites W1969875009 @default.
- W2006039063 cites W1979045387 @default.
- W2006039063 cites W1990364135 @default.
- W2006039063 cites W2003830580 @default.
- W2006039063 cites W2009599943 @default.
- W2006039063 cites W2025897602 @default.
- W2006039063 cites W2034308419 @default.
- W2006039063 cites W2037830308 @default.
- W2006039063 cites W2037902796 @default.
- W2006039063 cites W2042588086 @default.
- W2006039063 cites W2047862032 @default.
- W2006039063 cites W2060818162 @default.
- W2006039063 cites W2065525784 @default.
- W2006039063 cites W2073683299 @default.
- W2006039063 cites W2077945404 @default.
- W2006039063 cites W2091430838 @default.
- W2006039063 cites W2108882850 @default.
- W2006039063 cites W2188738125 @default.
- W2006039063 doi "https://doi.org/10.1248/bpb.33.1183" @default.
- W2006039063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20606311" @default.
- W2006039063 hasPublicationYear "2010" @default.
- W2006039063 type Work @default.
- W2006039063 sameAs 2006039063 @default.
- W2006039063 citedByCount "1" @default.
- W2006039063 countsByYear W20060390632012 @default.
- W2006039063 crossrefType "journal-article" @default.
- W2006039063 hasAuthorship W2006039063A5001674992 @default.
- W2006039063 hasAuthorship W2006039063A5062998033 @default.
- W2006039063 hasAuthorship W2006039063A5075684248 @default.
- W2006039063 hasAuthorship W2006039063A5085332509 @default.
- W2006039063 hasAuthorship W2006039063A5085973452 @default.
- W2006039063 hasBestOaLocation W20060390631 @default.
- W2006039063 hasConcept C121608353 @default.
- W2006039063 hasConcept C126322002 @default.
- W2006039063 hasConcept C143998085 @default.
- W2006039063 hasConcept C150903083 @default.
- W2006039063 hasConcept C207001950 @default.
- W2006039063 hasConcept C2776256026 @default.
- W2006039063 hasConcept C2776999253 @default.
- W2006039063 hasConcept C2780259306 @default.
- W2006039063 hasConcept C526805850 @default.
- W2006039063 hasConcept C54355233 @default.
- W2006039063 hasConcept C71924100 @default.
- W2006039063 hasConcept C81885089 @default.
- W2006039063 hasConcept C86803240 @default.
- W2006039063 hasConcept C98274493 @default.
- W2006039063 hasConceptScore W2006039063C121608353 @default.
- W2006039063 hasConceptScore W2006039063C126322002 @default.
- W2006039063 hasConceptScore W2006039063C143998085 @default.
- W2006039063 hasConceptScore W2006039063C150903083 @default.
- W2006039063 hasConceptScore W2006039063C207001950 @default.
- W2006039063 hasConceptScore W2006039063C2776256026 @default.
- W2006039063 hasConceptScore W2006039063C2776999253 @default.
- W2006039063 hasConceptScore W2006039063C2780259306 @default.
- W2006039063 hasConceptScore W2006039063C526805850 @default.
- W2006039063 hasConceptScore W2006039063C54355233 @default.
- W2006039063 hasConceptScore W2006039063C71924100 @default.
- W2006039063 hasConceptScore W2006039063C81885089 @default.
- W2006039063 hasConceptScore W2006039063C86803240 @default.
- W2006039063 hasConceptScore W2006039063C98274493 @default.
- W2006039063 hasIssue "7" @default.
- W2006039063 hasLocation W20060390631 @default.
- W2006039063 hasLocation W20060390632 @default.
- W2006039063 hasOpenAccess W2006039063 @default.
- W2006039063 hasPrimaryLocation W20060390631 @default.
- W2006039063 hasRelatedWork W1990414540 @default.
- W2006039063 hasRelatedWork W2021857073 @default.
- W2006039063 hasRelatedWork W2052337464 @default.
- W2006039063 hasRelatedWork W2101599998 @default.
- W2006039063 hasRelatedWork W2160999601 @default.
- W2006039063 hasRelatedWork W2165225928 @default.
- W2006039063 hasRelatedWork W2899140013 @default.
- W2006039063 hasRelatedWork W3137670083 @default.
- W2006039063 hasRelatedWork W3198049980 @default.
- W2006039063 hasRelatedWork W4200071965 @default.
- W2006039063 hasVolume "33" @default.
- W2006039063 isParatext "false" @default.
- W2006039063 isRetracted "false" @default.
- W2006039063 magId "2006039063" @default.
- W2006039063 workType "article" @default.