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• W2006039401 abstract "The purpose of this research was to determine which species of laboratory animal provided the best approximation of in vitro percutaneous penetration and metabolism of T-2 in humans. The [3H]T-2 which penetrated discs of skin after 48 hr (expressed as per cent of dose, 581 ng/cm2) was 1.0, 1.4, 2.8 and 9.7% for the human, rabbit, guinea pig and rat when the vehicle was methanol. The penetration was 29.2, 19.6, 51.9 and 52.6% for the human, rabbit, guinea pig and rat when the vehicle was DMSO. When 2 concentrations were compared, 79 ng/cm2 and 581 ng/cm2 (the vehicle was methanol), the higher dose caused a significant (P<0.05) increase in the per cent of dose which penetrated human and guinea pig skin. Metabolism was extensive in the human, rabbit and rat, with the main metabolite being HT-2 toxin. Previous studies comparing human to monkey indicated penetration in these 2 species was different when methanol was the vehicle. This study indicates that the rabbit provides the best approximation of human skin, both in terms of penetration kinetics and metabolic activity." @default.
• W2006039401 created "2016-06-24" @default.
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• W2006039401 date "1987-01-01" @default.
• W2006039401 modified "2023-09-27" @default.
• W2006039401 title "In vitro percutaneous penetration and metabolism of [3H]T-2 toxin: Comparison of human, rabbit, guinea pig and rat" @default.
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• W2006039401 doi "https://doi.org/10.1016/0041-0101(87)90240-6" @default.
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