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- W2006039855 abstract "The stomach is a complex organ, carrying out diverse functions, such as the reception and grinding of ingested food; the secretion of acid, digestive enzymes, intrinsic factors, and mucus; and the transfer of the processed food into the intestine. These functions are integrated by a complex array of neural and peripheral control mechanisms that regulate gastric activity in concert with that of the entire digestive system, as well as other organs. To perform such complex activities, the mucosal lining of the stomach varies, and the mucosa is generally classified as cardiac, fundic, or antral, according to the anatomical location. The mucosal glands of these regions contain specialized cells that play key regulatory functions. For instance, gastrin, secreted from G cells in the antrum, regulates acid secretion and controls proliferation of the gastric mucosa, and the recently identified ghrelin, which is secreted from X-like cells in the fundic gland, seems to be involved in controlling appetite, as well as in gut motility. However, under normal conditions, the endoscopic differentiation of these specialized mucosal areas is difficult, even by an experienced hand. A number of exogenous and endogenous factors, such as infection (most notably with Helicobacter pylori); chemical injury, such as that caused by nonsteroidal anti-inflammatory drugs or bile acid; autoimmunity; and circulatory changes are known to affect the macroscopic appearance of the gastric mucosa. The clinical diagnosis of gastritis is based on endoscopically detectable mucosal changes, although the diagnostic sensitivity and accuracy depends on the observer. Therefore, the sensitivity and reproducibility are generally considered to be rather poor for differentiating subtle alterations such as these seen in gastritis [1]. In order to overcome this problem, an attempt to semiquantitatively score the mucosal appearance, to facilitate objective assessment, has been proposed, in line" @default.
- W2006039855 created "2016-06-24" @default.
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- W2006039855 date "2002-06-01" @default.
- W2006039855 modified "2023-09-22" @default.
- W2006039855 title "Grading of gastritis: an impossible dream?" @default.
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- W2006039855 doi "https://doi.org/10.1007/s101200200010" @default.
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