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- W2006040339 abstract "DNA methylation is a key regulator of gene expression and changes in DNA methylation occur early in tumorigenesis. Mutations in the de novo DNA methyltransferase gene, DNMT3A, frequently occur in adult acute myeloid leukemia patients with poor prognoses. Most of the mutations occur within the dimer or tetramer interface, including Arg-882. We have identified that the most prevalent mutation, R882H, and three additional mutants along the tetramer interface disrupt tetramerization. The processive methylation of multiple CpG sites is disrupted when tetramerization is eliminated. Our results provide a possible mechanism that accounts for how DNMT3A mutations may contribute to oncogenesis and its progression." @default.
- W2006040339 created "2016-06-24" @default.
- W2006040339 creator A5008499188 @default.
- W2006040339 creator A5062965079 @default.
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- W2006040339 date "2012-09-01" @default.
- W2006040339 modified "2023-10-14" @default.
- W2006040339 title "Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation" @default.
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- W2006040339 doi "https://doi.org/10.1074/jbc.m112.366625" @default.
- W2006040339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3438927" @default.
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