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- W2006044991 abstract "Significance DNA replication and histone gene transcription are tightly linked and occur during the S phase of the eukaryotic cell cycle. Histone production outside of S phase is highly toxic, underscoring the importance of regulatory pathways that control histone gene expression. Although various histone regulators have been discovered, the molecular mechanisms responsible for the spatial and temporal control of histone gene expression have remained elusive. Here, we describe the discovery of Spt21 as a long-elusive cell cycle oscillator responsible for restricting histone gene transcription to the S phase of the eukaryotic cell cycle. We show here that Spt21, together with its partner protein Spt10, regulates histone gene transcription by enabling the recruitment of a roster of chromatin-remodeling proteins." @default.
- W2006044991 created "2016-06-24" @default.
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- W2006044991 date "2014-09-16" @default.
- W2006044991 modified "2023-10-12" @default.
- W2006044991 title "Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation" @default.
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- W2006044991 doi "https://doi.org/10.1073/pnas.1414024111" @default.
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