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- W2006046129 abstract "Using immunodepletion of cyclin E and the inhibitor protein p21WAF/CIP1, we demonstrate that the cyclin E protein, in association with Cdk2, is required for the elongation phase of replication on single-stranded substrates. Although cyclin E/Cdk2 is likely to be the major target by which p21 inhibits the initiation of sperm DNA replication, p21 can inhibit single-stranded replication through a mechanism dependent on PCNA. While the cyclin E/Cdk2 complex appears to have a role in the initiation of DNA replication, another Cdk kinase, possibly cyclin A/Cdk, may be involved in a later step controlling the switch from initiation to elongation. The provision of a large maternal pool of cyclin E protein shows that regulators of replication are constitutively present, which explains the lack of a protein synthesis requirement for replication in the early embryonic cell cycle." @default.
- W2006046129 created "2016-06-24" @default.
- W2006046129 creator A5008558253 @default.
- W2006046129 creator A5015176214 @default.
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- W2006046129 creator A5080007807 @default.
- W2006046129 date "1995-08-15" @default.
- W2006046129 modified "2023-09-25" @default.
- W2006046129 title "Early events in DNA replication require cyclin E and are blocked by p21CIP1." @default.
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- W2006046129 doi "https://doi.org/10.1083/jcb.130.4.755" @default.
- W2006046129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199964" @default.
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