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- W2006050211 abstract "1. The effects of carbachol, monoamines and K+ upon the rate of inositol phospholipid breakdown in pig brain miniprisms have been investigated. 2. In the striatum, carbachol (EC50 approx. 1 μM) and noradrenaline (EC50, approx. 25 μM) stimulated inositol phospholipid breakdown, whereas 5-hydroxytryptamine (1–1000 μM) was without effect. 3. The rate of inositol phospholipid breakdown was increased by raising the assay [K+] to ⩾40mM. In the hippocampus and hypothalamus, a synergistic effect between K+ and carbachol was noted, whereas in the striatum, the effects were additive. 4. In striatal and hippocampal miniprisms, dopamine also increased inositol phospholipid breakdown, albeit only at high (⩾ 1 mM) concentrations. Dopamine (1 mM) reduced the stimulation produced by noradrenaline (1 mM), suggesting that the effect of dopamine is due to a weak noradrenergic action of this catecholamine." @default.
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- W2006050211 date "1989-01-01" @default.
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- W2006050211 title "Stimulation of inositol phospholipid breakdown in pig brain miniprisms by carbachol and monoamines: Effect of K+" @default.
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- W2006050211 doi "https://doi.org/10.1016/0020-711x(89)90104-3" @default.
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