FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006055431> ?p ?o ?g. }

• W2006055431 endingPage "6515" @default.
• W2006055431 startingPage "6507" @default.
• W2006055431 abstract "ABSTRACT Celiac disease (CD) is associated with intestinal dysbiosis, which can theoretically lead to dysfunctions in host-microbe interactions and contribute to the disease. In the present study, possible differences in Bacteroides spp. and their pathogenic features between CD patients and controls were investigated. Bacteroides clones ( n = 274) were isolated, identified, and screened for the presence of the virulence genes ( bft and mpII ) coding for metalloproteases. The proteolytic activity of selected Bacteroides fragilis strains was evaluated by zymography and, after gastrointestinal digestion of gliadin, by high-pressure liquid chromatography/electrospray ionization/tandem mass spectrometry. The effects of B. fragilis strains on Caco-2 cell culture permeability and inflammatory response to digested gliadin were determined. B. fragilis was more frequently identified in CD patients than in healthy controls, in contrast to Bacteroides ovatus . B. fragilis clones carrying virulence genes coding for metalloproteases were more abundant in CD patients than in controls. B. fragilis strains, representing the isolated clones and carrying metalloprotease genes, showed gelatinase activity and exerted the strongest adverse effects on the integrity of the Caco-2 cell monolayer. All B. fragilis strains also showed gliadin-hydrolyzing activity, and some of them generated immunogenic peptides that preserved or increased inflammatory cytokine production (tumor necrosis factor alpha) and showed increased ability to permeate through Caco-2 cell cultures. These findings suggest that increased abundance of B. fragilis strains with metalloprotease activities could play a role in CD pathogenesis, although further in vivo studies are required to support this hypothesis." @default.
• W2006055431 created "2016-06-24" @default.
• W2006055431 creator A5015912176 @default.
• W2006055431 creator A5046304271 @default.
• W2006055431 creator A5052122620 @default.
• W2006055431 date "2012-09-15" @default.
• W2006055431 modified "2023-10-14" @default.
• W2006055431 title "Discerning the Role of Bacteroides fragilis in Celiac Disease Pathogenesis" @default.
• W2006055431 cites W1948109564 @default.
• W2006055431 cites W1964238792 @default.
• W2006055431 cites W1972836029 @default.
• W2006055431 cites W1985022816 @default.
• W2006055431 cites W1986906886 @default.
• W2006055431 cites W1989394017 @default.
• W2006055431 cites W1992816747 @default.
• W2006055431 cites W2020460418 @default.
• W2006055431 cites W2026203167 @default.
• W2006055431 cites W2028504959 @default.
• W2006055431 cites W2037674018 @default.
• W2006055431 cites W2052584095 @default.
• W2006055431 cites W2054806896 @default.
• W2006055431 cites W2056040874 @default.
• W2006055431 cites W2061709265 @default.
• W2006055431 cites W2064318892 @default.
• W2006055431 cites W2069752121 @default.
• W2006055431 cites W2079851600 @default.
• W2006055431 cites W2081536852 @default.
• W2006055431 cites W2092578486 @default.
• W2006055431 cites W2096237446 @default.
• W2006055431 cites W2096369860 @default.
• W2006055431 cites W2097551408 @default.
• W2006055431 cites W2101175877 @default.
• W2006055431 cites W2108281900 @default.
• W2006055431 cites W2114755316 @default.
• W2006055431 cites W2116525393 @default.
• W2006055431 cites W2116629243 @default.
• W2006055431 cites W2120243636 @default.
• W2006055431 cites W2126446070 @default.
• W2006055431 cites W2128777474 @default.
• W2006055431 cites W2128985337 @default.
• W2006055431 cites W2129480002 @default.
• W2006055431 cites W2135375882 @default.
• W2006055431 cites W2137595704 @default.
• W2006055431 cites W2146100358 @default.
• W2006055431 cites W2150067149 @default.
• W2006055431 cites W2151987441 @default.
• W2006055431 cites W2155400081 @default.
• W2006055431 cites W2156024523 @default.
• W2006055431 cites W2160636110 @default.
• W2006055431 cites W2168033293 @default.
• W2006055431 cites W2168800337 @default.
• W2006055431 cites W2168802668 @default.
• W2006055431 cites W2327168319 @default.
• W2006055431 doi "https://doi.org/10.1128/aem.00563-12" @default.
• W2006055431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3426693" @default.
• W2006055431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22773639" @default.
• W2006055431 hasPublicationYear "2012" @default.
• W2006055431 type Work @default.
• W2006055431 sameAs 2006055431 @default.
• W2006055431 citedByCount "76" @default.
• W2006055431 countsByYear W20060554312012 @default.
• W2006055431 countsByYear W20060554312013 @default.
• W2006055431 countsByYear W20060554312014 @default.
• W2006055431 countsByYear W20060554312015 @default.
• W2006055431 countsByYear W20060554312016 @default.
• W2006055431 countsByYear W20060554312017 @default.
• W2006055431 countsByYear W20060554312018 @default.
• W2006055431 countsByYear W20060554312019 @default.
• W2006055431 countsByYear W20060554312020 @default.
• W2006055431 countsByYear W20060554312021 @default.
• W2006055431 countsByYear W20060554312022 @default.
• W2006055431 crossrefType "journal-article" @default.
• W2006055431 hasAuthorship W2006055431A5015912176 @default.
• W2006055431 hasAuthorship W2006055431A5046304271 @default.
• W2006055431 hasAuthorship W2006055431A5052122620 @default.
• W2006055431 hasBestOaLocation W20060554311 @default.
• W2006055431 hasConcept C104317684 @default.
• W2006055431 hasConcept C203014093 @default.
• W2006055431 hasConcept C2776357993 @default.
• W2006055431 hasConcept C2778168646 @default.
• W2006055431 hasConcept C2780246119 @default.
• W2006055431 hasConcept C2780942790 @default.
• W2006055431 hasConcept C501593827 @default.
• W2006055431 hasConcept C523546767 @default.
• W2006055431 hasConcept C54355233 @default.
• W2006055431 hasConcept C55493867 @default.
• W2006055431 hasConcept C60987743 @default.
• W2006055431 hasConcept C86803240 @default.
• W2006055431 hasConcept C89423630 @default.
• W2006055431 hasConceptScore W2006055431C104317684 @default.
• W2006055431 hasConceptScore W2006055431C203014093 @default.
• W2006055431 hasConceptScore W2006055431C2776357993 @default.
• W2006055431 hasConceptScore W2006055431C2778168646 @default.
• W2006055431 hasConceptScore W2006055431C2780246119 @default.
• W2006055431 hasConceptScore W2006055431C2780942790 @default.
• W2006055431 hasConceptScore W2006055431C501593827 @default.
• W2006055431 hasConceptScore W2006055431C523546767 @default.
• W2006055431 hasConceptScore W2006055431C54355233 @default.

• next